Results 31 to 40 of about 4,877,549 (387)

The TCGA Molecular Classification of Endometrial Cancer and Its Possible Impact on Adjuvant Treatment Decisions

Cancers, 2021
Simple Summary The Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) is a recently developed tool to identify four distinct molecular subgroups of endometrial cancer. Patients identified as Polymerase Epsilon exonuclease domain mutated
Matthias Alexa, A. Hasenburg, M. Battista   +2 more
semanticscholar   +1 more source

MicroRNA-135a promotes proliferation, migration, invasion and induces chemoresistance of endometrial cancer cells

European Journal of Obstetrics & Gynecology and Reproductive Biology: X, 2020
Aims: MicroRNAs play essential roles in tumorigenesis and progression in various cancers including endometrial cancer. Here we assessed the role of miR-135a on proliferation, chemosensitivity, migration and invasion of endometrial cancer cells.
Jiping Wang, Li Zhang, Wenyan Jiang, Rongkui Zhang, Bei Zhang, Aidaeraili Silayiding, Xiumei Duan   +6 more
doaj   +1 more source

LncRNA SNHG4 Modulates EMT Signal and Antitumor Effects in Endometrial Cancer through Transcription Factor SP-1

Biomedicines, 2023
Long non-coding RNAs (lncRNAs) are implicated in the initiation and progression of a variety of tumors, including endometrial cancer. However, the mechanisms of lncRNA in endometrial cancer formation and progression remain largely unknown. In this study,
Lee Kyung Kim, Sun-Ae Park, Eun Ji Nam, Young Tae Kim, Tae-Hwe Heo, Hee Jung Kim   +5 more
doaj   +1 more source

PDIA6, which is regulated by TRPM2-AS/miR-424-5p axis, promotes endometrial cancer progression via TGF-beta pathway

Cell Death and Disease, 2023
PDIA6 have been reported to be involved in a variety of cancers, however, the underlying role in endometrial cancer is still unclear. In this study, we aimed to study the function of PDIA6 in endometrial cancer.
Pengling Wang, Tianli Zhang, Nan Jiang, Kun Wang, Liping Feng, Ting Liu, Xingsheng Yang   +6 more
doaj   +1 more source

Progestins Related to Progesterone and Testosterone Elicit Divergent Human Endometrial Transcriptomes and Biofunctions. [PDF]

, 2020
Progestins are widely used for the treatment of gynecologic disorders and alone, or combined with an estrogen, are used as contraceptives. While their potencies, efficacies and side effects vary due to differences in structures, doses and routes of ...
Balayan, Shayna, Chen, Joseph C, Giudice, Linda C, Greenblatt, Ruth M, Houshdaran, Sahar, Irwin, Juan C, Smith-McCune, Karen, Vallvé-Juanico, Júlia, Vo, Kim Chi   +8 more
core   +2 more sources

Metapristone (RU486-derivative) inhibits endometrial cancer cell progress through regulating miR-492/Klf5/Nrf1 axis

Cancer Cell International, 2021
Background Endometrial cancer is an invasive gynecological cancer prevalent in the world. The pathogenesis of endometrial cancer is related to multiple levels of regulation, referring to oestrogen, tumor-suppressor gene (e.g. PTEN) or microRNAs (e.g. miR-
Yue Chang, Min Hao, Ru Jia, Yihui Zhao, Yixuan Cai, Yun Liu   +5 more
doaj   +1 more source

Molecular Basis of Endometriosis and Endometrial Cancer: Current Knowledge and Future Perspectives

International Journal of Molecular Sciences, 2021
The human endometrium is a unique tissue undergoing important changes through the menstrual cycle. Under the exposure of different risk factors in a woman’s lifetime, normal endometrial tissue can give rise to multiple pathologic conditions, including ...
M. Terzic, G. Aimagambetova, J. Kunz, G. Bapayeva, B. Aitbayeva, S. Terzic, A. Laganà   +6 more
semanticscholar   +1 more source

ALDH1 expression predicts progression of premalignant lesions to cancer in Type I endometrial carcinomas

Scientific Reports, 2021
In type 1 endometrial cancer, unopposed estrogen stimulation is thought to lead to endometrial hyperplasia which precedes malignant progression. Recent data from our group and others suggest that ALDH activity mediates stemness in endometrial cancer, but
Vei Mah, Yahya Elshimali, Alison Chu, Neda A. Moatamed, Jamar P. Uzzell, Jessica Tsui, Stephen Schettler, Hania Shakeri, Madhuri Wadehra   +8 more
doaj   +1 more source

Association between diabetes, diabetes treatment and risk of developing endometrial cancer. [PDF]

, 2014
BackgroundA growing body of evidence suggests that diabetes is a risk factor for endometrial cancer incidence. However, most of these studies used case-control study designs and did not adjust for obesity, an established risk factor for endometrial ...
Beresford, S, Chen, C, Chlebowski, R, Garcia, L, Kuller, L, Luo, J, Margolis, KL, Regier, M, Wactawski-Wende, J   +8 more
core   +2 more sources

Molecular Classification of the PORTEC-3 Trial for High-Risk Endometrial Cancer: Impact on Prognosis and Benefit From Adjuvant Therapy

Journal of Clinical Oncology, 2020
PURPOSE The randomized Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in Women With High-Risk Endometrial Cancer (PORTEC-3) trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy (CTRT) versus radiotherapy alone (RT) for ...
A. Léon-Castillo, S. D. de Boer, M. Powell, L. Mileshkin, H. Mackay, A. Leary, H. Nijman, N. Singh, P. Pollock, P. Bessette, A. Fyles, C. Haie-meder, V. Smit, R. Edmondson, H. Putter, H. Kitchener, E. Crosbie, M. de Bruyn, R. Nout, N. Horeweg, C. Creutzberg, T. Bosse   +21 more
semanticscholar   +1 more source