Extracellular vesicles secreted by equine adipose mesenchymal stem cells preconditioned with transforming growth factor β-1 are enriched in anti-fibrotic miRNAs and inhibit the expression of fibrotic genes in an in vitro system of endometrial stromal cells fibrosis [PDF]
Veterinary QuarterlyMare endometrosis is a major reproductive problem associated with low fertility and is characterized by persistent inflammation, TGFβ-1 signaling, and consequently, extracellular matrix deposition, which compromises endometrial glands.
Yat Sen Wong +8 more
doaj +2 more sources
Milk fat globule EGF and factor V/VIII domain containing (MFGE8) as a novel player in equine endometrial fibrosis [PDF]
Scientific ReportsWith increasing age, mares are frequently affected by endometrial fibrosis. Transforming growth factor beta 1 (TGF-β1) promotes fibrosis, while milk fat globule EGF and factor V/VIII domain containing (MFGE8) primarily exerts antifibrotic effects.
Elena zu Klampen +2 more
doaj +2 more sources
Different expression of Defensin-B gene in the endometrium of mares of different age during the breeding season [PDF]
BMC Veterinary Research, 2019 Background Despite being one of the major causes of infertility in mares, the mechanisms responsible for equine endometrosis are still unclear and controversial.
M. Crociati +6 more
doaj +2 more sources
Expression of oestrogen and progesterone receptor and intermediate filament proteins in the oviduct of mares with endometrosis [PDF]
Animal Science and Genetics, 2023 Equine endometrosis is one of the major causes of equine infertility, often associated with signs of periglandular fibrosis occurring in the endometrium.
Magdalena Profaska +5 more
doaj +1 more source
General and comparative aspects of endometritis in domestic species: A review
Reproduction in Domestic Animals, Volume 58, Issue S2, Page 49-71, September 2023., 2023 Abstract Endometritis is a leading cause of sub‐ and infertility in domestic animal species. The healthy uterus is colonized by commensal bacteria, viruses and yeast/fungi that represent the nonpathogenic microbiota. A shift in the number or type of organisms accompanied by immune dysfunction, however, may trigger uterine infection and inflammation ...
O. Bogado Pascottini +3 more
wiley +1 more source
Identification and Analysis of Potential Immune‐Related Biomarkers in Endometriosis
Journal of Immunology Research, Volume 2023, Issue 1, 2023., 2023 Background. Endometriosis is an inflammatory gynecological disease leading to deep pelvic pain, dyspareunia, and infertility. The pathophysiology of endometriosis is complex and depends on a variety of biological processes and pathways. Therefore, there is an urgent need to identify reliable biomarkers for early detection and accurate diagnosis to ...
Yanan He +7 more
wiley +1 more source
British Journal of Pharmacology, Volume 178, Issue 20, Page 4104-4118, October 2021., 2021 Background and Purpose Limited evidence suggests that the sphingosine‐1‐phosphate/sphingosine kinase 1 (S1P/SPHK1) signalling pathway is involved in the pathogenesis of endometriosis. Therefore, we analyzed in this study whether the inhibition of SPHK1 and, consequently, decreased levels of S1P affected the vascularization and growth of endometriotic ...
Jeannette Rudzitis‐Auth +3 more
wiley +1 more source
Noscapine Acts as a Protease Inhibitor of In Vitro Elastase-Induced Collagen Deposition in Equine Endometrium. [PDF]
Int J Mol Sci, 2021 Endometrosis is a reproductive pathology that is responsible for mare infertility. Our recent studies have focused on the involvement of neutrophil extracellular traps enzymes, such as elastase (ELA), in the development of equine endometrosis. Noscapine (
Amaral A +5 more
europepmc +2 more sources
Endometrosis – significance for horse reproduction, pathogenesis, diagnosis, and proposed therapeutic methods [PDF]
, 2014 Equine endometrosis is a multifactorial disease considered to be a one of the most important causes of equine infertility, especially in older mares. This article reviews the current knowledge of equine endometrosis: pathogenesis, diagnosis, and optional
Buczkowska, J. +9 more
core +2 more sources
Endometriosis as very common cause of chronic pelvic pain – overview of actual knowledge
Journal of Education, Health and Sport, 2023 Introduction and purpose of the study: Endometriosis is a prevalent condition that affects women in their reproductive years. Diagnosing the condition and determining its manifestations can be complex and uncertain, as they vary among individuals.
Karolina Miszczyk +9 more
doaj +1 more source