The effect of lysophosphatidic acid on myometrial contractility and the mRNA transcription of its receptors in the myometrium at different stages of endometrosis in mares [PDF]
BMC Veterinary ResearchBackground Endometrosis (chronic degenerative endometritis) results in morphological changes in the equine endometrium and impairs its secretory function. However, the effect of this condition on the myometrium remains unclear. Lysophosphatidic acid (LPA)
Katarzyna Karolina Piotrowska-Tomala +7 more
doaj +3 more sources
Th1 and Th2 cells in equine endometrosis and their interactions with endometrial fibroblasts [PDF]
Scientific ReportsMare endometrosis is a chronic degenerative condition of the endometrium, primarily characterized by fibrosis, involving interactions among fibroblasts, immune cells, and epithelial cells regulated by cytokines and growth factors.
Anna Wójtowicz +7 more
doaj +3 more sources
The Inhibition of Cathepsin G on Endometrial Explants With Endometrosis in the Mare [PDF]
Frontiers in Veterinary Science, 2020 Although proteases found in neutrophil extracellular traps (NETs) have antimicrobial properties, they also stimulate collagen type 1 (COL1) production by the mare endometrium, contributing for the development of endometrosis.
Ana Amaral +10 more
doaj +3 more sources
The Healthy and Diseased Equine Endometrium: A Review of Morphological Features and Molecular Analyses [PDF]
Animals, 2020 Mares are seasonally polyestric. The breeding season in spring and summer and the winter anestrus are flanked by transitional periods. Endometrial diseases are a frequent cause of subfertility and have an economic impact on the horse breeding industry ...
Sandra Schöniger, Heinz-Adolf Schoon
doaj +3 more sources
Matrix metallopeptidase expression and modulation by transforming growth factor-β1 in equine endometrosis [PDF]
Scientific Reports, 2020 application/pdfEquine endometrial fibrosis (endometrosis) is described as a degenerative chronic condition in the uterus. Its characteristic feature is excessive deposition of extracellular matrix (ECM) components around the endometrial glands and stroma.
Dariusz Jan Skarzynski +2 more
exaly +6 more sources
Molecular Mechanism of Equine Endometrosis: The NF-κB-Dependent Pathway Underlies the Ovarian Steroid Receptors’ Dysfunction [PDF]
International Journal of Molecular Sciences, 2022 Endometrosis is a frequently occurring disease decreasing mares’ fertility. Thus, it is an important disease of the endometrium associated with epithelial and stromal cell alterations, endometrium gland degeneration and periglandular fibrosis.
Edyta Juszczuk-Kubiak +2 more
exaly +3 more sources
The Inhibitory Effect of Noscapine on the In Vitro Cathepsin G-Induced Collagen Expression in Equine Endometrium [PDF]
Life, 2021 Cathepsin G (CAT) is a protease released by neutrophils when forming neutrophil extracellular traps that was already associated with inducing type I collagen (COL1) in equine endometrium in vitro. Endometrosis is a fibrotic condition mainly characterized
Ana Amaral +7 more
doaj +2 more sources
Exploring the role of epigenetics in the processes related to the development of endometrosis in the mare [PDF]
The Journal of Reproduction and DevelopmentEndometrosis is a chronic degenerative condition of the mare endometrium characterized by progressive fibrosis and glandular alterations that impair uterine function and fertility.
Katarzyna PIOTROWSKA-TOMALA +7 more
doaj +2 more sources
5-Aza-2′-Deoxycytidine (5-Aza-dC, Decitabine) Inhibits Collagen Type I and III Expression in TGF-β1-Treated Equine Endometrial Fibroblasts [PDF]
Animals, 2023 Endometrosis negatively affects endometrial function and fertility in mares, due to excessive deposition of type I (COL1) and type III (COL3) collagens.
Joana Alpoim-Moreira +5 more
doaj +2 more sources
Enzymes Present in Neutrophil Extracellular Traps May Stimulate the Fibrogenic PGF2α Pathway in the Mare Endometrium [PDF]
Animals, 2021 Endometrosis, a fibrotic disease of mare endometrium, impairs uterine function. Prostaglandins (PG), despite modulating reproductive physiological functions, may also cause local pathological collagen deposition (fibrogenesis).
Maria Rosa Rebordão +9 more
doaj +2 more sources