Equine Endometrosis Pathological Features: Are They Dependent on NF-κB Signaling Pathway? [PDF]
Animals, 2021 Endometrosis is an important mares’ disease which considerably decreases their fertility. As classic endometrial classification methods might be insufficient for tissue pathological evaluation, further categorization into active/inactive and destructive ...
Edyta Juszczuk-Kubiak +2 more
exaly +4 more sources
Evolution of the Concepts of Endometrosis, Post Breeding Endometritis, and Susceptibility of Mares [PDF]
Animals, 2022 In this paper, the evolution of our understanding about post breeding endometritis (PBE), the susceptibility of mares, and events leading to endometrosis are reviewed.
Graça Maria Leitão Ferreira Dias +1 more
exaly +4 more sources
Prostaglandin pathways in equine myometrium regulations: endometrosis progression [PDF]
Frontiers in Veterinary ScienceIntroductionProstaglandins (PG) are important regulators of the myometrial contractility in mammals. Endometrosis, a condition characterized by morphological changes in the equine endometrium, also affects endometrial secretory function.
Katarzyna Piotrkowska-Tomala +2 more
exaly +4 more sources
The myometrial transcriptome changes in mares with endometrosis [PDF]
Scientific ReportsMares with endometrosis exhibit histological changes not only in the endometrium but also in the myometrium that suggest possible functional impairment. The molecular background of these changes is not well understood.
Katarzyna Piotrkowska-Tomala +2 more
exaly +3 more sources
Transcriptomic profiling of mare endometrium at different stages of endometrosis [PDF]
Scientific Reports, 2023 In the current study, transcriptome profiles of mare endometrium, classified into categories I, IIA, and IIB according to Kenney and Doig, were compared using RNA sequencing, analyzed, and functionally annotated using in silico analysis.
A. Szóstek-Mioduchowska +10 more
doaj +2 more sources
The potential role of miRNAs and regulation of their expression in the development of mare endometrial fibrosis [PDF]
Scientific Reports, 2023 Mare endometrial fibrosis (endometrosis), is one of the main causes of equine infertility. Despite the high prevalence, both ethology, pathogenesis and the nature of its progression remain poorly understood.
Anna Wójtowicz +10 more
doaj +2 more sources
Collagen Type III as a Possible Blood Biomarker of Fibrosis in Equine Endometrium [PDF]
Animals, 2022 Collagen pathological deposition in equine endometrium (endometrosis) is responsible for infertility. Kenney and Doig’s endometrial biopsy histopathological classification is the gold standard method for endometrosis evaluation, whereby blood biomarkers ...
Joana Alpoim-Moreira +8 more
doaj +2 more sources
The NF-κB-signalling pathway in mare's endometrium infiltrated with the inflammatory cells. [PDF]
Reprod Domest Anim, 2022 Abstract Endometritis is an important issue decreasing mares' fertility. In the case of endometritis, both inflammatory cells infiltration and proinflammatory molecules production are regulated by various cellular and gene regulatory mechanisms, including the nuclear factor‐κB (NF‐κB)‐dependent pathway.
Jasiński T +5 more
europepmc +2 more sources
Metallopeptidades 2 and 9 genes epigenetically modulate equine endometrial fibrosis [PDF]
Frontiers in Veterinary Science, 2022 Endometrium type I (COL1) and III (COL3) collagen accumulation, periglandular fibrosis and mare infertility characterize endometrosis. Metalloproteinase-2 (MMP-2), MMP-9 and tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) are involved in ...
Joana Alpoim-Moreira +15 more
doaj +2 more sources
Lysophosphatidic acid as a regulator of endometrial connective tissue growth factor and prostaglandin secretion during estrous cycle and endometrosis in the mare [PDF]
BMC Veterinary Research, 2020 Background Equine endometrosis is a chronic degenerative condition, described as endometrial fibrosis that forms in the stroma, under the basement membrane and around the endometrial glands.
Anna Szóstek-Mioduchowska +5 more
doaj +2 more sources