Results 1 to 10 of about 3,976 (116)

Structural and evolutionary insights into astacin metallopeptidases

Frontiers in Molecular Biosciences, 2023
The astacins are a family of metallopeptidases (MPs) that has been extensively described from animals. They are multidomain extracellular proteins, which have a conserved core architecture encompassing a signal peptide for secretion, a prodomain or ...
Walter Stöcker, F Xavier Gomis-Rüth
exaly   +3 more sources

Low-intensity pulsed ultrasound affects proliferation and migration of human hepatocellular carcinoma cells [PDF]

Journal of Cancer Research and Clinical Oncology
Purpose Low-intensity pulsed ultrasound (LIPUS) is an effective ancillary treatment modality for various malignancies. However, the mechanisms underlying the role of LIPUS in cancer treatment have not been fully elucidated.
Mingzhen Yang, Zhihui Lu, Bangzhong Liu, Guanghua Liu, Mingfang Shi, Ping Wang   +5 more
doaj   +2 more sources

Molecular basis of Fab-dependent IgA antibody recognition by gut-bacterial metallopeptidases [PDF]

The EMBO Journal
Immunoglobulin A (IgA) is essential for mucosal immunity and has been implicated in autoimmune diseases, such as IgA nephropathy. Certain pathogenic and commensal bacteria produce IgA proteases that selectively cleave IgA, potentially aiding bacterial ...
María Ángeles Márquez-Moñino, Ana Martínez Gascueña, Tala Azzam, Andrea Persson, Aitor Manzanares-Gomez, Marina Aguillo-Urarte, Trenton T Brown, Ainhoa Montero-Sagarminaga, Rolf Lood, Andreas Naegeli, Sean R Connell, Diego E Sastre, Eric J Sundberg, Beatriz Trastoy   +13 more
doaj   +2 more sources

Peptidases Are Potential Targets of Copper(II)-1,10-Phenanthroline-5,6-dione Complex, a Promising and Potent New Drug against Trichomonas vaginalis

Pathogens, 2023
Trichomonas vaginalis is responsible for 156 million new cases per year worldwide. When present asymptomatically, the parasite can lead to serious complications, such as development of cervical and prostate cancer.
Graziela Vargas Rigo, Fernanda Gomes Cardoso, Matheus Mendonça Pereira, Michael Devereux, Malachy McCann, André L. S. Santos, Tiana Tasca   +6 more
doaj   +1 more source

Myeloperoxidase Inhibition Decreases the Expression of Collagen and Metallopeptidase in Mare Endometria under In Vitro Conditions

Animals, 2021
Neutrophils can originate neutrophil extracellular traps (NETs). Myeloperoxidase (MPO) is a peroxidase found in NETs associated to equine endometrosis and can be inhibited by 4-aminobenzoic acid hydrazide (ABAH).
Ana Amaral, Carina Fernandes, Maria Rosa Rebordão, Anna Szóstek-Mioduchowska, Karolina Lukasik, Pedro Pinto-Bravo, Luís Telo da Gama, Dariusz Jan Skarzynski, Graça Ferreira-Dias   +8 more
doaj   +1 more source

Involvement of Matrix Metalloproteinases in COVID-19: Molecular Targets, Mechanisms, and Insights for Therapeutic Interventions

Biology, 2023
MMPs are enzymes involved in SARS-CoV-2 pathogenesis. Notably, the proteolytic activation of MMPs can occur through angiotensin II, immune cells, cytokines, and pro-oxidant agents.
Rebecca Salomão, Victoria Assis, Ivo Vieira de Sousa Neto, Bernardo Petriz, Nicolas Babault, João Luiz Quaglioti Durigan, Rita de Cássia Marqueti   +6 more
doaj   +1 more source

Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases

IUCrJ, 2020
Tannerella forsythia is an oral dysbiotic periodontopathogen involved in severe human periodontal disease. As part of its virulence factor armamentarium, at the site of colonization it secretes mirolysin, a metallopeptidase of the unicellular pappalysin ...
Tibisay Guevara, Arturo Rodriguez-Banqueri, Miroslaw Ksiazek, Jan Potempa, F. Xavier Gomis-Rüth   +4 more
doaj   +1 more source

The In Vitro Inhibitory Effect of Sivelestat on Elastase Induced Collagen and Metallopeptidase Expression in Equine Endometrium

Animals, 2020
Neutrophil extracellular traps (NETs) fight endometritis, and elastase (ELA), a protease found in NETs, might induce collagen type I (COL1) accumulation in equine endometrium. Metallopeptidases (MMPs) are involved in extracellular matrix balance. The aim
Ana Amaral, Carina Fernandes, Maria Rosa Rebordão, Anna Szóstek-Mioduchowska, Karolina Lukasik, Barbara Gawronska-Kozak, Luís Telo da Gama, Dariusz J. Skarzynski, Graça Ferreira-Dias   +8 more
doaj   +1 more source

The Inhibition of Cathepsin G on Endometrial Explants With Endometrosis in the Mare

Frontiers in Veterinary Science, 2020
Although proteases found in neutrophil extracellular traps (NETs) have antimicrobial properties, they also stimulate collagen type 1 (COL1) production by the mare endometrium, contributing for the development of endometrosis.
Ana Amaral, Carina Fernandes, Sofia Morazzo, Maria Rosa Rebordão, Maria Rosa Rebordão, Anna Szóstek-Mioduchowska, Karolina Lukasik, Barbara Gawronska-Kozak, Luís Telo da Gama, Dariusz Jan Skarzynski, Graça Ferreira-Dias   +10 more
doaj   +1 more source

Association of Sonic Hedgehog with the extracellular matrix requires its zinc-coordination center

BMC Molecular and Cell Biology, 2021
Background Sonic Hedgehog (Shh) has a catalytic cleft characteristic for zinc metallopeptidases and has significant sequence similarities with some bacterial peptidoglycan metallopeptidases defining a subgroup within the M15A family that, besides having ...
Carina Jägers, Henk Roelink
doaj   +1 more source