Results 21 to 30 of about 4,715 (225)

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Thermolysin and related Bacillus metallopeptidases

, 2004
Bertu van den Burg, Vincent Eijsink
core   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Matrix metallopeptidases regulate granulosa cell remodeling through the hormone signaling pathway

Journal of Advanced Veterinary and Animal Research, 2020
Objective: Granulosa cells (GCs) play a very important role in reproductive physiology due to their effect on developmental and functional changes. However, there are differing views regard¬ing the mechanism by which hormones stimulate GCs.
Sang Hwan Kim, Jong Taek Yoon
doaj   +1 more source

Enhancement of Activity and Thermostability of Keratinase From Pseudomonas aeruginosa CCTCC AB2013184 by Directed Evolution With Noncanonical Amino Acids

Frontiers in Bioengineering and Biotechnology, 2021
A keratinase from Pseudomonas aeruginosa (KerPA), which belongs to the M4 family of metallopeptidases, was characterised in this study. This enzyme was engineered with non-canonical amino acids (ncAAs) using genetic code expansion.
Xianchao Pan, Jian Yang, Peijuan Xie, Jing Zhang, Famin Ke, Xiurong Guo, Manyu Liang, Li Liu, Qin Wang, Xiaowei Gao, Xiaowei Gao, Xiaowei Gao   +11 more
doaj   +1 more source

Association of the MMP-3, MMP-9 and MMP-12 gene polymorphisms with COPD risk: a meta-analysis

Archives of Medical Science, 2021
Introduction Given the evidence that the matrix metalloproteinases (MMPs) play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD), a number of case-control studies have attempted to assess the relationship between ...
Hua Zhao, Xiao-Hong Jiang, Qiu-Pin Huang, Min-Li Chen, Zheng-Fu Xie   +4 more
doaj   +1 more source

Verticillium longisporum Elicits Media-Dependent Secretome Responses With Capacity to Distinguish Between Plant-Related Environments

Frontiers in Microbiology, 2020
Verticillia cause a vascular wilt disease affecting a broad range of economically valuable crops. The fungus enters its host plants through the roots and colonizes the vascular system.
Miriam Leonard, Anika Kühn, Rebekka Harting, Isabel Maurus, Alexandra Nagel, Jessica Starke, Harald Kusch, Oliver Valerius, Kirstin Feussner, Ivo Feussner, Alexander Kaever, Manuel Landesfeind, Burkhard Morgenstern, Dörte Becher, Michael Hecker, Susanna A. Braus-Stromeyer, James W. Kronstad, Gerhard H. Braus   +17 more
doaj   +1 more source

Purification and characterisation of a metallopeptidase of Candida albicans [PDF]

Journal of Medical Microbiology, 1995
A novel aminopeptidase was purified by high performance liquid chromatography from a cytosoluble 100,000 g extract of Candida albicans on the basis of its ability to cleave L-arginine 7-amino-4-methylcoumarin. The purification factor was 36 and the yield was 20%. The native enzyme had a mol.
B, el Moudni, M H, Rodier, C, Barrault, M, Ghazali, J L, Jacquemin   +4 more
openaire   +2 more sources

Crystal structure of outer membrane protein NMB0315 from Neisseria meningitidis. [PDF]

PLoS ONE, 2011
NMB0315 is an outer membrane protein of Neisseria meningitidis serogroup B (NMB) and a potential candidate for a broad-spectrum vaccine against meningococcal disease.
Xiangyu Wang, Xue Yang, Chunting Yang, Zhenhua Wu, Honglin Xu, Yuequan Shen   +5 more
doaj   +1 more source

Computational Insights into Mechanisms and Structures of Metallopeptidases and Amyloid Beta Peptide Aggregation

, 2012
In the present thesis, the structural and mechanistic information of natural and artificial metallopeptidases and aggregation mechanisms of amyloid beta (Aβ) peptide associated with Alzheimer’s disease (AD) have been explored using innovative ...
Zhu, Xiaoxia
core   +3 more sources