Results 11 to 20 of about 4,715 (225)
Metallopeptidases of Toxoplasma gondii: in silico identification and gene expression
Parasite, 2018 Metallopeptidases are a family of proteins with domains that remain highly conserved throughout evolution. These hydrolases require divalent metal cation(s) to activate the water molecule in order to carry out their catalytic action on peptide bonds by ...
Escotte-Binet Sandie +6 more
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Functional and structural insights into astacin metallopeptidases [PDF]
bchm, 2013 The astacins are a family of multi-domain metallopeptidases with manifold functions in metabolism. They are either secreted or membrane-anchored and are regulated by being synthesized as inactive zymogens and also by colocalizing protein inhibitors.
Trillo-Muyo, Sergio +2 more
core +5 more sources
Characterization of Ca2+ interactions with matrix metallopeptidase-12: implications for matrix metallopeptidase regulation [PDF]
Biochemical Journal, 2006 Matrix metallopeptidase-12 (MMP-12) binds three calcium ions and a zinc ion, in addition to the catalytic zinc ion. These ions are thought to have a structural role, stabilizing the active conformation of the enzyme. To characterize the importance of Ca2+ binding for MMP-12 activity and the properties of the different Ca2+ sites, the activity as a ...
Thomas, Gossas, U Helena, Danielson
openaire +2 more sources
e causes cellular trans-differentiation in human bronchial epithelia
Innate Immunity, 2021 Non-typeable Haemophilus influenzae (NTHi) is the most common respiratory pathogen in patients with chronic obstructive disease. Limited data is available investigating the impact of NTHi infections on cellular re-differentiation processes in the ...
Michael Glöckner +8 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 LGMDD2 is a rare form of muscular dystrophy characterized by one of the three heterozygous deletions described within the TNPO3 gene that result in the addition of a 15-amino acid tail in the C-terminus.TNPO3 is involved in the nuclear import of splicing
Francisco Diez-Fuertes +24 more
doaj +1 more source
The crude skin secretion of the pepper frog Leptodactylus labyrinthicus is rich in metallo and serine peptidases. [PDF]
PLoS ONE, 2014 Peptidases are ubiquitous enzymes involved in diverse biological processes. Fragments from bioactive peptides have been found in skin secretions from frogs, and their presence suggests processing by peptidases.
Michelle da Silva Libério +5 more
doaj +1 more source
Peptidoglycan Amidase MepA Is a LAS Metallopeptidase [PDF]
Journal of Biological Chemistry, 2004 LAS enzymes are a group of metallopeptidases that share an active site architecture and a core folding motif and have been named according to the group members lysostaphin, D-Ala-D-Ala carboxypeptidase and sonic hedgehog. Escherichia coli MepA is a periplasmic, penicillin-insensitive murein endopeptidase that cleaves the D-alanyl-meso-2,6-diamino ...
Malgorzata, Marcyjaniak +3 more
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Characterization of endopeptidases from the midgut of Morimus funereus (Coleoptera: Cerambycidae) larvae [PDF]
Archives of Biological Sciences, 2008 Application of specific chromogenic substrates, use of class-specific inhibitors, and zymogram analysis enabled us to identify several peptidase classes in extracts of the midgut of Morimus funereus larvae.
Božić Nataša +5 more
doaj +1 more source