Myeloperoxidase Inhibition Decreases the Expression of Collagen and Metallopeptidase in Mare Endometria under In Vitro Conditions [PDF]
Animals, 2021 Neutrophils can originate neutrophil extracellular traps (NETs). Myeloperoxidase (MPO) is a peroxidase found in NETs associated to equine endometrosis and can be inhibited by 4-aminobenzoic acid hydrazide (ABAH).
Ana Amaral +8 more
doaj +2 more sources
The In Vitro Inhibitory Effect of Sivelestat on Elastase Induced Collagen and Metallopeptidase Expression in Equine Endometrium [PDF]
Animals, 2020 Neutrophil extracellular traps (NETs) fight endometritis, and elastase (ELA), a protease found in NETs, might induce collagen type I (COL1) accumulation in equine endometrium. Metallopeptidases (MMPs) are involved in extracellular matrix balance. The aim
Ana Amaral +8 more
doaj +2 more sources
Bidirectional Interaction Between PGE2-Preconditioned Mesenchymal Stem Cells and Myofibroblasts Mediates Anti-Fibrotic Effects: A Proteomic Investigation into Equine Endometrial Fibrosis Reversal [PDF]
ProteomesBackground: Endometrosis is a prevalent fibrotic condition in mares that impairs reproductive efficiency by inducing transdifferentiation of endometrial stromal cells into myofibroblasts, leading to excessive ECM deposition.
Lidice Méndez-Pérez +5 more
doaj +2 more sources
Assessment of Connective Tissue in the Equine Uterus and Cervix: Review of Clinical Impact and Staining Options [PDF]
AnimalsUterine diseases stand as the primary cause of infertility in mares; however, the diagnostic process often relies on obtaining endometrial biopsies and their hematoxylin–eosin staining.
Łukasz Zdrojkowski +4 more
doaj +2 more sources
Mare stromal endometrial cells differentially modulate inflammation depending on oestrus cycle status: an in vitro study [PDF]
Frontiers in Veterinary Science, 2023 The modulation of inflammation is pivotal for uterine homeostasis. Here we evaluated the effect of the oestrus cycle on the expression of pro-inflammatory and anti-inflammatory markers in a cellular model of induced fibrosis.
Yat S. Wong +8 more
doaj +2 more sources
Changes in expression pattern of selected endometrial proteins following mesenchymal stem cells infusion in mares with endometrosis. [PDF]
PLoS ONE, 2014 Mesenchymal stem cells (MSCs) due to their self-renewal potential and differentiation capacity are useful for tissue regeneration. Immunomodulatory and trophic properties of MSCs were demonstrated suggesting their use as medicinal signaling cells able to
Lisley I Mambelli +8 more
doaj +2 more sources
Endometritis and endometrial fibrosis are associated with alterations in mare endometrial proteome [PDF]
BMC Veterinary ResearchEquine persistent post-breeding endometritis may lead to endometrosis, characterized by excessive fibrosis, which is a major cause of subfertility/infertility.
Mariana Leal +10 more
doaj +2 more sources
Simple Tube Centrifugation Method for Platelet-Rich Plasma (PRP) Preparation in Catalonian Donkeys as a Treatment of Endometritis-Endometrosis [PDF]
Animals, 2021 The aim of this study was to standardize a simple, manual platelet-rich plasma (PRP) protocol in Catalonian donkeys using single-spin tube centrifugation as a treatment for jenny endometritis.
Priscila Fantini +7 more
doaj +2 more sources
Ovarian steroids modulate mRNA expression of ECM associated genes and collagen deposition induced by TGF β1 in equine endometrium in vitro [PDF]
Scientific ReportsEquine endometrosis is a major cause of infertility in mares and is characterized by degenerative, functional and fibrotic changes in the endometrium with increased collagen (COL) deposition.
Ana Amaral +6 more
doaj +2 more sources
Advances in the Diagnosis of Reproductive Disorders in Female Camelids [PDF]
AnimalsCamelids are increasingly recognized as important livestock species. They are valuable sources of meat, fiber, and milk. Despite their growing popularity, many aspects of their reproductive physiology and pathology remain unclear.
Abdelmalek Sghiri +4 more
doaj +2 more sources