Results 101 to 110 of about 155,310 (382)
Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases
Nucleic Acids Research, 2013 In many bacteria and archaea, small RNAs derived from clustered regularly interspaced short palindromic repeats (CRISPRs) associate with CRISPR-associated (Cas) proteins to target foreign DNA for destruction.
O. Niewoehner, M. Jinek, J. Doudna
semanticscholar +1 more source
Highly Secure In Vivo DNA Data Storage Driven by Genomic Dynamics
Advanced Science, EarlyView.Integrated computational‐biological programming enables secure in vivo data storage by generating code tables from either genomes or gene regulatory networks, expanding the encryption key space by over 100 orders of magnitude. Storing code tables within synthetic genes, genomes, or gene regulatory networks adds an additional layer of security by ...
Jiaxin Xu +9 more
wiley +1 more source
Unnatural Amino Acid and Emerging Chemistry Approaches to Map RNA–Protein Interactions
Angewandte Chemie, EarlyView.This review highlights emerging chemistries for mapping RNA–protein interactions, including genetically encoded unnatural amino acids, novel photocrosslinkers, and non‐photoactivatable crosslinking systems. We compare their mechanisms, reactivity and applications, outlining how these next‐generation tools enable higher‐resolution, site‐specific ...
Eryn Lundrigan +3 more
wiley +2 more sources
The cap-snatching SFTSV endonuclease domain is an antiviral target [PDF]
, 2020 Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%-30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States.
Amarasinghe, Gaya K +11 more
core +1 more source
MultiBac: expanding the research toolbox for multiprotein complexes [PDF]
, 2012 This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Berger, Imre +3 more
core +1 more source
Editorial: NAR Surveys the Past, Present and Future of Restriction Endonucleases
Nucleic Acids Research, 2013 In this issue, Nucleic Acids Research presents five Survey and Summary articles that describe the historical development of studies on restriction endonucleases and summarize much of our current understanding of this diverse and complex group of enzymes.
W. Dynan, K. Fox, B. Stoddard
semanticscholar +1 more source
Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA
Advanced Science, EarlyView.We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang +12 more
wiley +1 more source
Droplet Digital CRISPR for Nucleic Acid Detection
Advanced Science, EarlyView.This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang +4 more
wiley +1 more source
Artificial and Natural Genetic Information Processing [PDF]
, 2017 Conventional methods of genetic engineering and more recent genome editing techniques focus on identifying genetic target sequences for manipulation.
Witzany, Guenther
core
Advanced Science, EarlyView.This study identifies POLD4 as a potential prostate cancer radiosensitization target through transcriptome sequencing. By encapsulating POLD4‐targeted CRISPR/Cas9 plasmids and USPIONs in cationic liposomes, an MRI‐monitored gene‐editing platform is established.
Xuhui Fan +10 more
wiley +1 more source