Results 181 to 190 of about 55,351 (242)

Droplet Digital CRISPR for Nucleic Acid Detection

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review outlines recent advances in droplet digital CRISPR technology for nucleic acid detection, combining CRISPR specificity with droplet digital‐based absolute quantification. It summarizes core principles, amplification‐assisted and amplification‐free strategies, and representative DNA and RNA biomarker applications.
Yang Zhang, Roy S. K. Walker, Anwar Sunna, Tracie J. Barber, Ming Li   +4 more
wiley   +1 more source

Complete genome sequences of Cluster FE <i>Arthrobacter globiformis</i> phages Piku and Utopia. [PDF]

MicroPubl Biol
Labib S, Hafeez A, Choudry H, Ali R, Hussain K, Olascoaga E, Khan M, Kamal Y, Fatima S, Slakeski N, Syeda M, Muhammad I, Khan B, Pérez Morales T.   +13 more
europepmc   +1 more source

CRISPR‐Cas9‐Loaded Theranostic Liposomes for Enhancing Radiosensitization of Prostate Cancer through POLD4 Gene Editing under Real‐Time MRI Monitoring

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study identifies POLD4 as a potential prostate cancer radiosensitization target through transcriptome sequencing. By encapsulating POLD4‐targeted CRISPR/Cas9 plasmids and USPIONs in cationic liposomes, an MRI‐monitored gene‐editing platform is established.
Xuhui Fan, Ruru Zhang, Linjun Yang, Shixiong Chen, Meijuan He, Yongqiang Wang, Linjie Huang, Jianfeng Zeng, Shuwang Wu, Mingyuan Gao, Han Wang   +10 more
wiley   +1 more source

Editorial: Insights in genome editing in human health and disease 2023/2024. [PDF]

Front Genome Ed
Lu B, Mou H, Liang C.
europepmc   +1 more source

Evolution of Prime Editing: Enhancing Efficiency and Expanding Capacity

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Most rare diseases are caused by genetic mutations. Prime editing (PE) has emerged as a versatile tool capable of inducing diverse mutations without generating DNA double‐strand breaks. Despite its significant clinical potential, PE faces limitations in terms of efficiency and scalability.
Jihyeon Yu, Ju‐Chan Park, Heesoo Uhm, Yong‐Woo Kim, Hyeon Woo Im, Sangsu Bae   +5 more
wiley   +1 more source

Molecular effects of transposable element sequences in mammalian cells. [PDF]

Genome Biol
Wen MC, Welch JD.
europepmc   +1 more source

Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...
Yuanli Gao, Cheng Huang, Jiaxuan Deng, Lei Wang, Baojun Wang   +4 more
wiley   +1 more source

A pentose, as a cytosine nucleobase modification in <i>Shewanella</i> phage Thanatos genomic DNA, mediates enhanced resistance toward host restriction systems. [PDF]

Appl Environ Microbiol
Brandt D, Dörrich AK, Persicke M, Kemmler A, Leonhard T, Haak M, Nölting S, Ruwe M, Schmid N, Thormann KM, Kalinowski J.   +10 more
europepmc   +1 more source

Inhibition of Autophagy Reveals ATR Protein Kinase as a Key Mediator of Cisplatin Sensitivity in Osteosarcoma

Cancer Medicine, Volume 15, Issue 3, March 2026.
ATRi blocks phosphorylation of p53 (S15) and enhances cell death in cisplatin‐treated osteosarcoma cells. ABSTRACT Introduction Osteosarcoma (OS) is the most common primary malignant bone tumor. Although the introduction of chemotherapy has improved the survival rate of OS patients, chemoresistance remains a major clinical problem underlying poor ...
Janice S. Pereira, Gabriel Rosa, Aine Pears, Beata Burczynska, Britta Stordal, Scott J. Roberts, Helen C. Roberts   +6 more
wiley   +1 more source

<i>Shallot virus X</i> p42 Protein Expressed in Concert with Virus Movement Proteins Is a Suppressor of Two Plant Antiviral Defense Mechanisms. [PDF]

Plants (Basel)
Chergintsev DA, Lezzhov AA, Lazareva EA, Atabekova AK, Solovieva AD, Morozov SY, Solovyev AG.   +6 more
europepmc   +1 more source