Biochemical characterization and X-ray structural and mutagenic analyses of the putative autolysin CdCwlT33800 catalytic domain from Clostridioides difficile [PDF]
Applied and Environmental MicrobiologyClostridioides difficile is a major pathogen of pseudomembranous colitis, and new antimicrobial agents are needed for its treatment. Autolysins are peptidoglycan-degrading enzymes that generally reorganize the cell wall during cell division but kill ...
Hiroshi Sekiya +3 more
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Safety evaluation of the food enzyme papain, a cysteine endopeptidase complex from the latex of Carica papaya L. [PDF]
EFSA JournalThe food enzyme is a cysteine endopeptidase complex, containing papain (EC 3.4.22.2), chymopapain (EC 3.4.22.6), caricain (EC 3.4.22.30) and glycyl endopeptidase (EC 3.4.22.25), obtained from the latex of unripe Carica papaya L.
EFSA Panel on Food Enzymes (FEZ) +15 more
doaj +4 more sources
Contribution of UbrA, a ubiquitin ligase essential for Arg/N-degron pathway, to peptidase gene expression in Aspergillus oryzae [PDF]
Applied and Environmental MicrobiologyThe degradation of intracellular proteins by N-degron pathways depends on their N-terminal amino acids. In budding yeast, the Arg/N-degron pathway controls the expression of dipeptide/tripeptide transporter gene by degrading a transcriptional repressor ...
Waka Muromachi +4 more
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Safety evaluation of the food enzyme serine endopeptidase from the genetically modified Aspergillus niger strain NZYM‐MG [PDF]
EFSA JournalThe food enzyme serine endopeptidase (EC 3.4.21) is produced with the genetically modified Aspergillus niger strain NZYM‐MG by Novozymes A/S. The genetic modifications do not give rise to safety concerns.
EFSA Panel on Food Enzymes (FEZ) +14 more
doaj +2 more sources
Comparative Transcriptome Analysis Reveals Expression of Defense Pathways and Specific Protease Inhibitor Genes in Solanum lycopersicum in Response to Feeding by Tuta absoluta [PDF]
InsectsUnderstanding plant-insect interactions can help control the harm of herbivorous pests. According to transcriptome data, transcripts of Solanum lycopersicum responding to feeding by Tuta absoluta were screened for important endopeptidase inhibitors ...
Yan Zhou +4 more
doaj +2 more sources
Toxins, 2021 The safe and effective dosing of botulinum neurotoxins (BoNTs) requires accurate and reliable methods to measure their potency. Several novel methods have been introduced over the past decade; however, only few studies have compared the potency of BoNT ...
Ji-Yeon Hong +4 more
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mBio, 2021 During evolution, enzymes can undergo shifts in preferred substrates or in catalytic activities. An intriguing question is how enzyme function changes following horizontal gene transfer, especially for bacterial genes that have moved to animal genomes ...
Thomas E. Smith +5 more
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Animal Models and Experimental Medicine, 2023 β‐Amyloid (Aβ) is a specific pathological hallmark of Alzheimer's disease (AD). Because of its neurotoxicity, AD patients exhibit multiple brain dysfunctions.
Haolin Zhang +5 more
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Molecules, 2021 The Angiotensin-I-converting enzyme (ACE) is a peptidase with a significant role in the regulation of blood pressure. Within this work, a systematic review on the enzymatic preparation of Angiotensin-I-Converting Enzyme inhibitory (ACEi) peptides is ...
Azis Boing Sitanggang +5 more
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Functional Analysis of the Endopeptidase and Holin From Planktothrix agardhii Cyanophage PaV-LD
Frontiers in Microbiology, 2022 A cyanophage PaV-LD, previously isolated from harmful filamentous cyanobacterium Planktothrix agardhii, was sequenced, and co-expression of its two ORFs in tandem, ORF123 and ORF124, inhibited growth on the model cyanobacterium Synechocystis sp.
Li-Hui Meng +5 more
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