Results 11 to 20 of about 82,787 (343)
Animal Models and Experimental Medicine, 2023 β‐Amyloid (Aβ) is a specific pathological hallmark of Alzheimer's disease (AD). Because of its neurotoxicity, AD patients exhibit multiple brain dysfunctions.
Haolin Zhang +5 more
doaj +1 more source
Molecules, 2021 The Angiotensin-I-converting enzyme (ACE) is a peptidase with a significant role in the regulation of blood pressure. Within this work, a systematic review on the enzymatic preparation of Angiotensin-I-Converting Enzyme inhibitory (ACEi) peptides is ...
Azis Boing Sitanggang +5 more
doaj +1 more source
Frontiers in Nutrition, 2023 This study investigated the hydrolysis effect of the endopeptidase from wheat malt on the soybean meal proteins. The results indicated that the endopeptidase broke the peptide bonds of soybean meal proteins and converted the alcohol- and alkali-soluble ...
Jingxiao Fan +3 more
doaj +1 more source
mBio, 2021 During evolution, enzymes can undergo shifts in preferred substrates or in catalytic activities. An intriguing question is how enzyme function changes following horizontal gene transfer, especially for bacterial genes that have moved to animal genomes ...
Thomas E. Smith +5 more
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Evaluation of Enkephalin-Degrading Enzymes in Sperm from Heroin-Addicted Men [PDF]
International Journal of Fertility and Sterility, 2020 Background The aim of this study was to investigate two enkephalin-degrading enzymes, aminopeptidase N (APN/ CD13) and endopeptidase (NEP/CD10), gene and protein expression levels in sperm samples of fertile and heroin- addicted men, and the ...
Samira Rezaei-Mojaz +9 more
doaj +1 more source
Toxins, 2021 The safe and effective dosing of botulinum neurotoxins (BoNTs) requires accurate and reliable methods to measure their potency. Several novel methods have been introduced over the past decade; however, only few studies have compared the potency of BoNT ...
Ji-Yeon Hong +4 more
doaj +1 more source
IgG Endopeptidase in Highly Sensitized Patients Undergoing Transplantation
New England Journal of Medicine, 2017 n engl j med 377;17 nejm.org October 26, 2017 1692 Radecki and DeLoughery are concerned about the divergence in the median times to the cessation of bleeding that were reported in the interim and final analyses of the data from the RE-VERSE AD study. For
S. Jordan +25 more
semanticscholar +2 more sources
Journal of Biological Chemistry, 1995 A peptidase, isolated from rat testes, is inhibited by 1 mM o-phenanthroline, 1 microM N-(1-(R,S)-carboxyl-3-phenylpropyl)-Ala-Ala-Phe-p-aminobenzoate, and 6 mM Pro-Ile, properties similar to those ascribed to endopeptidase 24.16. The enzyme hydrolyzes dynorphin A-8, neurotensin 1-13, angiotensin I, and substance P.
Louis B. Hersh, Donald Rodd
openaire +3 more sources
Gut microbial DL-endopeptidase alleviates Crohn's disease via the NOD2 pathway [PDF]
, 2022 The pattern-recognition receptor NOD2 senses bacterial muropeptides to regulate host immunity and maintain homeostasis. Loss-of-function mutations in NOD2 are associated with Crohn's disease (CD), but how the variations in microbial factors influence ...
Fu, Jingyuan +12 more
core +2 more sources
Nature Communications, 2020 Asparaginyl endopeptidases (AEPs) catalyze the key backbone cyclization step during the biosynthesis of plant-derived cyclic peptides. Here, we report the identification of two AEPs from Momordica cochinchinensis and biochemically characterize MCoAEP2 ...
Junqiao Du +9 more
semanticscholar +1 more source