Comparative analysis of thermal adaptations of extremophilic prolyl oligopeptidases. [PDF]
Biophys JProlyl oligopeptidases from psychrophilic, mesophilic, and thermophilic organisms found in a range of natural environments are studied using a combination of protein structure prediction, atomistic molecular dynamics, and trajectory analysis to determine
Diessner EM +3 more
europepmc +6 more sources
Structural analysis of prolyl oligopeptidases using molecular docking and dynamics: insights into conformational changes and ligand binding. [PDF]
PLoS ONE, 2011 Prolyl oligopeptidase (POP) is considered as an important pharmaceutical target for the treatment of numerous diseases. Despite enormous studies on various aspects of POPs structure and function still some of the questions are intriguing like ...
Swati Kaushik, Ramanathan Sowdhamini
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Computational analysis of human gut microbial prolyl oligopeptidases (POPs) reveal candidate genes as therapeutics for celiac disease [PDF]
Scientific ReportsCeliac disease (CD) is a common autoimmune disorder in which the patients are unable to digest gluten, which is present in foods made up of wheat, barley and rye.
Soumya Nayak +2 more
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Cross genome comparisons of serine proteases in Arabidopsis and rice [PDF]
BMC Genomics, 2006 Background Serine proteases are one of the largest groups of proteolytic enzymes found across all kingdoms of life and are associated with several essential physiological pathways.
Sowdhamini R, Tripathi Lokesh P
doaj +5 more sources
The MSDIN family in amanitin-producing mushrooms and evolution of the prolyl oligopeptidase genes [PDF]
IMA Fungus, 2018 The biosynthetic pathway for amanitins and related cyclic peptides in deadly Amanita (Amanitaceae) mushrooms represents the first known ribosomal cyclic peptide pathway in the Fungi.
Hong Luo +6 more
doaj +3 more sources
Oleuropein as a Potent Compound against Neurological Complications Linked with COVID-19: A Computational Biology Approach [PDF]
Entropy, 2022 The association of COVID-19 with neurological complications is a well-known fact, and researchers are endeavoring to investigate the mechanistic perspectives behind it.
Talib Hussain +10 more
doaj +2 more sources
Distribution, classification, domain architectures and evolution of prolyl oligopeptidases in prokaryotic lineages. [PDF]
BMC Genomics, 2014 BACKGROUND: Prolyl oligopeptidases (POPs) are proteolytic enzymes, widely distributed in all the kingdoms of life. Bacterial POPs are pharmaceutically important enzymes, yet their functional and evolutionary details are not fully explored.
Kaushik S, Sowdhamini R.
europepmc +2 more sources
Dithymoquinone Analogues as Potential Candidate(s) for Neurological Manifestation Associated with COVID-19: A Therapeutic Strategy for Neuro-COVID [PDF]
Life, 2022 The COVID-19 era has prompted several researchers to search for a linkage between COVID-19 and its associated neurological manifestation. Toll-like receptor 4 (TLR-4) acts as one such connecting link.
Afrasim Moin +9 more
doaj +2 more sources
Gapped alignment of protein sequence motifs through Monte Carlo optimization of a hidden Markov model [PDF]
BMC Bioinformatics, 2004 Background Certain protein families are highly conserved across distantly related organisms and belong to large and functionally diverse superfamilies.
Liu Jun S, Neuwald Andrew F
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Prolyl oligopeptidase is inhibited in relapsing-remitting multiple sclerosis [PDF]
Journal of Neuroinflammation, 2010 Peer ...
Jofre Tenorio-Laranga +4 more
core +6 more sources