Results 41 to 50 of about 717 (174)
Sustainable Food Proteins, Volume 3, Issue 4, December 2025.The aims of this work were to obtain bioactive peptides from brewer's spent yeast (BSY) proteins and to evaluate its antihypertensive and neuroprotective properties before and after the simulated gastrointestinal digestion and in vitro colonic fermentation process. All samples showed antihypertensive and neuroprotective properties.
Marilin E. Aquino +3 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets
British Journal of Pharmacology, Volume 182, Issue S1, Page S1-S23, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +51 more
wiley +1 more source
Purification and Characterisation of Endopeptidase Produced by Lactococcus Lactis Subsp. Lactis RI 11 [PDF]
, 2001 In the this study, 10 isolates of Lactic Acid Bacteria (LAB) were isolated from ikan rebus (steam fish) purchased from a local market, was characterised by phenotypical and biochemical characteristics.
Woo, Kwan Kit
core
The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
Journal of Neurochemistry, Volume 169, Issue 12, December 2025.The Ndel1 protein is crucial for neurodevelopment, but its role in the brain peptidome is unknown. Here we compared the peptidome of Ndel1 conditional knockout (Ndel1_cKO) mice with controls (CTRL) in four brain regions. Peptides were extracted using acidic (Acetic Acid, AcOH) and organic (Methanol, MeOH) methods and analyzed by Liquid Chromatography ...
João V. Nani +9 more
wiley +1 more source
THE USE OF DIFFERENT PROTEASES TO HYDROLYZE GLIADINS [PDF]
, 2015 Gliadins represent alcohol-soluble fraction of wheat storage proteins which is responsible for development of celiac disease. The only and effective treatment for celiac disease is strict adherence to a gluten-free diet excluding any food made with wheat,
Barbara Mickowska +3 more
core +2 more sources
Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of Sulfonylfluoride Peptidomimetics [PDF]
Cell Chemical Biology, 2018 Prolyl oligopeptidase (POP), a serine protease highly expressed in the brain, has recently emerged as an enticing therapeutic target for the treatment of cognitive and neurodegenerative disorders. However, most reported inhibitors suffer from short duration of action, poor protease selectivity, and low blood-brain barrier (BBB) permeability, which ...
Guardiola Bagán, Salvador +8 more
openaire +5 more sources
Tetrazole as a Replacement of the Electrophilic Group in Characteristic Prolyl Oligopeptidase Inhibitors [PDF]
, 2019 4-Phenylbutanoyl-aminoacyl-2(S)-tetrazolylpyrrolidines were studied as prolyl oligopeptidase inhibitors. The compounds were more potent than expected from the assumption that the tetrazole would also here be a bioisostere of the carboxylic acid group and
Eteläinen, Tony S. +5 more
core +1 more source
Protein Science, Volume 34, Issue 11, November 2025.Abstract Acylpeptide hydrolase (APEH) or acylaminoacyl‐peptidase (AAP) is a serine hydrolase that regulates protein metabolism. It can also bind to and process unusual substrates, acting as a detoxifier. To better understand its promiscuous specificity, we determined the cryo‐EM structures of mammalian APEH complexed with classical serine protease ...
Anna J. Kiss‐Szemán +8 more
wiley +1 more source
Properties of the prolyl oligopeptidase homologue from Pyrococcus furiosus [PDF]
FEBS Letters, 2006 Prolyl oligopeptidase (POP), the paradigm of a serine peptidase family, hydrolyses peptides, but not proteins. The thermophilic POP from Pyrococcus furiosus (Pfu) appeared to be an exception, since it hydrolysed large proteins. Here we demonstrate that the Pfu POP does not display appreciable activity against azocasein.
Juhász, Tünde +2 more
openaire +2 more sources