Ibrain, Volume 10, Issue 4, Page 427-438, Winter 2024.Pathological Tau is one of the primary pathological features of AD. Tau aggregation is more closely associated with synaptic loss, neurodegeneration, and cognitive decline than Aβ in Alzheimer's disease (AD). Tau can undergo various posttranslational modifications (PTMs), including phosphorylation, acetylation, SUMOylation, succinylation ...
Xin Li +6 more
wiley +1 more source
Programmed cell death: molecular mechanisms, biological functions, diseases, and therapeutic targets
MedComm, Volume 5, Issue 12, December 2024.Programmed cell death is a type of autonomic and orderly cell death mode controlled by genes. We reviewed molecular mechanisms of five programmed cell death, including apoptosis, autophagy, pyroptosis, necroptosis, and ferroptosis. Programmed cell death is widely involved in the normal physiological process of the organism.
Shen'er Qian +7 more
wiley +1 more source
Structural visualization of inhibitor binding in prolyl oligopeptidase
Biophysics ReviewsThe association and dissociation of proteins and ligands are crucial in biophysics for potential drug development [Baron and McCammon, Annu. Rev. Phys. Chem. 64, 151–175 (2013)]. However, identifying and characterizing the reaction pathways for these rare events has been a long-standing challenge.
Katarzyna Walczewska-Szewc +1 more
openaire +2 more sources
Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cells. [PDF]
, 2018 Made available in DSpace on 2018-06-05T00:40:50Z (GMT). No. of bitstreams: 1 ID277921.pdf: 1343722 bytes, checksum: d514a3b1ca241360a0cb8b5492056aa0 (MD5) Previous issue date: 2007-01 ...
AUGUSTYNS, K. +10 more
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Thimet oligopeptidase (EC 3.4.24.15) key functions suggested by knockout mice phenotype characterization [PDF]
, 2019 Thimet oligopeptidase (THOP1) is thought to be involved in neuropeptide metabolism, antigen presentation, neurodegeneration, and cancer. Herein, the generation of THOP1 C57BL/6 knockout mice (THOP1(-/-)) is described showing that they are viable, have ...
Abilio, V.C. +26 more
core +1 more source
Effect of pre-treatment on the generation of dipeptidyl peptidase-IV- and prolyl endopeptidase-inhibitory hydrolysates from bovine lung [PDF]
, 2017 peer-reviewedThe aim of this work was to study the effect of two different pre-treatments, high temperature (100 °C, 5 min) and high pressure (600 MPa, 3 min), on the potential of the enzymes papain, collagenase and Alcalase® to generate bioactive ...
Hayes, Maria, Lafarga, Tomas
core +2 more sources
Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis.
Cell, 1998 Prolyl oligopeptidase is a large cytosolic enzyme that belongs to a new class of serine peptidases. The enzyme is involved in the maturation and degradation of peptide hormones and neuropeptides, which relate to the induction of amnesia. The 1.4 A resolution crystal structure is presented here.
Fülöp, Vilmos +2 more
openaire +2 more sources
A serine oligopeptidase from African Trypanosomes. [PDF]
, 1998 Thesis (Ph.D.)-University of Natal, Pietermaritzburg, 1998.Protozoan parasites of the genus Trypanosoma are responsible for chronic and widespread disease in livestock and humans in Africa.
Morty, Rory Edward.
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Catalysis of serine oligopeptidases is controlled by a gating filter mechanism [PDF]
Proteases have a variety of strategies for selecting substrates in order to prevent uncontrolled protein degradation. A recent crystal structure determination of prolyl oligopeptidase has suggested a way for substrate selection involving an unclosed ...
Vilmos Fülöp +4 more
core +1 more source