Results 51 to 60 of about 717 (174)
The Plant Genome, Volume 18, Issue 3, September 2025.Abstract Stem rot, caused by Sclerotium rolfsii Sacc., is a devastating soil‐borne disease causing up to 80% yield losses in groundnut globally. To dissect the genetic basis of resistance, we evaluated a diverse minicore germplasm panel over 3 years in stem rot sick‐field conditions.
H. V. Veerendrakumar +11 more
wiley +1 more source
Twenty years of therapeutic development in tauopathy mouse models: a scoping review
Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.Abstract Tauopathies are neurodegenerative diseases characterized by pathological tau protein inclusions and dementia. Tauopathy mouse models with MAPT mutations replicate tau‐related pathologies and are widely used for therapeutic research. This scoping review examines 409 treatment evaluations in MAPT mouse models.
Vanessa F. Langness +8 more
wiley +1 more source
Designing Enzymatic Reactivity with an Expanded Palette
ChemBioChem, Volume 26, Issue 11, June 3, 2025.Innovation in biocatalysis is rapidly increasingly the diversity of catalytic reactivity that can be mediated by enzymes, addressing a key bottleneck for their widespread adoption in industrial chemical synthesis. A key approach to this is building enzymes with unnatural catalytic components that provide an expanded palette with new possibilities for ...
Reuben B. Leveson‐Gower
wiley +1 more source
The purification and characterisation of a Z-pro-prolinal insensitive Z-gly-pro-MCA degrading peptidase from bovine serum [PDF]
, 2000 The study of a novel prolme-specific peptidase from bovine serum is presented. The enzyme readily cleaves Z-Gly-Pro-MCA liberating the fluorophore MCA thus allowing quantification of enzyme activity Unlike prolyl ohgopeptidase (PO) which also hydrolyses ...
Birney, Yvonne A.
core
Inhibition of prolyl oligopeptidase with a synthetic unnatural dipeptide [PDF]
Bioorganic & Medicinal Chemistry, 2010 A new inhibitor, containing a linked proline-piperidine structure, for the enzyme prolyl oligopeptidase (POP) has been synthesised and demonstrated to bind covalently with the enzyme at the active site. This provides evidence that covalent inhibitors of POP do not have to be limited to structures containing five-membered N-containing heterocyclic rings.
Racys, Daugirdas Tomas +3 more
openaire +2 more sources
ChemBioChem, Volume 26, Issue 10, May 27, 2025.Leishmaniasis poses a global health challenge with limited treatment options and rising drug resistance. Activity‐based protein profiling using fluorophosphonate probes is employed to profile serine hydrolases, key virulence factors in Leishmania mexicana.
Jaime A. Isern +7 more
wiley +1 more source
Dipeptidyl Peptidase 4 (DPP4) Exacerbates Osteoarthritis Progression in an Enzyme‐Independent Manner
Advanced Science, Volume 12, Issue 6, February 10, 2025.In normal conditions, the E3 ubiquitin ligase Carboxyl terminus of Hsc70‐interacting protein (CHIP) binds to and promotes the ubiquitination of Myosin heavy chain 9 (MYH9). The balance between mitochondrial fusion and fission is maintained. In osteoarthritis, Dipeptidyl peptidase 4 (DPP4) competitively binds to MYH9, preventing its ubiquitination. MYH9
Xinyu Li +5 more
wiley +1 more source
The study of a new and specific proline cleaving peptidase from bovine serum [PDF]
, 2003 Prolyl oligopeptidase is a serine peptidase characterised by oligoendopeptidase activity. Definitive evidence for the discrete biological role of prolyl oligopeptidase remains unknown, though its role in the maturation and degradation of peptide hormones
Collins, Patrick
core
Ang II (Angiotensin II) Conversion to Angiotensin-(1-7) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent [PDF]
, 2020 The Ang II (Angiotensin II)-Angiotensin-(1-7) axis of the Renin Angiotensin System encompasses 3 enzymes that form Angiotensin-(1-7) [Ang-(1-7)] directly from Ang II: ACE2 (angiotensin-converting enzyme 2), PRCP (prolylcarboxypeptidase), and POP ...
Bader, Michael +10 more
core +1 more source
Acta Physiologica, Volume 241, Issue 2, February 2025.Abstract The Renin‐Angiotensin System (RAS) is a complex neuroendocrine system consisting of a single precursor protein, angiotensinogen (AGT), which is processed into various peptide hormones, including the angiotensins [Ang I, Ang II, Ang III, Ang IV, Ang‐(1–9), Ang‐(1–7), Ang‐(1–5), etc] and Alamandine‐related peptides [Ang A, Alamandine, Ala‐(1–5)],
Igor Maciel Souza‐Silva +3 more
wiley +1 more source