The genome of Strongyloides spp. gives insights into protein families with a putative role in nematode parasitism [PDF]
, 2016 SUMMARYParasitic nematodes are important and abundant parasites adapted to live a parasitic lifestyle, with these adaptations all aimed at facilitating their survival and reproduction in their hosts.
Hunt, Vicky L +3 more
core +2 more sources
Comparison of the Effects of Native and Commercial Probiotic on Gluten Degradation
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2021 Background and Objectives: The main treatment for celiac disease is a gluten-free diet. Gluten infection occurs in 55%-32% of these patients, which can cause symptoms in these patients.
Elham Rostami +4 more
doaj
Purification, identification and characterisation of the active site of a Seprase-like activity from bovine serum [PDF]
, 2004 The study and identification for the first time of a soluble form of a Seprase activity from bovine serum is presented. To date, this activity has only been reported to be an integral membrane protease but has been known to shed from its membrane.
Aimes +24 more
core +1 more source
Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling [PDF]
, 2017 The Gram-negative anaerobe Porphyromonas gingivalis is associated with chronic periodontitis. Clinical isolates of P. gingivalis strains with high dipeptidyl peptidase 4 (DPP4) expression also had a high capacity for biofilm formation and were more ...
Augustyns, Koen +11 more
core +1 more source
Insight into the exoproteome of the tissue-derived trypomastigote form of trypanosoma cruzi [PDF]
, 2016 The protozoan parasite Trypanosoma cruzi causes Chagas disease, one of the major neglected infectious diseases. It has the potential to infect any nucleated mammalian cell. The secreted/excreted protein repertoire released by T.
Bastos, Izabela M D +7 more
core +3 more sources
Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A [PDF]
Pharmacological Research, 2020 Prolyl oligopeptidase (PREP) is a serine protease that has been studied particularly in the context of neurodegenerative diseases for decades but its physiological function has remained unclear. We have previously found that PREP negatively regulates beclin1-mediated macroautophagy (autophagy), and that PREP inhibition by a small-molecule inhibitor ...
Urvas Lauri +7 more
openaire +4 more sources
The complete genome of Zunongwangia profunda SM-A87 reveals its adaptation to the deep-sea environment and ecological role in sedimentary organic nitrogen degradation [PDF]
, 2010 Background Zunongwangia profunda SM-A87, which was isolated from deep-sea sediment, is an aerobic, gram-negative bacterium that represents a new genus of Flavobacteriaceae.
Qi-Long Qin +9 more
core +2 more sources
Achieving Functionality Through Modular Build-up: Structure and Size Selection of Serine Oligopeptidases [PDF]
, 2019 Enzymes of the prolyl oligopeptidase family (S9 family) recognize their substrates not only by the specificity motif to be cleaved but also by size - they hydrolyze oligopeptides smaller than 30 amino acids. They belong to the serine-protease family, but
Harmat, Veronika +2 more
core +1 more source
Discovery of covalent prolyl oligopeptidase boronic ester inhibitors
European Journal of Medicinal Chemistry, 2020 Over the past decade, many drug discovery endeavors have been invested in targeting the serine proteases prolyl oligopeptidase (POP) for the treatment of Alzheimer's and Parkinson's disease and, more recently, epithelial cancers. Our research group has focused on the discovery of reversible covalent inhibitors, namely nitriles, to target the catalytic ...
Jessica Plescia +5 more
openaire +3 more sources
A Prolyl Endopeptidase from Flammulina velutipes Degrades Celiac Disease-Inducing Peptides in Grain Flour Samples [PDF]
, 2023 Celiac disease (CD) is an inflammatory disorder of the small intestine. Gluten peptides are supposed to be responsible for the reaction, the best-researched of which is the so-called ‘33-mer’.
Beinhorn, Philine +5 more
core +3 more sources