Results 31 to 40 of about 82,787 (343)

Comparative proteome analysis of the ligamentum flavum of patients with lumbar spinal canal stenosis

JOR SPINE, Volume 5, Issue 4, December 2022., 2022
This study investigated the pathology of thickened ligamentum flavum in patients with lumbar spinal canal stenosis (LSCS) based on protein expression levels using shotgun proteome analysis. The results showed that tissue repair via fibrosis, chondrometaplasia, and amyloid deposits may be important pathologies that occur in the thickened ligamentum ...
Yutaka Yabe, Yoshihiro Hagiwara, Masahiro Tsuchiya, Takashi Minowa, Taro Takemura, Shinya Hattori, Shinichirou Yoshida, Takahiro Onoki, Keisuke Ishikawa   +8 more
wiley   +1 more source

Discovery and Differential Processing of HLA Class II-Restricted Minor Histocompatibility Antigen LB-PIP4K2A-1S and Its Allelic Variant by Asparagine Endopeptidase [PDF]

, 2020
Minor histocompatibility antigens are the main targets of donor-derived T-cells after allogeneic stem cell transplantation. Identification of these antigens and understanding their biology are a key requisite for more insight into how graft vs.
Bausenwein, Judith, Falkenburg, J. H. Frederik, Griffioen, Marieke, Honders, Maria W., Kremer, Andreas E., Kremer, Anita N., Kretschmann, Sascha, Lurvink, Ellie, Mackensen, Andreas, Mazzeo, Daniela, Rutten, Caroline E., van Bergen, Cornelis A. M., van der Meijden, Edith, Watts, Colin   +13 more
core   +2 more sources

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

Protein Hydrolysis and Glycosylation as Strategies to Produce Bioactive Ingredients from Unmarketable Prawns

Foods, 2021
The present work shows a procedure to valorize non-commercial boiled shrimp to produce functional ingredients, using a combined treatment based on enzymatic hydrolysis and subsequent glycation under mild conditions.
Joaquín Gómez-Estaca, Irene Albertos, Ana Belén Martín-Diana, Daniel Rico, Óscar Martínez-Álvarez   +4 more
doaj   +1 more source

High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota

Cells, 2021
The relationship between retinal disease, diet, and the gut microbiome has shown increasing importance over recent years. In particular, high-fat diets (HFDs) are associated with development and progression of several retinal diseases, including age ...
David Dao, Bingqing Xie, Urooba Nadeem, Jason Xiao, Asad Movahedan, Mark D’Souza, Vanessa Leone, Seenu M. Hariprasad, Eugene B. Chang, Dinanath Sulakhe, Dimitra Skondra   +10 more
doaj   +1 more source

Structure of the γ-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-γ-D-Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases. [PDF]

, 2010
Dipeptidyl-peptidase VI from Bacillus sphaericus and YkfC from Bacillus subtilis have both previously been characterized as highly specific γ-D-glutamyl-L-diamino acid endopeptidases. The crystal structure of a YkfC ortholog from Bacillus cereus (BcYkfC)
Abdubek, Polat, Astakhova, Tamara, Axelrod, Herbert L, Bakolitsa, Constantina, Cai, Xiaohui, Carlton, Dennis, Chen, Connie, Chiu, Hsiu Ju, Chiu, Michelle, Clayton, Thomas, Das, Debanu, Deacon, Ashley M, Deller, Marc C, Duan, Lian, Ellrott, Kyle, Elsliger, Marc André, Farr, Carol L, Feuerhelm, Julie, Godzik, Adam, Grant, Joanna C, Grzechnik, Anna, Han, Gye Won, Hodgson, Keith O, Jaroszewski, Lukasz, Jin, Kevin K, Klock, Heath E, Knuth, Mark W, Kozbial, Piotr, Krishna, S Sri, Kumar, Abhinav, Lam, Winnie W, Lesley, Scott A, Marciano, David, Miller, Mitchell D, Morse, Andrew T, Nigoghossian, Edward, Nopakun, Amanda, Okach, Linda, Puckett, Christina, Reyes, Ron, Tien, Henry J, Trame, Christine B, van den Bedem, Henry, Weekes, Dana, Wilson, Ian A, Wooley, John, Wooten, Tiffany, Xu, Qingping, Yeh, Andrew   +48 more
core   +3 more sources

Structural basis of peptidoglycan endopeptidase regulation

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Bacteria digest their cell wall following exposure to antibiotics like penicillin. The endopeptidases (EPs) are among the proteins that catalyze cell wall digestion processes after antibiotic exposure, but we do not understand how these ...
Jung-Ho Shin, A. Sulpizio, A. Kelley, Laura Alvarez, S. Murphy, L. Fan, Felipe Cava, Y. Mao, M. Saper, Tobias Doerr   +9 more
semanticscholar   +1 more source

Genetic Evidence for Distinct Functions of Peptidoglycan Endopeptidases in Escherichia coli

Frontiers in Microbiology, 2020
Peptidoglycan (PG) is an essential component of the bacterial exoskeleton that plays a pivotal role in the maintenance of cell shape and resistance to cell lysis under high turgor pressures.
Si Hyoung Park, Yung Jae Kim, Han Byeol Lee, Yeong-Jae Seok, Chang-Ro Lee   +4 more
doaj   +1 more source

The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity [PDF]

, 2013
Prolyl oligopeptidase (POP) has emerged as a drug target for neurological diseases. A flexible loop structure comprising loop A (res. 189–209) and loop B (res. 577–608) at the domain interface is implicated in substrate entry to the active site.
Brandt, Brunger, Bryan, Cornish-Bowden, Cruickshank, Cunningham, Dean Rea, DeLano, Di Daniel, Duggleby, Ellman, Fuxreiter, Fülöp, Fülöp, García-Horsman, Glassoe, Harmat, Ilona Szamosi, Jalkanen, Jones, Juhász, Kabsch, Kamei, Kaszuba, Kichik, Károly Módos, Leatherbarrow, Li, Liu, Luiz Juliano, László Polgár, Mentlein, Moreno-Baylach, Murshudov, Myöhänen, Nolte, O'Reilly, Odaka, Perrakis, Polgár, Polgár, Polgár, Polgár, Project, Puttonen, Rea, Read, Schulz, Schulz, Shan, Shishido, Szeltner, Szeltner, Szeltner, Szeltner, Szeltner, Szeltner, Tarrago, Toide, Tünde Juhász, Vilmos Fülöp, Williams, Yoshimoto, Zoltán Szeltner   +63 more
core   +1 more source

Identification of regulatory variants of carboxylesterase 1 (CES1): A proof‐of‐concept study for the application of the Allele‐Specific Protein Expression (ASPE) assay in identifying cis‐acting regulatory genetic polymorphisms

PROTEOMICS, Volume 23, Issue 1, January 2023., 2023
Abstract It is challenging to study regulatory genetic variants as gene expression is affected by both genetic polymorphisms and non‐genetic regulators. The mRNA allele‐specific expression (ASE) assay has been increasingly used for the study of cis‐acting regulatory variants because cis‐acting variants affect gene expression in an allele‐specific ...
Lucy Her, Jian Shi, Xinwen Wang, Bing He, Logan S. Smith, Hui Jiang, Hao‐Jie Zhu   +6 more
wiley   +1 more source