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Schizophrenia endophenotypes as treatment targets
Expert Opinion on Therapeutic Targets, 2007 Schizophrenia is a complex disorder that encompasses several clinical symptom domains and functional impairments. Existing treatments are meager, effective only against positive symptoms without benefiting negative symptoms and functional impairments. The drug discovery process has focused mostly on targeting D2 dopamine receptors.openaire +2 more sourcesDiscounting of Delayed Rewards as an Endophenotype
Biological Psychiatry, 2015 The article by Anokhin et al. (1) in this issue of Biological Psychiatry provides strong evidence of the heritability of the neurobehavioral decision process referred to as the discounting of delayed rewards, or temporal discounting (i.e., the devaluation of a reward as a function of delay to its delivery) (2). Using a standard psychophysical titration openaire +2 more sourcesEmotional endophenotypes in evolutionary psychiatry
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2006 Evolutionary psychiatry emerged from the conceptual successes of sociobiology and evolutionary psychology. It will need to avoid the many mistakes that biology-free Evolutionary Psychology has been prey to. It should not ignore the wealth of information that exists between the phenotypic expression of symptoms and the genotypic sources of core brain ...openaire +2 more sourcesEndophenotypes
2013 Tony Charman, Susan Hepburn, Moira Lewis, Moira Lewis, Amanda Steiner, Sally J. Rogers, Annemarie Elburg, Moira Lewis, Frances L. Kohl, Jeffrey Danforth, Erin Rotheram-Fuller, Janine Robinson, Marjorie H. Charlop, Catherine A. Miltenberger, Alissa L. Greenberg, Pamela Brucker, Michelle Lestrud, Arlette Cassidy, Michele Goyette-Ewing, Rita Jordan, Jessica Rohrer, Jessica Rohrer, Fred R. Volkmar, Benjamin Aaronson, Benjamin Aaronson, Kristin Ruedel, Adam Feinstein, John W. Thomas, Francesca Happé, Dawn Vogler-Elias, Sander Begeer, Liz Pellicano, Walter Gilliam, Nurit Yirmiya, Ifat Seidman, Brian Reichow, Paul Wehman, Paul Wehman, Pamela Targett, Irma Isasa, Paul El-Fishawy, Cora Mukerji, Laurent Mottron, James C. McPartland, Paul Cavanagh, Ernst VanBergeijk, Fred R. Volkmar, Christine Barthold, Abha R. Gupta, Lisa Croen, Thomas Fernandez, Gregory Barnes, Reet Sidhu, Roberto Tuchman, Alex Bonnin, Diane M. Lickenbrock, Kai Wang, Josh Pritchard, Mark Malady, Michael J. Crowley, John Molteni, Carolyn A. Doyle, Christopher McDougle, Susan A. Mason, Pat Walsh, Tara J. Glennon, Kevin A. Pelphrey, Benjamin Aaronson, Benjamin Aaronson, Michael Miklos, Marjorie Solomon, Diane M. Lickenbrock, Hope Morris, Hope Morris, Hope Morris, Maura Moyle, Steven Long, Brian Reichow, Fred R. Volkmar, Mary Jane Weiss, Bonnie Auyeung, Michael Lombardo, Rebecca Knickmeyer, Simon Baron-Cohen, Atsushi Senju, Lindsey Sterling, Frederick Shic +86 moreopenaire +1 more source[Endophenotypes in Psychiatry].
Vertex (Buenos Aires, Argentina), 2018 We review the concept of endophenotype, and its relationship with related terms in use in the scientific literature, including "biomarker" and "intermediate phenotype". We then explain the importance of the concept in current psychiatry research. Specifically, we focus in the potential importance of endophenotypes in both disentangling the genetic ...openaire +1 more sourceEndophenotype
2010 Bart Ellenbroek, Alfonso Abizaid, Shimon Amir, Martina de Zwaan, Sarah Parylak, Pietro Cottone, Eric P. Zorrilla, Lawrence H. Price, Ben J. Harrison, Christos Pantelis, Lawrence H. Price, Sophie Tambour, John C. Crabbe, Ian P. Stolerman, Nicola Simola, Micaela Morelli, Michael H. Bloch, Sarah Morgan, Angus Mackay, Gary Remington, Sidney H. Kennedy, Sakina J. Rizvi, Giovanni Hernandez, Peter Shizgal, Mitul A. Mehta, Ennio Esposito, Roberto William Invernizzi, Darren R. Christensen, Warren K. Bickel, Lynette C. Daws, Anne M. Andrews, Greg A. Gerhardt, Lawrence H. Price, Mischa de Rover, Sander Nieuwenhuis, Peter H. Boeijinga, Victoria L. Harvey, Anthony H. Dickenson, Peter Verheart, Per Svenningsson, Per E. Andrén, Antonio Pádua Carobrez, Grasielle C. Kincheski, Leandro J. Bertoglio, Kim Wolff, Iván Izquierdo, Lia Rejane M. Bevilaqua, Martin Cammarota, David H. Zald, Oliver Stiedl, Sven Ove Ögren, Joseph Zohar, Alan J. Budney, Oliver Stiedl, Sven Ove Ögren, Cecilia J. Hillard, Alfonso Abizaid, Shimon Amir, Josee E. Leysen, Samuel B. Hutton, Michael M. Morgan, MacDonald J. Christie, Paul Willner, Michael M. Morgan, MacDonald J. Christie, Martina de Zwaan, Jason C. G. Halford, Peter Riederer, Siegfried Hoyer, Francis C. Colpaert, Michael M. Morgan, MacDonald J. Christie, Michael M. Morgan, MacDonald J. Christie, Daniel Hoyer, Paul D. Callaghan, Iain S. McGregor, Murray R. Thompson, Kim Wolff, Mary E. Cain, Michael T. Bardo, Christoph Hiemke, Christoph Hiemke, Lawrence S. Wilkinson, Anthony R. Isles, Celia J. A. Morgan, Valerie H. Curran, Victoria L. Harvey, Anthony H. Dickenson, Mark Slifstein, Jos Prickaerts, David E. Nichols, Lawrence H. Price, Marc N. Branch, Mohammed Shoaib, Jill B. Becker, Marilyn E. Carroll, Peter A. Santi, Marilyn E. Carroll, Peter A. Santi, Juan J. López-Ibor, Maria-Inés López-Ibor, Maria-Inés López-Ibor, Juan J. López-Ibor, Berend Olivier, Naheed (Max) Mirza, Seiya Miyamoto, Mohammed Shoaib, Bernard Le Foll, Cyril Höschl, Sander Nieuwenhuis, Mischa de Rover, Mischa de Rover, Sander Nieuwenhuis, David S. Baldwin, Cyril Höschl, Thomas Steckler, Michel Billiard, Linda Lundström, Will Spooren, Silvia Gatti McArthur, Linda Lundström, Silvia Gatti McArthur, Will Spooren, Darrel J. Pemberton, Kim Wolff, Andrea Bari, Josee E. Leysen, Samuel B. Hutton, Amee B. Patel, Kim Fromme, Kim Fromme, Amee B. Patel, Kim Fromme, Amee B. Patel, Kim Fromme, Amee B. Patel, Suzanne H. Mitchell, Harriet de Wit, Matthew I. Palmatier, Rick A. Bevins, Victoria L. Harvey, Anthony H. Dickenson, David S. Tait, Verity J. Brown, W. Wolfgang Fleischhacker, Samuel B. Hutton +146 moreopenaire +1 more source
