Results 121 to 130 of about 4,269 (166)
Endophenotype Best Practices [PDF]
International Journal of Psychophysiology, 2017 This review examines the current state of electrophysiological endophenotype research and recommends best practices that are based on knowledge gleaned from the last decade of molecular genetic research with complex traits. Endophenotype research is being oversold for its potential to help discover psychopathology relevant genes using the types of ...
Stephen M Malone +2 more
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
2018
Endophenotypes are traits that, while genetically related to an illness, are not used for diagnoses (e.g., a symptom). It is unlikely that specific genes directly code for any of our current psychiatric diagnoses. Rather, genes influence neurobiological processes that either increase or decrease risk for mental illness.
David C. Glahn +2 more
openaire +2 more sources
Endophenotypes are traits that, while genetically related to an illness, are not used for diagnoses (e.g., a symptom). It is unlikely that specific genes directly code for any of our current psychiatric diagnoses. Rather, genes influence neurobiological processes that either increase or decrease risk for mental illness.
David C. Glahn +2 more
openaire +2 more sources
Neurology, 2005
Neuroimaging-based endophenotyping is becoming popular. The aim is to discover markers for altered CNS gene expression in nonmanifesting gene carriers for illnesses with reduced penetrance, preclinical gene carriers for illnesses with a late onset, and even healthy subjects with allelic variants possibly related to an increased susceptibility for ...
Meunier, Sabine, Hallett, Mark
openaire +3 more sources
Neuroimaging-based endophenotyping is becoming popular. The aim is to discover markers for altered CNS gene expression in nonmanifesting gene carriers for illnesses with reduced penetrance, preclinical gene carriers for illnesses with a late onset, and even healthy subjects with allelic variants possibly related to an increased susceptibility for ...
Meunier, Sabine, Hallett, Mark
openaire +3 more sources
Neurocognitive Endophenotypes of OCD
2021In this chapter, I address the concept of endophenotypes for obsessive-compulsive disorder (OCD). Endophenotypes are objective and heritable quantitative traits hypothesized to be more biologically tractable than distal clinical phenotypes. This approach has been adopted to gain a better understanding of psychiatric conditions in general.
openaire +4 more sources
2020
Since Gottesman introduced the concept of endophenotypes in schizophrenia research, the endophenotype strategy for understanding the genetics of schizophrenia has been used widely. Endophenotypes are wide-ranging laboratory-based quantitative measures from gene transcripts to neurocognition that show deficits in schizophrenia patients and their first ...
openaire +1 more source
Since Gottesman introduced the concept of endophenotypes in schizophrenia research, the endophenotype strategy for understanding the genetics of schizophrenia has been used widely. Endophenotypes are wide-ranging laboratory-based quantitative measures from gene transcripts to neurocognition that show deficits in schizophrenia patients and their first ...
openaire +1 more source
Endophenotypes in bipolar disorder†
American Journal of Medical Genetics, 2002AbstractThe search for genes in bipolar disorder has provided numerous genetic loci that have been linked to susceptibility to developing the disorder. However, because of the genetic heterogeneity inherent in bipolar disorder, additional strategies may need to be employed to fully dissect the genetic underpinnings.
Robert H, Lenox +2 more
openaire +2 more sources
Endophenotypes as a measure of suicidality
Journal of Applied Genetics, 2012Suicide is thought to result from the harmful interaction of multiple factors that have social, environmental, neurobiological, and genetic backgrounds. Recent studies have suggested that genetic predisposition to suicidal behavior may be independent of the risk of suicide associated to mental disorders, such as affective disorders, schizophrenia, or ...
Dimitry A, Chistiakov +2 more
openaire +2 more sources
2021
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by a complex pathogenesis and very wide clinical phenotypes. To date, a large variety of clinical phenotypes have been grouped into a single diagnosis, and a single therapeutic approach has been used for AD patients with different clinical phenotypes without considering ...
Kwang Hoon Lee, Chang Ook Park
openaire +1 more source
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by a complex pathogenesis and very wide clinical phenotypes. To date, a large variety of clinical phenotypes have been grouped into a single diagnosis, and a single therapeutic approach has been used for AD patients with different clinical phenotypes without considering ...
Kwang Hoon Lee, Chang Ook Park
openaire +1 more source
Neurocognitive endophenotypes for bipolar disorder
Bipolar Disorders, 2008Objectives: Neurocognitive deficits have been proposed as vulnerability markers or endophenotypes for the development of bipolar I disorder (BD I). However, few research studies have examined whether neurocognitive deficits also exist in first‐degree relatives of individuals with BD I.Methods: This prospective study examined neurocognitive function ...
Linda V, Frantom +2 more
openaire +2 more sources
[Temperamental endophenotypes].
L'Encephale, 2013Temperament has been defined as the heritable biologically determined core of personality that remains stable throughout the life span and establishes the baseline level of reactivity, mood, and energy of a person. If the link between temperament and mental disorder goes back to the Greco-Roman medicine, Kraepelin was among the first authors to pay ...
J-M, Azorin +10 more
openaire +1 more source