Endoplasmic reticulum associated degradation preserves neurons viability by maintaining endoplasmic reticulum homeostasis [PDF]
Frontiers in NeuroscienceEndoplasmic reticulum-associated degradation (ERAD) is a principal quality-control mechanism responsible for targeting misfolded ER proteins for cytosolic degradation.
Shuangchan Wu +7 more
doaj +4 more sources
Regulation of Endoplasmic Reticulum-Associated Protein Degradation (ERAD) by Ubiquitin [PDF]
Cells, 2014 Quality control of protein folding inside the endoplasmic reticulum (ER) includes chaperone-mediated assistance in folding and the selective targeting of terminally misfolded species to a pathway called ER-associated protein degradation, or simply ERAD ...
Leticia Lemus, Veit Goder
doaj +9 more sources
Estrogens Promote Misfolded Proinsulin Degradation to Protect Insulin Production and Delay Diabetes [PDF]
Cell Reports, 2018 Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and
Beibei Xu +12 more
doaj +3 more sources
Lipid biosynthesis perturbation impairs endoplasmic reticulum-associated degradation. [PDF]
J Biol Chem, 2023 ABSTRACTThe relationship between lipid homeostasis and protein homeostasis (proteostasis) is complex and remains incompletely understood. We conducted a screen for genes required for efficient degradation ofDeg1-Sec62, a model aberrant translocon-associated substrate of the endoplasmic reticulum (ER) ubiquitin ligase Hrd1, inSaccharomyces cerevisiae ...
Turk SM +20 more
europepmc +3 more sources
TorsinA participates in endoplasmic reticulum-associated degradation [PDF]
Nature Communications, 2013 TorsinA is an \(AAA^+\) ATPase located within the lumen of the endoplasmic reticulum and nuclear envelope, with a mutant form causing early onset torsion dystonia (DYT1).
Armata, Ioanna A. +15 more
core +5 more sources
Endoplasmic reticulum-associated degradation of glycoproteins in plants [PDF]
Frontiers in Plant Science, 2012 In all eukaryotes the endoplasmic reticulum (ER) has a central role in protein folding and maturation of secretory and membrane proteins. Upon translocation into the ER polypeptides are immediately subjected to folding and modifications involving the ...
Silvia eHüttner, Richard eStrasser
doaj +3 more sources
Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications [PDF]
Acta Pharmaceutica Sinica B, 2020 The hepatic endoplasmic reticulum (ER)-anchored cytochromes P450 (P450s) are mixed-function oxidases engaged in the biotransformation of physiologically relevant endobiotics as well as of myriad xenobiotics of therapeutic and environmental relevance ...
Doyoung Kwon +2 more
doaj +4 more sources
Endoplasmic reticulum-associated degradation mitigates atherosclerosis by maintaining cellular homeostasis [PDF]
Frontiers in PhysiologyAtherosclerosis (AS) is a fatal cardiovascular disease (CVD) that threatens human health. Although there are some treatments for AS in clinical practice, cardiovascular complications such as myocardial ischemia and hypoxia, heart failure, and stroke ...
Haiming Niu +8 more
doaj +2 more sources
Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection [PDF]
eLife, 2021 Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4–CD8–double negative (DN) thymocytes to generate αβ T cells in the thymus.
Xia Liu +13 more
doaj +2 more sources
Golgi Alpha1,2-Mannosidase IA Promotes Efficient Endoplasmic Reticulum-Associated Degradation of NKCC2 [PDF]
Cells, 2021 Mutations in the apically located kidney Na-K-2Cl cotransporter NKCC2 cause type I Bartter syndrome, a life-threatening kidney disorder. We previously showed that transport from the ER represents the limiting phase in NKCC2 journey to the cell surface ...
Sylvie Demaretz +5 more
doaj +2 more sources