Results 131 to 140 of about 9,109,989 (294)
Advanced Science, EarlyView.LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li +5 more
wiley +1 more source
The physiological functions of mammalian endoplasmic oxidoreductin 1: on disulfides and more [PDF]
, 2012 Significance: The oxidative process of disulfide-bond formation is essential for the folding of most secretory and membrane proteins in the endoplasmic reticulum (ER).
Ramming, Thomas +1 more
core +1 more source
Advanced Science, EarlyView.In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang +19 more
wiley +1 more source
Fibrillar aggregations of pathogenic pro-vasopressin mutants [PDF]
, 2009 Diabetes insipidus is a disregulation of water homeostasis characterized by large fluid turnover in the kidney. Water homeostasis is regulated by the hormone vasopressin by increasing reapsorption of water in the renal collecting duct. Autosomal dominant
Birk, Julia
core +1 more source
Advanced Science, EarlyView.Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang +9 more
wiley +1 more source
Ricin trafficking in plant and mammalian cells [PDF]
, 2011 Ricin is a heterodimeric plant protein that is potently toxic to mammalian and many other eukaryotic cells. It is synthesized and stored in the endosperm cells of maturing Ricinus communis seeds (castor beans).
Lord, Mike +3 more
core +1 more source
Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3
Advanced Science, EarlyView.This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao +6 more
wiley +1 more source
The protein translocation systems in plants - composition and variability on the example of Solanum lycopersicum [PDF]
, 2013 Background: Protein translocation across membranes is a central process in all cells. In the past decades the molecular composition of the translocation systems in the membranes of the endoplasmic reticulum, peroxisomes, mitochondria and chloroplasts ...
Fragkostefanakis, Sotirios +13 more
core +1 more source
Nature Communications, 2019 Human cytomegalovirus (HCMV) can persist for the life of a host in the face of robust immune responses owing to a wide range of immune evasion strategies.
Xiaoyang Liu +9 more
doaj +1 more source
Rheumatoid arthritis as a hyper-endoplasmic-reticulum-associated degradation disease.
Arthritis research & therapy, 2005 We introduce Synoviolin as a novel pathogenic factor in rheumatoid arthritis (RA). Experimental studies indicate that this endoplasmic reticulum (ER)-resident E3 ubiquitin ligase has important functions in the ER-associated degradation (ERAD) system, an essential system for ER homeostasis.
Yamasaki, Satoshi +4 more
openaire +2 more sources