Results 111 to 120 of about 636,928 (251)

Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways

TIBS -Trends in Biochemical Sciences. Regular ed, 2018
Endoplasmic reticulum (ER)-associated degradation (ERAD) and the unfolded protein response (UPR) are two key quality-control machineries in the cell.
Jiwon Hwang, Ling Qi
semanticscholar   +1 more source

Endoplasmic reticulum stress promoting caspase signaling pathway-dependent apoptosis contributes to bone cancer pain in the spinal dorsal horn

Molecular Pain, 2019
Background Management of bone cancer pain is difficult because of its complex mechanisms, which has a major impact on the quality of patients’ daily life.
Qiuli He, Tingting Wang, Huadong Ni, Qianying Liu, Kang An, Jiachun Tao, Yajing Chen, Longsheng Xu, Chunyan Zhu, Ming Yao   +9 more
doaj   +1 more source

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

Nature Cell Biology, 2019
Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the mitochondrial matrix.
Amado Carreras-Sureda, F. Jaña, H. Urra, S. Durand, D. E. Mortenson, Alfredo I Sagredo, Galdo Bustos, Younis Hazari, E. Ramos-Fernández, M. Sassano, Philippe Pihán, A. V. van Vliet, Matías González-Quiroz, Angie K Torres, Cheril Tapia-Rojas, M. Kerkhofs, Rubén Vicente, R. Kaufman, N. Inestrosa, Christian Gonzalez-Billault, R. Wiseman, P. Agostinis, G. Bultynck, F. Court, G. Kroemer, J. Cardenas, C. Hetz   +26 more
semanticscholar   +1 more source

The isolation and characterisation of temperature-dependent Ricin A chain molecules in Saccharomyces cerevisiae. [PDF]

, 2007
Ricin is a heterodimeric plant protein that is potently toxic to mammalian cells. Toxicity results from the catalytic depurination of eukaryotic ribosomes by ricin A chain (RTA) that follows toxin endocytosis to, and translocation across, the ...
Ladds, Graham, Moffat, K G, Allen, Stuart C H, Fulop, V, Moore, Katherine A. H., Marsden, Catherine J., Marsden, C J, Ladds, G, Roberts, L M, Lord, Mike, Lord, J M, Allen, Stuart C. H., Roberts, L. M. (Lynne M.), Moffat, Kevin G., Fülöp, Vilmos, Moore, K A H   +15 more
core   +1 more source

Location matters: the endoplasmic reticulum and protein trafficking in dendrites

Biological Research, 2011
Neurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles are still poorly understood.
Omar A Ramírez, Steffen Härtel, Andrés Couve   +2 more
doaj  

Characterization of endoplasmic reticulum from castor bean and the cloning of a plant phosphatase: a basis for comprehensive plant organelle proteomics research [PDF]

, 2000
The plant endoplasmic reticulum is the location of storage oil and membrane lipid assembly, and for fatty acid modifying reactions (desaturation, elongation, hydroxylation). It therefore represents a source of enzymes involved in these processes. Many of
Maltman, Daniel James
core  

Intracellular glutathione pools are heterogeneously concentrated [PDF]

, 2013
Glutathione is present in millimolar concentrations in the cell, but its relative distribution among cellular compartments remains elusive. We have chosen the endoplasmic reticulum (ER) as an example organelle to study compartment-specific glutathione ...
Christine Tachibana, Jakob Rahr Winther, Rahr Winther, Jakob, Winther, Jakob R., Appenzeller-Herzog, Christian, Davide Montero, Tachibana, Christine, Christian Appenzeller-Herzog, Montero, Davide   +8 more
core   +1 more source

Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer

Cell, 2017
SUMMARY Malignant cells utilize diverse strategies that enable them to thrive under adverse conditions while simultaneously inhibiting the development of anti-tumor immune responses.
J. Cubillos-Ruiz, Sarah Bettigole, L. Glimcher   +2 more
semanticscholar   +1 more source

ER‐phagy: shaping up and destressing the endoplasmic reticulum

The FEBS Journal, 2019
The endoplasmic reticulum (ER) network has central roles in metabolism and cellular organization. The ER undergoes dynamic alterations in morphology, molecular composition and functional specification.
S. Wilkinson
semanticscholar   +1 more source

Syntaxin 16 and syntaxin 5 are required for efficient retrograde transport of several exogenous and endogenous cargo proteins [PDF]

, 2007
Retrograde transport allows proteins and lipids to leave the endocytic pathway to reach other intracellular compartments, such as trans-Golgi network (TGN)/Golgi membranes, the endoplasmic reticulum and, in some instances, the cytosol. Here, we have used
Falguières, Thomas, Roberts, L., Smith, Daniel C., Lord, J., Fradagrada, Alexandre, Amessou, Mohamed, Amessou, M., Johannes, Ludger, Fradagrada, A., Falguieres, T., Lord, Mike, Roberts, L. M. (Lynne M.), Lamaze, Christophe, Lamaze, C., Johannes, L., Smith, D.   +15 more
core   +1 more source