Results 131 to 140 of about 636,928 (251)

Exosomes derived from microglia overexpressing miR-124-3p alleviate neuronal endoplasmic reticulum stress damage after repetitive mild traumatic brain injury

Neural Regeneration Research
[INLINE:1] We previously reported that miR-124-3p is markedly upregulated in microglia-derived exosomes following repetitive mild traumatic brain injury.
Yan Wang, Dai Li, Lan Zhang, Zhenyu Yin, Zhaoli Han, Xintong Ge, Meimei Li, Jing Zhao, Shishuang Zhang, Yan Zuo, Xiangyang Xiong, Han Gao, Qiang Liu, Fanglian Chen, Ping Lei   +14 more
doaj   +1 more source

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.

Genes & Development, 1999
All eukaryotic cells have an extensive membranous labyrinth network of branching tubules and flattened sacs called the endoplasmic reticulum (ER). Approximately one-third of all cellular proteins are translocated into the lumen of the ER where post ...
R. Kaufman
semanticscholar   +1 more source

The slow sarco/endoplasmic reticulum Ca2+-ATPase declines independently of slow myosin in soleus muscle of diabetic rats [PDF]

, 2009
The sarcoplasmic reticulum Ca2+-ATPase (SERCA) isoforms are normally expressed in coordination with the corresponding myosin heavy chain (MyHC) isoforms in the fibers of skeletal muscle but this coordination is often disrupted in pathological conditions.
Rácz, Gábor, Zádor, Ernő, Vér, Ágota, Szabó, András   +3 more
core   +2 more sources

Endoplasmic reticulum stress in lung cancer

Frontiers in Oncology
Endoplasmic reticulum is the primary site of eukaryotic cells involved in biosynthesis, lipid metabolism, glucose metabolism, protein folding and secretion.
Donghuan Zhang, Lanlan Lin, Hui Jin, Huajun Mao, Luying Wang, Wenwen Ma, Zhenghong Lao   +6 more
doaj   +1 more source

MAM-mediated mitophagy and endoplasmic reticulum stress: the hidden regulators of ischemic stroke

Frontiers in Cellular Neuroscience
Ischemic stroke (IS) is the predominant subtype of stroke and a leading contributor to global mortality. The mitochondrial-associated endoplasmic reticulum membrane (MAM) is a specialized region that facilitates communication between the endoplasmic ...
Ziyi Jia, Hongtao Li, Ke Xu, Ruobing Li, Siyu Yang, Long Chen, Qianwen Zhang, Shulin Li, Xiaowei Sun   +8 more
doaj   +1 more source

Mechanisms linking glucotoxicity to the development of insulin resistance: a role for the endoplasmic reticulum stress [PDF]

, 2010
Aims/hypothesis: Glucosamine, generated during hyperglycaemia, causes insulin resistance in different cells. Here we sought to evaluate the possible role of ER stress in the induction of insulin-resistance by glucosamine in skeletal muscle cells. Methods:
Iadicicco, Claudia
core   +1 more source

TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells

Cell Death Discovery
The release of Ca2+ ions from endoplasmic reticulum calcium stores is a key event in a variety of cellular processes, including gene transcription, migration and proliferation.
Alice H. L. Bong, Mélanie Robitaille, Sichun Lin, Amy McCart-Reed, Michael Milevskiy, Stéphane Angers, Sarah J. Roberts-Thomson, Gregory R. Monteith   +7 more
doaj   +1 more source

Endoplasmic reticulum stress, autophagy, neuroinflammation, and sigma 1 receptors as contributors to depression and its treatment

Neural Regeneration Research
The etiological factors contributing to depression and other neuropsychiatric disorders are largely undefined. Endoplasmic reticulum stress pathways and autophagy are well-defined mechanisms that play critical functions in recognizing and resolving ...
Chika Fujii, Charles F Zorumski, Yukitoshi Izumi   +2 more
doaj   +1 more source

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

Nature, 2008
Hiroki Ishikawa, G. Barber
semanticscholar   +1 more source

The role of endoplasmic reticulum in human adipose tissue [PDF]

Adipose tissue plays a central role in the regulation of metabolic homeostasis. In obesity adipocytes are challenged by many insults: surplus energy, inflammation, insulin resistance and considerable endoplasmic reticulum (ER) stress.
Alhusaini, S. (Saif)
core