Results 171 to 180 of about 744,619 (389)

Chemoselective Characterization of New Extracellular Matrix Deposition in Bioengineered Tumor Tissues

open access: yesAdvanced Materials, EarlyView.
Understanding the bi‐directional crosstalk between cells and their surrounding extracellular matrix (ECM) is critical for tissue engineering. This study presents a chemoselective strategy for proteomic profiling of newly deposited ECM from resident cells.
Zihan Ling   +9 more
wiley   +1 more source

Effect of Phosphate Ions on Biophysical Properties of Rat Hepatocytes Endoplasmic Reticulum Potassium Channel

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2012
BACKGROUND AND OBJECTIVE: Rough endoplasmic reticulum is important organelle that plays a role in the regulation of a range of functions. Potassium channels in the endoplasmic reticulum membrane were recently reported that its physiological role is ...
H Sepehri,, M Ashrafpour
doaj  

Targeting of the prion protein to the cytosol: mechanisms and consequences

open access: yes, 2010
Prion diseases are characterized by the conformational transition of the cellular prion protein (PrPC) into an aberrant protein conformer, designated scrapie-prion protein (PrPSc).
Miesbauer, M.   +3 more
core  

The Bionic Interface: Considering the Material Mediated Electrical Stimulation of Stem Cells

open access: yesAdvanced Materials, EarlyView.
Electrical stimulation directs stem cell fate in tissue engineering. Cellular responses are influenced by membrane properties, intrinsic cell state, material charge‐transport characteristics, and the applied electrical signal. Additionally, a material’s ability to inject, store, and redistribute charge further modulates these responses.
Kaiwen Zhang   +6 more
wiley   +1 more source

The physiological role of the unfolded protein response in the nervous system

open access: yesNeural Regeneration Research
The unfolded protein response (UPR) is a cellular stress response pathway activated when the endoplasmic reticulum, a crucial organelle for protein folding and modification, encounters an accumulation of unfolded or misfolded proteins.
Shuangchan Wu, Wensheng Lin
doaj   +1 more source

The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress. [PDF]

open access: yes, 2011
Excessive demands on the protein-folding capacity of the endoplasmic reticulum (ER) cause irremediable ER stress and contribute to cell loss in a number of cell degenerative diseases, including type 2 diabetes and neurodegeneration.
Austgen, Kathryn   +4 more
core  

Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity

open access: yesAdvanced Materials, EarlyView.
This study introduces glutathione‐stabilized gold nanoparticles for targeted lithium delivery (LiG‐AuNPs), enabling the controlled modulation of Glycogen Synthase Kinase‐3 (GSK‐3β). These non‐toxic, 2‐nm particles release lithium intracellularly, effectively inhibiting GSK‐3β in the brain without significant plasma lithium alterations.
Antonio Buonerba   +20 more
wiley   +1 more source

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