Results 271 to 280 of about 481,400 (346)

Mortalin and PINK1/Parkin‐Mediated Mitophagy Represent Ovarian Cancer‐Selective Targets for Drug Development

Advanced Science, EarlyView.
Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra, Justin Garland, Rajani Rai, Donghua Zhao, Charuksha Walgama, Sadagopan Krishnan, Andrew T. Long, Tongzu Liu, Laura Adhikari, Doris M. Benbrook   +9 more
wiley   +1 more source

CHPG's role in regulating apoptosis in heat-stressed microglia through endoplasmic reticulum stress: A new perspective☆. [PDF]

IBRO Neurosci Rep
He YX, Zhang ZQ, Zheng XX, Huang F, He G, Yu XC, Xu AC.   +6 more
europepmc   +1 more source

BRD4 Signaling Maintains the Differentiated State of β Cells

Advanced Science, EarlyView.
The comprehensive exploration revealed the critical role of BRD4 in β cells. BRD4 plays a fundamental role in maintaining β cell differentiation because both long‐term and acute BRD4 deficiency result in a reduction in insulin secretion and downregulation of differentiation markers.
Fuqiang Liu, Guang Liu, Jia Song, Yujing Sun, Mengmeng Yang, Hualin Liu, Hongkai Zhao, Jiamu Chen, Qincheng Qiao, Siyue Li, Chenglong Yu, Jingru Qu, Ying Zou, Tixiao Wang, Jidong Liu, Lei Zhao, Huihui Tian, Tao Huang, Manna Zhang, Li Chen, Ruxing Zhao, Yuanyuan Du, Xinguo Hou   +22 more
wiley   +1 more source

Effects of endurance exercise training on endoplasmic reticulum stress in pancreatic islets of obese mice. [PDF]

Braz J Med Biol Res
Marconato-Júnior E, Soares GM, Rodrigues-Dos-Santos K, Araujo TDR, Vettorazzi JF, Zangerolamo L, Costa-Junior JM, Carneiro EM, Boschero AC, Barbosa HCL.   +9 more
europepmc   +1 more source

Characterization of Ca²⁺ Transport in Purified Endoplasmic Reticulum Membrane Vesicles from Lepidium sativum L. Roots

, 1984
Thomas J. Buckhout
openalex   +2 more sources

UTX Responds to Nanotopography to Suppress Macrophage Inflammatory Response by Remodeling H3K27me3 Modification

Advanced Science, EarlyView.
Compared with those on the pTi surface, macrophages on the TNTs surface present reduced myosin II contractility, which facilitates the nuclear translocation of the UTX. This reduction decreases the enrichment of the repressive H3K27me3 histone modification at the Abca1 gene locus, which promotes the transcription and protein expression of ABCA1 ...
Hengji Jia, He Zhang, Dingqiang Mo, Bo Xie, Hongdou Qiao, Tao Chen, Haoyue Song, Xinxin Xu, Sheng Yang   +8 more
wiley   +1 more source

Correction: BMDM-derived ORP8 suppresses lipotoxicity and inflammation by relieving Endoplasmic reticulum stress in mice with MASH. [PDF]

Mol Med
Chen Y, Xie K, Chen C, Wang X, Ma C, Huang Z, Jiao Y, Yu W.   +7 more
europepmc   +1 more source

YTHDC1 Is Essential for Postnatal Liver Development and Homeostasis

Advanced Science, EarlyView.
This study identifies YTHDC1 as a key regulator of postnatal liver development and disease. Hepatocyte‐specific deletion of Ythdc1 impairs hepatocyte maturation, causing liver injury, contributing to nonalcoholic steatohepatitis and hepatocellular carcinoma.
Xinzhi Li, Xueying Li, Chunhong Liu, Zhenzhi Li, Kaixin Ding, Yuxin Wang, Ning Gu, Liwei Xie, Zheng Chen   +8 more
wiley   +1 more source

Monitoring Glutathione Content of the Endoplasmic Reticulum under Scrap Leather-Induced Endoplasmic Reticulum Stress via an Endoplasmic Reticulum-Targeted Two-Photon Fluorescent Probe. [PDF]

Anal Chem
Song X, Wang X, Wang Y, Hao Y, Li C, Chai L, Ren H, Chen J, Hu W, James TD.   +9 more
europepmc   +1 more source

Chemigenetic Encoding of Fluorescent Dyes Enables High‐Fidelity and Wash‐Free Imaging of Proteins in Live Cells

Advanced Science, EarlyView.
This study develops a chemigenetic strategy that combines synthetic dyes with genetically encoded fluorescence for high‐fidelity, no‐wash protein imaging. By utilizing FRET between fluorescent proteins and Halo‐tag dyes, this system ensures that only target‐bound dyes fluoresce, effectively suppressing background signals and enhancing the signal‐to ...
Xuelian Zhou, Lu Miao, Ning Xu, Yonghui Chen, Jinjing Shi, Jinhua Zhou, Guangying Wang, Qinglong Qiao, Zhaochao Xu   +8 more
wiley   +1 more source