Results 101 to 110 of about 462,885 (376)
Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells
Molecular Metabolism, 2017 Background: Pancreatic β cell dysfunction and death are central in the pathogenesis of most if not all forms of diabetes. Understanding the molecular mechanisms underlying β cell failure is important to develop β cell protective approaches.
Miriam Cnop +3 more
doaj +1 more source
Interferon-gamma inducible protein 10 (IP10) induced cisplatin resistance of HCC after liver transplantation through ER stress signaling pathway. [PDF]
, 2015 Tumor recurrence remains an obstacle after liver surgery, especially in living donor liver transplantation (LDLT) for patients with hepatocellular carcinoma (HCC).
Geng, Wei +9 more
core +5 more sources
Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
wiley +1 more source
Endoplasmic reticulum stress in periimplantation embryos [PDF]
Clinical and Experimental Reproductive Medicine, 2015 Stress coping mechanisms are critical to minimize or overcome damage caused by ever changing environmental conditions. They are designed to promote cell survival. The unfolded protein response (UPR) pathway is mobilized in response to the accumulation of unfolded proteins, ultimately in order to regain endoplasmic reticulum (ER) homeostasis.
Myung Chan Gye, Marek Michalak
openaire +3 more sources
PLoS ONE, 2014 The E3 ubiquitin ligase HRD1 is found in the endoplasmic reticulum membrane of brain neurons and is involved in endoplasmic reticulum-associated degradation. We previously demonstrated that suppression of HRD1 expression in neurons causes accumulation of
Ryo Saito +6 more
doaj +1 more source
EXPRESSION OF ENDOPLASMIC RETICULUM OXIDOREDUCTASES (EROS) AND THEIR ROLE IN THE GI TRACT [PDF]
, 2012 It has been shown that some ER redox enzymes are differentially expressed in stomach and oesophagus tissue. The tissues of the gastrointestinal system, which are subject to external changes of environment during the process of digestion, represent a ...
WATSON, GRAEME
core
Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
FEBS Open Bio, EarlyView.The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu +12 more
wiley +1 more source
Endoplasmic Reticulum Stress Response [PDF]
, 2011 The endoplasmic reticulum (ER) is a key organelle that serves as the gateway for newly synthesized proteins into the secretory pathway. Following synthesis, secretory proteins are exported from the ER to various cellular compartments where they fulfill their inherent biological roles. The correct trafficking of proteins through the secretory pathway is
Pedro A. B. Reis +2 more
openaire +3 more sources
Endoplasmic Reticulum Stress in Disease Pathogenesis [PDF]
Annual Review of Pathology: Mechanisms of Disease, 2007 The endoplasmic reticulum (ER) is the site of synthesis and folding of membrane and secretory proteins, which, collectively, represent a large fraction of the total protein output of a mammalian cell. Therefore, the protein flux through the ER must be carefully monitored for abnormalities, including the buildup of misfolded proteins.
Peter Walter +2 more
openaire +3 more sources
Penfluridol induces endoplasmic reticulum stress leading to autophagy in pancreatic cancer
Tumor Biology, 2017 Pancreatic cancer is one of the most aggressive and difficult to treat cancers. Experimental and clinical evidence suggests that high basal state autophagy in pancreatic tumors could induce resistance to chemotherapy.
Alok Ranjan +4 more
doaj +1 more source