Results 1 to 10 of about 5,197 (301)

Statistical analysis of ENDOR spectra [PDF]

Proceedings of the National Academy of Sciences, 2021
SignificanceStatistical modeling of experimental data is gaining increasing importance in biological science due to the availability of large datasets. Here we present a statistical analysis of electron–nuclear double resonance, a technique that delivers information on the angstrom to nanometer scale around paramagnetic centers in proteins.
Yvo Pokern, Benjamin Eltzner, Stephan F. Huckemann, Clemens Beeken, JoAnne Stubbe, Igor Tkach, Marina Bennati, Markus Hiller   +7 more
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Interpreting tree ensemble machine learning models with endoR.

PLoS Computational Biology, 2022
Tree ensemble machine learning models are increasingly used in microbiome science as they are compatible with the compositional, high-dimensional, and sparse structure of sequence-based microbiome data.
Albane Ruaud, Niklas Pfister, Ruth E Ley, Nicholas D Youngblut   +3 more
doaj   +3 more sources

Increased sensitivity in electron–nuclear double resonance spectroscopy with chirped radiofrequency pulses [PDF]

Magnetic Resonance
Electron–nuclear double resonance (ENDOR) spectroscopy is an EPR technique to detect the nuclear frequency spectra of hyperfine coupled nuclei close to paramagnetic centers, which have interactions that are not resolved in continuous wave EPR spectra and
J. Stropp, N. Wili, N. C. Nielsen, D. Klose   +3 more
doaj   +2 more sources

EPR spectroscopy reveals antioxidant manganese defenses in the Lyme disease pathogen Borrelia burgdorferi [PDF]

mBio
Oxidative stress defense in aerobic bacteria relies on Mn-superoxide dismutase (MnSOD) and antioxidant Mn-metabolite complexes (H-Mn) to quench superoxide radicals (O2•−).
Andrés F. Londoño, Ajay Sharma, Venkatesan Kathiresan, Jared Sealy, Robert P. Volpe, Cene Gostinčar, Utpal Pal, J. Stephen Dumler, Brian M. Hoffman, Michael J. Daly   +9 more
doaj   +2 more sources

Bidentate Substrate Binding Mode in Oxalate Decarboxylase [PDF]

Molecules
Oxalate decarboxylase is an Mn- and O2-dependent enzyme in the bicupin superfamily that catalyzes the redox-neutral disproportionation of the oxalate monoanion to form carbon dioxide and formate.
Alvaro Montoya, Megan Wisniewski, Justin L. Goodsell, Alexander Angerhofer   +3 more
doaj   +2 more sources

Laser Pulses for Studying Photoactive Spin Centers with EPR [PDF]

Micromachines
Quantum technologies are currently being explored for various applications, including computing, secure communication, and sensor technology. A critical aspect of achieving high-fidelity spin manipulations in quantum devices is the controlled optical ...
George Mamin, Ekaterina Dmitrieva, Fadis Murzakhanov, Margarita Sadovnikova, Sergey Nagalyuk, Marat Gafurov   +5 more
doaj   +2 more sources

Flavoproteins as native and genetically encoded spin probes for in cell ESR spectroscopy [PDF]

Nature Communications
Flavin cofactors are attractive Electron Spin Resonance (ESR) probes for proteins because cellular reductants and light can generate their semiquinone states.
Timothée Chauviré, Siddarth Chandrasekaran, Robert Dunleavy, Jack H. Freed, Brian R. Crane   +4 more
doaj   +2 more sources

High FOXA1 levels induce ER transcriptional reprogramming, a pro-metastatic secretome, and metastasis in endocrine-resistant breast cancer

Cell Reports, 2023
Summary: Aberrant activation of the forkhead protein FOXA1 is observed in advanced hormone-related cancers. However, the key mediators of high FOXA1 signaling remain elusive.
Xiaoyong Fu, Resel Pereira, Chia-Chia Liu, Carmine De Angelis, Martin J. Shea, Sarmistha Nanda, Lanfang Qin, Tamika Mitchell, Maria L. Cataldo, Jamunarani Veeraraghavan, Vidyalakshmi Sethunath, Mario Giuliano, Carolina Gutierrez, Balázs Győrffy, Meghana V. Trivedi, Ofir Cohen, Nikhil Wagle, Agostina Nardone, Rinath Jeselsohn, Mothaffar F. Rimawi, C. Kent Osborne, Rachel Schiff   +21 more
doaj   +1 more source

An Algorithmic Approach for the MIS Repair of Ventral Midline Hernias Associated With Diastasis of the Rectus Abdominis Muscle

Journal of Abdominal Wall Surgery, 2022
Purpose: We present our algorithmic approach for symptomatic ventral hernias with Diastasis of the Rectus Abdominis Muscle (DRAM).Methods: Retrospective analysis of patients with symptomatic ventral hernias and DRAM undergoing hernia repair and plication
Cosman Camilo Mandujano, Diego L. Lima, Jason Xia, Prashanth Sreeramoju, Flavio Malcher   +4 more
doaj   +1 more source

A Proton ENDOR Study of Azurin [PDF]

Applied Magnetic Resonance, 2009
As part of our ongoing project that aims at the optimum characterization of the electronic structure of the blue-copper site of azurin from Pseudomonas aeruginosa, we present the complete hyperfine tensors of the protons bound to the Cbeta atom of the copper-bound cysteine 112.
Sottini, S., Gast, P., Blok, A., Canters, G.W., Cavazzini, D., Rossi, G., Groenen, E.J.J.   +6 more
openaire   +3 more sources