Results 131 to 140 of about 5,201 (300)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Low-barrier hydrogen bond powers long-range radical transfer in the metal-free ribonucleotide reductase. [PDF]

Proc Natl Acad Sci U S A
Sirohiwal A, John J, Kutin Y, Kumar R, Baserga F, Srinivas V, Lebrette H, Pöverlein MC, Gamiz-Hernandez AP, Heberle J, Kasanmascheff M, Högbom M, Kaila VRI.   +12 more
europepmc   +2 more sources

35 GHz CW and pulsed ENDOR spectroscopy of a novel diiron imide-hydride complex [PDF]

, 2007
A recently synthesized diiron imide-hydride complex L_3Fe^(III)(μ-NH)(μ-H)Fe^(II)L_3 is of interest for its similarity to a nitrogenase intermediate suggested to contain a bridging hydride.
Hoffman, Brian M., Kinney, R. Adam, Peters, Jonas C., Saouma, Caroline   +3 more
core  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

High-field EPR and ENDOR studies of protein active sites [PDF]

, 2007
In the first part of the present work (Chapter 3), EPR spectroscopy at different microwave frequencies, namely at 9 GHz (X-band), 34 GHz (Q-band) and 180 GHz (G-band), was employed to resolve the g-values and the HFCs of a putative radical intermediate ...
Hertel, Melanie M.
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Cw-endor investigation of metal-ligand interactions in solution. [PDF]

Electron Nuclear DOuble Resonance (ENDOR) spectroscopy has been employed in this Thesis to study a range of paramagnetic metal-ligand complex systems. The investigations focussed on the observation of conformational changes, solvatochromic effects and ...
Tucker, Richard James
core  

ESPECTRO ENDOR DE ^155Gd^3+: ThO_2 [PDF]

, 1973
El método espectroscópico de Resonancia Doble Nuclear Electrónica (ENDOR), desarrollado por G. Feher (1959), es una de las técnicas más importantes para el estudio de Interacciones Hiperfinas.
Fainstein, Carlos
core