Results 111 to 120 of about 5,793 (291)

An ENDOR study of methyl dynamics at low temperature

, 1992
We have studied the motion of the methyl group in the free radical obtained by gamma-irradiation of 4-methyl-2,6-di-t-butylphenol. The ENDOR spectra have been measured in thetemperature range 6 to 200 K. The height of hindering potential barrier has been
MANIERO, ANNA LISA, A. L. Maniero, F. Bonon, U. Segre, BRUSTOLON, MARINA ROSA, M. Brustolon   +5 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Advancement of ENDOR Spectroscopy

Journal of the Spectroscopical Society of Japan, 2006
ENDOR spectroscopy is a powerful technique to investigate the molecular structure. Since the first discovery, a lot of experiments have been performed. In this report, recent advancements of the CW-and pulsed-ENDOR, TRIPLE, and ELDOR techniques were reviewed with our results.
openaire   +2 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

COMPARATIVE COMPUTATIONAL CHARACTERIZATION OF FERRIC CYTOCHROME P450 AND SUPEROXIDE REDUCTASE BINDING TO CYANIDE

Studia Universitatis Babes-Bolyai Chemia, 2016
The active sites of the enzymes superoxide reductase (SOR) and cytochrome P450 feature square pyramidal FeN4S centers, with a thiolate in axial position trans to the substrate binding site but with differing equatorial nitrogenous ligands.
Radu SILAGHI-DUMITRESCU, Daniela CIOLOBOC   +1 more
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Analysis of a Cu‐Doped Metal–Organic Framework, MFM‐520(Zn1‐xCux), for NO2 Adsorption

Advanced Science
MFM‐520(Zn) confines dimers of NO2 with a high adsorption of 4.52 mmol g−1 at 1 bar at 298 K. The synthesis and the incommensurate structure of Cu‐doped MFM‐520(Zn) are reported.
Zi Wang, Alena M. Sheveleva, Jiangnan Li, Zhengyang Zhou, Sergei Sapchenko, George Whitehead, Mark R. Warren, David Collison, Junliang Sun, Martin Schröder, Eric J. L. McInnes, Sihai Yang, Floriana Tuna   +12 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Exomoons and Exorings with the Habitable Worlds Observatory. II. Finding “Endor” with Lunar Eclipses

The Astronomical Journal
Giant planets in the habitable zone may host exomoons with conditions conducive to life. In this paper, we describe a method by which the Habitable Worlds Observatory (HWO) could detect such moons: broadband reflected-light lunar eclipses (e.g., the moon
Mary Anne Limbach, Beck Dacus, Brooke Kotten, Elizabeth Lane, Jacob Lustig-Yaeger, Ryan MacDonald, Tyler D. Robinson, Jean-Baptiste Ruffio, Andrew Vanderburg   +8 more
doaj   +1 more source