Results 101 to 110 of about 5,197 (301)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

COMPARATIVE COMPUTATIONAL CHARACTERIZATION OF FERRIC CYTOCHROME P450 AND SUPEROXIDE REDUCTASE BINDING TO CYANIDE

Studia Universitatis Babes-Bolyai Chemia, 2016
The active sites of the enzymes superoxide reductase (SOR) and cytochrome P450 feature square pyramidal FeN4S centers, with a thiolate in axial position trans to the substrate binding site but with differing equatorial nitrogenous ligands.
Radu SILAGHI-DUMITRESCU, Daniela CIOLOBOC   +1 more
doaj  

Endor and Epr studies of organic radicals in solution

, 1974
The construction and operation of a high power liquid phase Electron Nuclear Double Resonance (ENDOR) spectrometer is described in detail. The several modifications of existing methods that make this spectrometer unique are emphasized, particularly the ...
Kennedy, David Edward Bertram
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Analysis of a Cu‐Doped Metal–Organic Framework, MFM‐520(Zn1‐xCux), for NO2 Adsorption

Advanced Science
MFM‐520(Zn) confines dimers of NO2 with a high adsorption of 4.52 mmol g−1 at 1 bar at 298 K. The synthesis and the incommensurate structure of Cu‐doped MFM‐520(Zn) are reported.
Zi Wang, Alena M. Sheveleva, Jiangnan Li, Zhengyang Zhou, Sergei Sapchenko, George Whitehead, Mark R. Warren, David Collison, Junliang Sun, Martin Schröder, Eric J. L. McInnes, Sihai Yang, Floriana Tuna   +12 more
doaj   +1 more source

A cw-ENDOR investigation of metal-ligand interactions in solution [PDF]

, 2005
Electron Nuclear DOuble Resonance (ENDOR) spectroscopy has been employed in this Thesis to study a range of paramagnetic metal-ligand complex systems. The investigations focussed on the observation of conformational changes, solvatochromic effects and ...
Tucker, Richard James
core  

Principles and Applications of ENDOR Spectroscopy for Structure Determination in Solution and Disordered Matrices

, 2006
Both electron paramagnetic resonance (EPR) and electron nuclear double resonance (ENDOR) spectroscopies are extremely powerful and versatile methods for the characterisation of paramagnetic systems in biology, chemistry, and physics.
Farley, Robert D., Robert D. Farley, Murphy, Damien Martin, Damien M. Murphy   +3 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Exomoons and Exorings with the Habitable Worlds Observatory. II. Finding “Endor” with Lunar Eclipses

The Astronomical Journal
Giant planets in the habitable zone may host exomoons with conditions conducive to life. In this paper, we describe a method by which the Habitable Worlds Observatory (HWO) could detect such moons: broadband reflected-light lunar eclipses (e.g., the moon
Mary Anne Limbach, Beck Dacus, Brooke Kotten, Elizabeth Lane, Jacob Lustig-Yaeger, Ryan MacDonald, Tyler D. Robinson, Jean-Baptiste Ruffio, Andrew Vanderburg   +8 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source