Results 81 to 90 of about 7,208 (294)

ENDOR study of irradiated tooth enamel [PDF]

, 1999
γ- and x-irradiated tooth enamel has been studied by EPR and ENDOR. Radiation-induced EPR spectrum of tooth enamel was found to be a superposition of signals with dominant contribution determined by CO₂- radicals.
Vorona, I., Okulov, S., Ishchenko, S.
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

ESR and ENDOR in V-Band (III)-ENDOR Mechanism in Rotating Frame-Laboratory Frame- [PDF]

From our ENDOR experiments made on Cr3+ in A1203 in the V-band region it has been conc1uded that 3d electrons of Cr3+ couple with the AP7 nuc1ei through the dipole-dipole interactions which are attributed to the so-called the distant ENDOR. In this paper
山本, 孝光, YAMAMOTO, Takamitsu, 八木, 寿郎, INOUE, Masashi, TATSUKAWA, Toshiaki, 井上, 正, 立川, 敏明, YAGI, Hisao   +7 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

endoR computation time scales substantially better than SHAP when applied to random forest classifiers.

, 2022
A-F/ The total CPU time and maximal virtual memory used for three replicate processing runs of the same RF model. The artificial phenotype presented in Fig 2 was used with 18 variables and 1000 samples (see Methods), and endoR was run on B = 1 bootstrap ...
Nicholas D. Youngblut (4732542), Niklas Pfister (5522843), Ruth E. Ley (9233814), Albane Ruaud (14259687)   +3 more
core   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Endor and Epr studies of organic radicals in solution

, 1974
The construction and operation of a high power liquid phase Electron Nuclear Double Resonance (ENDOR) spectrometer is described in detail. The several modifications of existing methods that make this spectrometer unique are emphasized, particularly the ...
Kennedy, David Edward Bertram
core   +1 more source

13C- and proton-ENDOR studies of 13C-labelled organic radicals

, 1978
As part of a systematic non-proton ENDOR-in-solution study results are reported for 13C in several isotopically enriched model compounds. Methods for synthesizing these labelled compounds are also presented.
Biehl, R., Lubitz, W., Plato, M., Zimmermann, H., Möbius, K., Fey, H.   +5 more
core   +1 more source