Results 111 to 120 of about 9,566 (262)

Structural basis for human mitochondrial tRNA maturation

Nature Communications
The human mitochondrial genome is transcribed into two RNAs, containing mRNAs, rRNAs and tRNAs, all dedicated to produce essential proteins of the respiratory chain. The precise excision of tRNAs by the mitochondrial endoribonucleases (mt-RNase), P and Z,
Vincent Meynier, Steven W. Hardwick, Marjorie Catala, Johann J. Roske, Stephanie Oerum, Dimitri Y. Chirgadze, Pierre Barraud, Wyatt W. Yue, Ben F. Luisi, Carine Tisné   +9 more
doaj   +1 more source

Degradation of RNA in bacteria: comparison of mRNA and stable RNA [PDF]

, 2006
Degradation of RNA plays a central role in RNA metabolism. In recent years, our knowledge of the mechanisms of RNA degradation has increased considerably with discovery of the participating RNases and analysis of mutants affected in the various ...
Deutscher, Murray P.
core   +2 more sources

Identification, validation, and characterization of approved and investigational drugs interfering with the SARS‐CoV‐2 endoribonuclease Nsp15

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Since the emergence of SARS‐CoV‐2 at the end of 2019, the virus has caused significant global health and economic disruptions. Despite the rapid development of antiviral vaccines and some approved treatments such as remdesivir and paxlovid, effective antiviral pharmacological treatments for COVID‐19 patients remain limited. This study explores
Spyros D. Chatziefthymiou, Maria Kuzikov, Sara Afandi, Greta Kovacs, Sukrit Srivastava, Andrea Zaliani, Andrey Gruzinov, Guillaume Pompidor, Michele Lunelli, Golam Rizvee Ahmed, Jörg Labahn, Johanna Hakanpää, Björn Windshügel, Michael Kolbe   +13 more
wiley   +1 more source

VapCs of Mycobacterium tuberculosis cleave RNAs essential for translation

Nucleic Acids Research, 2016
The major human pathogen Mycobacterium tuberculosis can survive in the host organism for decades without causing symptoms. A large cohort of Toxin–Antitoxin (TA) modules contribute to this persistence.
K. Winther, J. Tree, D. Tollervey, K. Gerdes   +3 more
semanticscholar   +1 more source

Phylogenetic Analysis of the Endoribonuclease Dicer Family

PLoS ONE, 2014
Dicers are proteins of the ribonuclease III family with the ability to process dsRNA, involved in regulation of gene expression at the post-transcriptional level. Dicers are conserved from basal metazoans to higher metazoans and contain a number of functional domains that interact with dsRNA.
Zeqian Gao, Miao Wang, David Blair, Yadong Zheng, Yongxi Dou   +4 more
openaire   +6 more sources

RNA Viruses: RNA Roles in Pathogenesis, Coreplication and Viral Load. [PDF]

, 2015
The review intends to present and recapitulate the current knowledge on the roles and importance of regulatory RNAs, such as microRNAs and small interfering RNAs, RNA binding proteins and enzymes processing RNAs or activated by RNAs, in cells infected by
Massimo Mallardo,, Poltronieri, Palmiro, Sun, Binlian   +2 more
core   +1 more source

Nimbolide Targeting SIRT1 Protects Against Acetaminophen‐Induced Acute Liver Injury by Regulating Oxidative Stress and Endoplasmic Reticulum Stress

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Acetaminophen (APAP) is a major cause of acute liver injury (ALI), and N‐acetylcysteine is the only approved detoxification drug. Nimbolide (Nim), which is isolated from the neem tree (Azadirachta indica), possesses protective properties against multiple diseases, including pancreatitis, autoimmune hepatitis, arthritis, and diabetic ...
Junhui Ba, Yunsen Lin, Jingcong Zhang, Yanhong Wang, Benquan Wu   +4 more
wiley   +1 more source

DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors

Journal of Cell Science, 2016
The DNA damage response (DDR) plays a central role in preserving genome integrity. Recently, we reported that the endoribonucleases DICER and DROSHA contribute to DDR activation by generating small non-coding RNAs, termed DNA damage response RNA (DDRNA),
S. Francia, Matteo Cabrini, Valentina Matti, A. Oldani, F. d’Adda di Fagagna   +4 more
semanticscholar   +1 more source

Transcriptional cross-activation between toxin-antitoxin systems of Escherichia coli [PDF]

, 2013
BACKGROUND: Bacterial toxin-antitoxin (TA) systems are formed by potent regulatory or suicide factors (toxins) and their short-lived inhibitors (antitoxins). Antitoxins are DNA-binding proteins and auto-repress transcription of TA operons.
Niilo Kaldalu, Tanel Tenson, Toomas Mets, Villu Kasari   +3 more
core   +1 more source

Circulating genomic biomarkers predict chemoradiotherapy resistance and immunotherapy response in locally advanced non‐small‐cell lung cancer

VIEW, Volume 6, Issue 3, June 2025.
The insufficient sensitivity of single circulating tumor DNA (ctDNA)‐molecular residual disease (MRD) prediction remains unresolved and hinders the clinical implementation of ctDNA. Through prospective cohort study, independent validations, and mechanism exploration from peripheral blood and tumor tissue, we demonstrate that ctDNA‐based STK11/KEAP1 ...
Yu Wang, Canjun Li, Tao Zhang, Jianyang Wang, Wenyang Liu, Lei Deng, Ying Jiang, Jinghao Duan, Luhua Wang, Hong Ge, Nan Bi   +10 more
wiley   +1 more source