Potential Use of Folate-polyethylene glycol (PEG)-Appended Dendrimer (G3) Conjugate with alpha-Cyclodextrin as DNA Carriers to Tumor Cells [PDF]
, 2011 We previously reported that polyamidoamine STARBURST dendrimer (generation 3, G3) (dendrimer) conjugate with alpha-cyclodextrin (alpha-CyD) having an average degree of substitution of 2.4 of alpha-CyD (alpha-CDE) provided remarkable aspects as novel ...
Ayumi Yoshimitsu +9 more
core +1 more source
Genetic reconstitution of the human Adenovirus type 2 temperature-sensitive 1 mutant defective in endosomal escape [PDF]
, 2009 Nicola Imelli +4 more
openalex +1 more source
Mucin Glycoprotein Nanoparticles Enable a Selective Antisense Therapy for Oncogenic MicroRNAs
Advanced NanoBiomed Research, EarlyView.Mucin glycoproteins are turned into nanoparticles by employing synthetic DNA strands, which have a dual function: they stabilize the nanoparticles and act as binding sites for intracellular miRNA‐21. Thus, upon internalization into tumor cells, these mucin nanoparticles can deplete miRNA‐21 from the cytosol, which induces apoptosis in vitro and in vivo.
Ceren Kimna +9 more
wiley +1 more source
Escaping to silence using an endosome-disrupting polymer
Molecular Therapy, 2021 Jamie L, Betker +2 more
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Immune-Complexed Adenovirus Induce AIM2-Mediated Pyroptosis in Human Dendritic Cells.
PLoS Pathogens, 2016 Human adenoviruses (HAdVs) are nonenveloped proteinaceous particles containing a linear double-stranded DNA genome. HAdVs cause a spectrum of pathologies in all populations regardless of health standards. Following repeat exposure to multiple HAdV types,
Karsten Eichholz +9 more
doaj +1 more source
Bioreducible and acid-labile poly(amido amine)s for efficient gene delivery
International Journal of Nanomedicine, 2012 Zhi-Qiang Yu,1 Jun-Jie Yan,1 Ye-Zi You,1,* Qing-Hui Zhou2,*1Chinese Academy of Sciences, Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui, People’
Zhou QH, You YZ, Yan JJ, Yu ZQ
doaj
Efficient cell delivery mediated by lipid‐specific endosomal escape of supercharged branched peptides [PDF]
, 2018 Dakota J. Brock +9 more
openalex +1 more source
BMEMat, EarlyView.Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen +7 more
wiley +1 more source
Understanding the mechanism of Adenovirus endosomal escape
, 2021 Adenoviruses (AdV) are non-enveloped dsDNA viruses that cause respiratory and gastrointestinal diseases and are commonly used as vaccine and gene therapy vectors. In order to replicate inside a host cell, AdV must first penetrate the endosomal membrane and gain access to the cytosol. A highly conserved amphiphilic alpha helix within AdV protein VI (pVI)
openaire +1 more source
Stochastic model of endosomal escape of Influenza virus
, 2015 22 pages, 3 figures, 2 ...
Lagache, Thibault +4 more
openaire +2 more sources