Results 181 to 190 of about 47,261 (313)

Receptor-mediated gene transfer to airway epithelial cells in primary culture [PDF]

, 1993
Agarwal, Santosh, Curiel, David T., Harris, C. E., Hu, P.-C., Wagner, Ernst   +4 more
core   +1 more source

Illuminating endosomal escape of polymorphic lipid nanoparticles that boost mRNA delivery

, 2021
Marco Herrera‐Barrera, Jeonghwan Kim, Yulia Eygeris, Antony Jozić, Gaurav Sahay   +4 more
openalex   +2 more sources

FAST‐CRISPR: Fusogenic Association and Secured Transfection of CRISPR/Cas9 Ribonucleoproteins Using Lipid‐Silica Hybrid Nanoparticles for Therapeutic Genome Editing

Small, EarlyView.
FAST‐CRISPR nanoparticles combine fusogenic lipids and tailored porous silica for rapid and direct cytosolic delivery of CRISPR/Cas9 ribonucleoproteins, bypassing endocytosis. This approach achieves highly efficient genome editing, selectively induces cancer cell apoptosis through multiplex DNA targeting, and effectively suppresses tumor growth in vivo,
Minjong Kim, Kyunghwan Kim, Jihyun Lee, Soyoung Lee, Subin Choi, Soo Ah Park, Euihwan Jeong, Song‐Yi Choi, Hee Ho Park, Tae‐Eun Park, Taejoon Kwon, Kyungjae Myung, Jounghyun Yoo, Seung Woo Cho, Jinmyoung Joo   +14 more
wiley   +1 more source

Single‐Particle Characterization Reveals Heterogeneous Extracellular Vesicle Fusion with Liposomes

Small Methods, EarlyView.
This study used five orthogonal single‐particle techniques to compare how common mechanical methods fuse extracellular vesicles with liposomes. By quantifying fused‐particle yield, purity, and vesicle integrity, we found that freeze‐thaw and sonication generated the highest fusion but that all methods introduced membrane perturbation or damage.
Rachel R. Mizenko, Vishalakshi Arun, David Meshkanian, Neona M. Lowe, Henna Mohabbat, Aijun Wang, Randy P. Carney   +6 more
wiley   +1 more source

A Poly (β‐Amino Esters)‐Based Multicomponent Nanoparticle for Efficient mRNA Delivery to Acute Myeloid Leukemia Cells

ChemistryEurope
Gene delivery to acute myeloid leukemia (AML) cells is crucial for mechanistic studies and targeted therapeutics, yet nonviral transfection methods remain limited by low cellular uptake and inefficient endosomal escape in suspension AML cells.
Zheng Wang, Dehua Huang, Lanrong Wu, Yuheng Cao, Yejun Zhang, Chunyan Li, Jiang Jiang, Guangcun Chen, Qiangbin Wang   +8 more
doaj   +1 more source

Antibody h-R3-dendrimer mediated siRNA has excellent endosomal escape and tumor targeted delivery ability, and represents efficient siPLK1 silencing and inhibition of cell proliferation, migration and invasion

, 2016
Jun Li, Jing Liu, Shengnan Li, Yanli Hao, Lei Chen, Xiaoning Zhang   +5 more
openalex   +2 more sources

Protein Corona Inhibits Endosomal Escape of Functionalized DNA Nanostructures in Living Cells

, 2021
Barbora Smolková, T. MacCulloch, Tyler F. Rockwood, Minghui Liu, Skylar J.W. Henry, Adam Frtús, Mariia Uzhytchak, Mariia Lunová, Martin Hof, Piotr Jurkiewicz, A. Dejneka, Nicholas Stephanopoulos, Oleg Lunov   +12 more
openalex   +2 more sources

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Synergistic antiviral activity against human adenovirus through combination of itraconazole and brincidofovir

British Journal of Pharmacology, EarlyView.
Background and Purpose Human adenovirus (HAdV) causes respiratory or gastrointestinal tract infections depending on the virus subtype. While HAdV infections are generally self‐limiting in immunocompetent people, they can result in significant morbidity and mortality in immunocompromised adults and children.
Mohamed Zamzamy, Sophie Post, Wing Hang Ip, Elin Hahlin, Sebastian Kühn, Andrea Pirosu, Christian Conze, Martin Baumdick, Hamburg Intestinal Study Group, Madeleine J. Bunders, Britta F. Zecher, Angelique Hoelzemer, Stephan Linder, Niklas Arnberg, Thomas Dobner, Marcus Altfeld, Sebastian Schloer   +16 more
wiley   +1 more source

Therapeutic Strategies to Overcome Payload Resistance of Trastuzumab Deruxtecan in HER2‐Positive Cancers

Cancer Science, EarlyView.
Overexpression of ABC transporters, especially ABCG2 and ABCB1, mediates acquired resistance to T‐DXd in HER2‐positive cancers. Inhibition of these transporters restored T‐DXd efficacy, highlighting efflux‐mediated resistance as a potential therapeutic target. ABSTRACT Antibody–drug conjugates (ADCs) are emerging as a promising class of targeted cancer
Yuya Murase, Shigeki Nanjo, Sachiko Arai, Sota Kondo, Hayato Koba, Yifeng Liu, Koji Fukuda, Shigeki Sato, Jun Kinoshita, Noriyuki Inaki, Tsukasa Ueda, Shunichi Nomura, Yuichi Tambo, Takahiro Shimizu, Masafumi Horie, Daichi Maeda, Richard W. Wong, Kazuyoshi Hosomichi, Takafumi Kobayashi, Satoshi Watanabe, Kenta Yamamura, Noriyuki Ohkura, Miki Abo, Seiji Yano   +23 more
wiley   +1 more source