Results 201 to 210 of about 47,261 (313)
Endosomal escape of RNA therapeutics
RNA therapeutics is a new class of targeted therapies that has entered the clinic in the last decade. Lipid nanoparticles (LNPs) and conjugation to N-acetylgalactosamine have proven to be efficient strategies to deliver RNA payload to the liver. Successful delivery of sensitive RNA molecules to other target tissues or tumors remains one of the key ...
openaire +1 more source
RNA‐Based Therapies for Inherited Metabolic Disorders
Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.ABSTRACT Inherited metabolic disorders (IMDs) are a diverse and complex group of genetic conditions resulting from deficiencies in enzymes, transporters, or cofactors. These deficiencies lead to metabolic dysfunction and severe clinical consequences. Despite significant progress in understanding their molecular basis, treatment options remain limited ...
Reddy Sreekanth Vootukuri +5 more
wiley +1 more source
MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.The review provides a comprehensive analysis of microbiome‐mediated oncogenic mechanisms in various cancers, emphasizing the unique therapeutic strategies facilitated by nanotechnology. It aims to fill this gap by systematically reviewing nanotechnology‐driven strategies for microbiome elimination, with a focus on their ability to improve the cold TME ...
Yumei Gan, Yan Zhang, Xia Dong, Feng Lv
wiley +1 more source
Plasma membrane depolarization reveals endosomal escape incapacity of cell-penetrating peptides.
European journal of pharmaceutics and biopharmaceutics, 2023 Marc Serulla +6 more
semanticscholar +1 more source
Escaping alveolar macrophage endosomal retention explains massive expansion of SARS-CoV-2 delta variant [PDF]
, 2021 Zhenfeng Wang +10 more
openalex +1 more source
The X Factor in Immunity: Sex Differences Shaped by the X Chromosome
Immunological Reviews, Volume 338, Issue 1, March 2026.ABSTRACT There are sex differences with immune responses where females exhibit stronger immune responses compared to males. Both sex hormones and sex chromosome differences between males and females contribute to the observed sex differences with innate and adaptive immune cell composition and function.
Katherine B. Radovanovic +2 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 6, 2 February 2026.Nanoparticle‐based tolerogenic vaccines harness controlled antigen delivery and immunomodulation to establish tolerance in autoimmunity and allergy. This review outlines how nanoparticle design (size, shape, composition, administration route) influences biodistribution and immune‐cell targeting.
Benjamin E. Nachod +3 more
wiley +2 more sources
ChemMedChem, Volume 21, Issue 3, 12 February 2026.β‐cyclodextrin‐based multicharged polymers—linear or cross‐linked—enhance the delivery of mitogen‐activated protein kinase inhibitors (selumetinib, trametinib) in glioblastoma cells. These carriers enhance the antiproliferative effect of the drugs and strengthen extracellular signal‐regulated kinase pathway inhibition.
Noemi Bognanni +6 more
wiley +1 more source
The Biology of Endosomal Escape: Strategies for Enhanced Delivery of Therapeutics. [PDF]
ACS NanoChahal GS +3 more
europepmc +1 more source