Results 291 to 300 of about 47,261 (313)

Liposomal Targeting Modifies Endosomal Escape: Design and Mechanistic Implications

ACS Biomaterials Science & Engineering, 2022
Development of effective targeted nanoparticle (TNP) therapeutics requires rational design of targeted and endosomolytic moieties. Nevertheless, endosomal escape of TNPs is poorly understood, relying on extrapolation of knowledge from nontargeted (NP) systems.
Franklin Mejia, Sabrina Khan, Basar Bilgicer   +2 more
openaire   +2 more sources

Advancing endosomal escape of polymeric nanoparticles: towards improved intracellular delivery.

Materials Horizons
Polymeric nanoparticles have emerged as a promising platform for the intracellular delivery of therapeutics, offering unique advantages such as tunable chemical properties and stimuli-responsive behavior.
Yufu Wang, Vajini Ukwattage, Yijun Xiong, Georgina K Such   +3 more
semanticscholar   +1 more source

The Interplay of Endosomal Escape and RNA Release from Polymeric Nanoparticles.

Langmuir
Ribonucleic acid (RNA) nanocarriers, specifically lipid nanoparticles and polymeric nanoparticles, enable RNA transfection both in vitro and in vivo; however, only a small percentage of RNA endocytosed by a cell is delivered to the cytosolic machinery ...
Timothy H. Cheung, M. Shoichet
semanticscholar   +1 more source

Effective mRNA Protection by Poly(L-Ornithine) Synergizes with Endosomal Escape Functionality of a Charge-Conversion Polymer Toward Maximizing mRNA Introduction Efficiency.

Macromolecular rapid communications, 2022
For efficient delivery of messenger (m)RNA, delivery carriers need two major functions: protecting mRNA from nucleases and translocating mRNA from endolysosomes to the cytoplasm.
A. Dirisala, S. Uchida, Junjie Li, Joachim F R Van Guyse, Kotaro Hayashi, S. V. Vummaleti, Sarandeep Kaur, Y. Mochida, S. Fukushima, K. Kataoka   +9 more
semanticscholar   +1 more source

Core Role of Hydrophobic Core of Polymeric Nanomicelle in Endosomal Escape of siRNA.

Nano letters (Print), 2021
Efficient endosomal escape is the most essential but challenging issue for siRNA drug development. Herein, a series of quaternary ammonium-based amphiphilic triblock polymers harnessing an elaborately tailored pH-sensitive hydrophobic core were ...
Chunhui Li, Junhui Zhou, Yidi Wu, Yanliang Dong, Lili Du, Tongren Yang, Yongheng Wang, Shuai Guo, Mengjie Zhang, A. Hussain, Haihua Xiao, Yuhua Weng, Yong Huang, Xiaoxia Wang, Zicai Liang, H. Cao, Yongxiang Zhao, Xing-jie Liang, Anjie Dong, Yuanyu Huang   +19 more
semanticscholar   +1 more source

Recent Progress in the Endosomal Escape Mechanism and Chemical Structures of Polycations for Nucleic Acid Delivery.

Macromolecular Bioscience
Nucleic acid-based therapies are seeing a spiralling surge. Stimuli-responsive polymers, especially pH-responsive ones, are gaining widespread attention because of their ability to efficiently deliver nucleic acids.
Mohit J Mehta, Hyun Jin Kim, Sung Been Lim, Mitsuru Naito, K. Miyata   +4 more
semanticscholar   +1 more source

Design, Synthesis, and Biochemical Analysis of a Molecule Designed to Enhance Endosomal Escape

AAPS Journal, 2023
RNA therapeutics, including siRNAs, ASOs, and PMOs, have great potential to treat human disease. However, RNA therapeutics are too large, too charged, and/or too hydrophilic to cross the cellular membrane and are instead taken up into cells by ...
Satish G. Jadhav, Ryan L Setten, Carlos Medina, Xian-Shu Cui, Steven F. Dowdy   +4 more
semanticscholar   +1 more source

Overcoming Endosomal Escape Barriers in Gene Drug Delivery Using De Novo Designed pH-Responsive Peptides.

ACS Nano
A major challenge in using nanocarriers for intracellular drug delivery is their restricted capacity to escape from endosomes into the cytosol. Here, we significantly enhance the drug delivery efficiency by accurately predicting and regulating the ...
Zixuan Wang, Jiaxing Zhang, Yuefei Wang, Jialin Zhou, Xinhao Jiao, Mingshan Han, Xuelin Zhang, Hailiang Hu, R. Su, Yumiao Zhang, Wei Qi   +10 more
semanticscholar   +1 more source

Endosomal Escape of Polymer‐Coated Silica Nanoparticles in Endothelial Cells

Small, 2020
AbstractCurrent investigations into hazardous nanoparticles (i.e., nanotoxicology) aim to understand the working mechanisms that drive toxicity. This understanding has been used to predict the biological impact of the nanocarriers as a function of their synthesis, material composition, and physicochemical characteristics. It is particularly critical to
Alessandro Parodi, Michael Evangelopoulos, Noemi Arrighetti, Armando Cevenini, Megan Livingston, Sm Z. Khaled, Brandon S. Brown, Iman K. Yazdi, Francesca Paradiso, Jocelyn N. Campa‐Carranza, Alessandro De Vita, Francesca Taraballi, Ennio Tasciotti   +12 more
openaire   +3 more sources

Enhanced Endosomal Escape by Light-Fueled Liquid-Metal Transformer

Nano Letters, 2017
Effective endosomal escape remains as the "holy grail" for endocytosis-based intracellular drug delivery. To date, most of the endosomal escape strategies rely on small molecules, cationic polymers, or pore-forming proteins, which are often limited by the systemic toxicity and lack of specificity.
Yue Lu, Yiliang Lin, Zhaowei Chen, Quanyin Hu, Yang Liu, Shuangjiang Yu, Wei Gao, Michael D. Dickey, Zhen Gu   +8 more
openaire   +2 more sources