Results 271 to 280 of about 399,723 (294)

Overcoming Endosomal Escape Barriers in Gene Drug Delivery Using De Novo Designed pH-Responsive Peptides.

ACS Nano
A major challenge in using nanocarriers for intracellular drug delivery is their restricted capacity to escape from endosomes into the cytosol. Here, we significantly enhance the drug delivery efficiency by accurately predicting and regulating the ...
Zixuan Wang, Jiaxing Zhang, Yuefei Wang, Jialin Zhou, Xinhao Jiao, Mingshan Han, Xuelin Zhang, Hailiang Hu, R. Su, Yumiao Zhang, Wei Qi   +10 more
semanticscholar   +1 more source

Endosomal Escape of Polymer‐Coated Silica Nanoparticles in Endothelial Cells

Small, 2020
AbstractCurrent investigations into hazardous nanoparticles (i.e., nanotoxicology) aim to understand the working mechanisms that drive toxicity. This understanding has been used to predict the biological impact of the nanocarriers as a function of their synthesis, material composition, and physicochemical characteristics. It is particularly critical to
Alessandro Parodi, Michael Evangelopoulos, Noemi Arrighetti, Armando Cevenini, Megan Livingston, Sm Z. Khaled, Brandon S. Brown, Iman K. Yazdi, Francesca Paradiso, Jocelyn N. Campa‐Carranza, Alessandro De Vita, Francesca Taraballi, Ennio Tasciotti   +12 more
openaire   +3 more sources

Recent Progress in the Endosomal Escape Mechanism and Chemical Structures of Polycations for Nucleic Acid Delivery.

Macromolecular Bioscience
Nucleic acid-based therapies are seeing a spiralling surge. Stimuli-responsive polymers, especially pH-responsive ones, are gaining widespread attention because of their ability to efficiently deliver nucleic acids.
Mohit J Mehta, Hyun Jin Kim, Sung Been Lim, Mitsuru Naito, K. Miyata   +4 more
semanticscholar   +1 more source

Imidazolyl Lipids Enhanced LNP Endosomal Escape for Ferroptosis RNAi Treatment of Cancer.

Small
Treatments for cancer that incorporate small interfering RNA (siRNA) to target iron-dependent ferroptosis are thought to be highly promising. However, creating a reliable and clinically feasible siRNA delivery system continues to be a major obstacle in ...
Yuanyuan Liu, Fengyang He, Longming Chen, Yahan Zhang, Han Zhang, Junhai Xiao, Qingbin Meng   +6 more
semanticscholar   +1 more source

Cell-Penetrating Peptides as Keys to Endosomal Escape and Intracellular Trafficking in Nanomedicine Delivery.

Current Medicinal Chemistry
This review article discusses the challenges of delivering cargoes to the cytoplasm, for example, proteins, peptides, and nucleic acids, and the mechanisms involved in endosomal escape.
Sakshi Soni, S. K. Kori, Priyanshu Nema, Arun K. Iyer, Vandana Soni, S. Kashaw   +5 more
semanticscholar   +1 more source

Tracking the Endosomal Escape of Nanoparticles in Live Cells Using a Triplex‐Forming Oligonucleotide

Advanced Functional Materials
Nanoparticle‐mediated intracellular delivery of oligonucleotides is a complex phenomenon that depends on the architecture and the intracellular trafficking of the engineered nanoparticles. Unravelling the molecular arrangements of oligonucleotides within
S. K. Bhangu, Liviana Mummolo, S. Fernandes, A. Amodio, Agata Radziwon, Brendan P. Dyett, Marco Savioli, Nitin Mantri, Christina Cortez‐Jugo, Frank Caruso, Francesca Cavalieri   +10 more
semanticscholar   +1 more source

Beyond chloroquine: Cationic amphiphilic drugs as endosomal escape enhancers for nucleic acid therapeutics.

Current Opinion in Chemical Biology
Nucleic acid (NA) therapeutics have the potential to treat or prevent a myriad of diseases but generally require cytosolic delivery to be functional. NA drugs are therefore often encapsulated into delivery systems that mediate effective endocytic uptake ...
Aliona Debisschop, Bram Bogaert, Cristina Muntean, S. D. De Smedt, K. Raemdonck   +4 more
semanticscholar   +1 more source

Enhancing Targeted Drug Delivery through Cell‐Specific Endosomal Escape

ChemMedChem
Endosome is a major barrier in the intracellular delivery of drugs, especially for biologics, such as proteins, peptides, and nucleic acids. After being endocytosed, these cargos will be trapped inside the endosomal compartments and finally degraded in ...
Pengwen Chen, Horacio Cabral
semanticscholar   +1 more source

Enhancing endosomal escape for nanoparticle mediated siRNA delivery

Nanoscale, 2014
Gene therapy with siRNA is a promising biotechnology to treat cancer and other diseases. To realize siRNA-based gene therapy, a safe and efficient delivery method is essential. Nanoparticle mediated siRNA delivery is of great importance to overcome biological barriers for systemic delivery in vivo.
openaire   +2 more sources

Entrapment of lipid nanoparticles in peripheral endosomes but not lysosomes impairs intracellular trafficking and endosomal escape

International Journal of Pharmaceutics
The uptake and intracellular trafficking of lipid nanoparticles (LNPs) along the endolysosomal pathway leading to releasing compartments is critical for delivery efficiency. How the players of the processes interact with each other to affect LNP delivery remains unclear.
Yiqin, Cheng, E, Zhao, Xiaojuan, Yang, Chengzhi, Luo, Guanghui, Zi, Rui, Wang, Yuhong, Xu, Baowei, Peng   +7 more
openaire   +2 more sources