Results 261 to 270 of about 399,723 (294)

siRNA Vehicles for High Endosomal Escapability

2021
Small interfering RNA (siRNA) is a novel therapeutic modality for the treatment of intractable diseases; however, the development of a useful siRNA delivery vector is imperative for clinical use. Since siRNA works in the cytoplasm, the ability of the carrier to escape destruction in the endosomes is a highly required characteristic for the induction of
Hiroyuki, Koide, Sei, Yonezawa, Tomohiro, Asai   +2 more
openaire   +2 more sources

Endosomal Escape: A Bottleneck in Intracellular Delivery

Journal of Nanoscience and Nanotechnology, 2014
With advances in therapeutic science, apart from drugs, newer bioactive moieties like oligonucleotides, proteins, peptides, enzymes and antibodies are constantly being introduced for the betterment of therapeutic efficacy. These moieties have intracellular components of the cells like cytoplasm and nucleus as one of their pharmacological sites for ...
Harshad K, Shete, Rashmi H, Prabhu, Vandana B, Patravale   +2 more
openaire   +2 more sources

Engineered Histidine-Rich Peptides Enhance Endosomal Escape for Antibody-Targeted Intracellular Delivery of Functional Proteins.

Angewandte Chemie, 2023
Currently, the clinical application of protein/peptide therapeutics is mainly limited to the modulation of diseases in extracellular spaces. Intracellular targets are hardly accessed, owing largely to the endosomal entrapment of internalized proteins ...
Yan Zhao, Haolin Jiang, Jiazheng Yu, Luyao Wang, Juanjuan Du   +4 more
semanticscholar   +1 more source

Simultaneous dendritic cells targeting and effective endosomal escape enhance sialic acid-modified mRNA vaccine efficacy and reduce side effects.

Journal of Controlled Release, 2023
mRNA vaccines are attractive prospects for the development of DC-targeted vaccines; however, no clinical success has been realized because, currently, it is difficult to simultaneously achieve DC targeting and efficient endosomal/lysosomal escape. Herein,
Xueying Tang, Jiashuo Zhang, Dezhi Sui, Qiongfen Yang, Tianyu Wang, Zihan Xu, Xiaoya Li, Xin Gao, Xinyang Yan, Xinrong Liu, Yanzhi Song, Yihui Deng   +11 more
semanticscholar   +1 more source

Tannic Acid Lipid Nanoparticles can Deliver Messenger RNA Payloads and Improve their Endosomal Escape

Advances in Therapy, 2023
Even though lipid nanoparticles (LNPs) can deliver messenger RNA (mRNA) payloads into cells, their efficiency is often limited by endosomal trapping which prevents RNA payloads from acting therapeutically.
Yutian Ma, Owen S. Fenton
semanticscholar   +1 more source

Advancing endosomal escape of polymeric nanoparticles: towards improved intracellular delivery.

Materials Horizons
Polymeric nanoparticles have emerged as a promising platform for the intracellular delivery of therapeutics, offering unique advantages such as tunable chemical properties and stimuli-responsive behavior.
Yufu Wang, Vajini Ukwattage, Yijun Xiong, Georgina K Such   +3 more
semanticscholar   +1 more source

The Interplay of Endosomal Escape and RNA Release from Polymeric Nanoparticles.

Langmuir
Ribonucleic acid (RNA) nanocarriers, specifically lipid nanoparticles and polymeric nanoparticles, enable RNA transfection both in vitro and in vivo; however, only a small percentage of RNA endocytosed by a cell is delivered to the cytosolic machinery ...
Timothy H. Cheung, M. Shoichet
semanticscholar   +1 more source

Regulating mRNA endosomal escape through lipid rafts: A review.

International journal of pharmaceutics
Messenger RNA (mRNA) therapeutics, enabled by lipid nanoparticles (LNPs) delivery systems, have revolutionized modern medicine by facilitating the delivery of genetic cargo to target cells.
Xinxing Wang, Xin Shi, Ruifeng Wang
semanticscholar   +1 more source

Effective mRNA Protection by Poly(L-Ornithine) Synergizes with Endosomal Escape Functionality of a Charge-Conversion Polymer Toward Maximizing mRNA Introduction Efficiency.

Macromolecular rapid communications, 2022
For efficient delivery of messenger (m)RNA, delivery carriers need two major functions: protecting mRNA from nucleases and translocating mRNA from endolysosomes to the cytoplasm.
A. Dirisala, S. Uchida, Junjie Li, Joachim F R Van Guyse, Kotaro Hayashi, S. V. Vummaleti, Sarandeep Kaur, Y. Mochida, S. Fukushima, K. Kataoka   +9 more
semanticscholar   +1 more source

Core Role of Hydrophobic Core of Polymeric Nanomicelle in Endosomal Escape of siRNA.

Nano letters (Print), 2021
Efficient endosomal escape is the most essential but challenging issue for siRNA drug development. Herein, a series of quaternary ammonium-based amphiphilic triblock polymers harnessing an elaborately tailored pH-sensitive hydrophobic core were ...
Chunhui Li, Junhui Zhou, Yidi Wu, Yanliang Dong, Lili Du, Tongren Yang, Yongheng Wang, Shuai Guo, Mengjie Zhang, A. Hussain, Haihua Xiao, Yuhua Weng, Yong Huang, Xiaoxia Wang, Zicai Liang, H. Cao, Yongxiang Zhao, Xing-jie Liang, Anjie Dong, Yuanyu Huang   +19 more
semanticscholar   +1 more source