Results 71 to 80 of about 399,723 (294)
Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery
Research, 2023 Nanocarriers have therapeutic potential to facilitate drug delivery, including biological agents, small-molecule drugs, and nucleic acids. However, their efficiency is limited by several factors; among which, endosomal/lysosomal degradation after ...
Chong Qiu +10 more
doaj +1 more source
Breathing Life into Polycations [PDF]
, 2008 The lack of efficient delivery systems is still limiting the full therapeutic potential of siRNA. For the purpose of nucleic acid transfer, among other synthetic carrier systems, polycations have been applied.
Meyer, Martin +4 more
core +1 more source
Journal of Nanobiotechnology, 2022 Nanoparticles have been widely applied as gene carrier for improving RNA interference (RNAi) efficiency in medical and agricultural fields. However, the mechanism and delivery process of nanoparticle-mediated RNAi is not directly visualized and ...
Zhongzheng Ma +7 more
semanticscholar +1 more source
Insights into the kinetics of siRNA-mediated gene silencing from live-cell and live-animal bioluminescent imaging [PDF]
, 2006 Small interfering RNA (siRNA) molecules are potent effectors of post-transcriptional gene silencing. Using noninvasive bioluminescent imaging and a mathematical model of siRNA delivery and function, the effects of target-specific and treatment-specific ...
Bartlett, Derek W., Davis, Mark E.
core +1 more source
Carbohydrate Polymers, 2023 This study aimed to evaluate the effect of thiolated α-cyclodextrin (α-CD-SH) on the cellular uptake of its payload. For this purpose, α-CD was thiolated using phosphorous pentasulfide.
Özlem Kaplan +6 more
semanticscholar +1 more source
A molecular view on the escape of lipoplexed DNA from the endosome
eLife, 2020 The use of non-viral vectors for in vivo gene therapy could drastically increase safety, whilst reducing the cost of preparing the vectors. A promising approach to non-viral vectors makes use of DNA/cationic liposome complexes (lipoplexes) to deliver the genetic material.
Bart MH Bruininks +3 more
openaire +5 more sources
Breaking down the barriers: siRNA delivery and endosome escape [PDF]
Journal of Cell Science, 2010 RNA interference (RNAi)-based technologies offer an attractive strategy for the sequence-specific silencing of disease-causing genes. The application of small interfering (si)RNAs as potential therapeutic agents requires safe and effective methods for their delivery to the cytoplasm of the target cells and tissues. Recent studies have shown significant
Monika, Dominska, Derek M, Dykxhoorn
openaire +2 more sources
Plasma membrane depolarization reveals endosomal escape incapacity of cell-penetrating peptides.
European journal of pharmaceutics and biopharmaceutics, 2023 Cell-penetrating peptides (CPPs) are short (
Marc Serulla +6 more
semanticscholar +1 more source
pH-triggered endosomal escape of pore-forming Listeriolysin O toxin-coated gold nanoparticles
Journal of Nanobiotechnology, 2019 Background A major bottleneck in drug delivery is the breakdown and degradation of the delivery system through the endosomal/lysosomal network of the host cell, hampering the correct delivery of the drug of interest.
Ismael Plaza-GA +8 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2021 DNA/RNA heteroduplex oligonucleotide (HDO), composed of DNA/locked nucleic acid (LNA) antisense oligonucleotide (ASO) and complementary RNA, is a next-generation antisense therapeutic agent.
Daisuke Ono +6 more
doaj +1 more source