Results 51 to 60 of about 399,723 (294)

Membrane trafficking: Retrofusion as an escape route out of the endosome

Current Biology, 2021
Intraluminal vesicles accumulate within the endosomal lumen before lysosomal delivery or extracellular release. A new study reports the development of an elegant assay showing that these vesicles can escape from the endosomal lumen by 'back-fusion' or 'retrofusion' with the endosomal limiting membrane.
Eden, ER, Futter, CE
openaire   +3 more sources

Acid-labile chemical bonds-based nanoparticles for endosome escape and intracellular delivery

Biomedical Technology, 2023
In the last years there has been a booming in the development of biological pharmaceuticals, and various nanoparticle delivery systems have been developed to overcome biological barriers to maximize the therapeutic potentials. Especially, when these drug-
Ruoyu Cheng, Shiqi Wang, Hélder A. Santos   +2 more
doaj   +1 more source

Elucidating the Impact of Payload Conjugation on the Cell-Penetrating Efficiency of the Endosomal Escape Peptide dfTAT: Implications for Future Designs for CPP-Based Delivery Systems. [PDF]

Bioconjug Chem, 2023
Cell-penetrating peptides (CPPs) are promising tools for intracellular delivery of various biological payloads. However, the impact of payload conjugation on the cell-penetrating activity of CPPs remains poorly understood.
Diaz J, Pietsch M, Davila M, Jaimes G, Hudson A, Pellois JP.   +5 more
europepmc   +2 more sources

Acid-Labile Traceless Click Linker for Protein Transduction [PDF]

, 2012
Intracellular delivery of active proteins presents an interesting approach in research and therapy. We created a protein transduction shuttle based on a new traceless click linker that combines the advantages of click reactions with implementation of ...
Bachelder E. M., Dohmen C., Engin K., Ernst Wagner, Frohlich T., Kevin Maier, Lee Y., Meyer M., Meyer M., Meyer M., Miyata K., Murphy R. F., Murthy N., Nieto M. A., Rozema D. B., Rozema D. B., Saxon E., Schaffert D., Vallee M. R., Wagner E., Wagner E., Yu H.   +21 more
core   +1 more source

Exploring the HYDRAtion method for loading siRNA on liposomes : the interplay between stability and biological activity in human undiluted ascites fluid [PDF]

, 2016
Delivery of small interfering RNA (siRNA) is recently gaining tremendous attention for the treatment of ovarian cancer. The present study investigated the potential of different liposomal formulations composed of (2,3-dioleoyloxy-propyl)trimethylammonium
Braeckmans, Kevin, Ceelen, Wim, Dakwar, George, De Smedt, Stefaan, Remaut, Katrien   +4 more
core   +2 more sources

Selective targeting of chemically modified miR-34a to prostate cancer using a small molecule ligand and an endosomal escape agent. [PDF]

Mol Ther Nucleic Acids
Use of tumor-suppressive microRNAs (miRNAs) as anti-cancer agents is hindered by the lack of effective delivery vehicles, entrapment of the miRNA within endocytic compartments, and rapid degradation of miRNA by nucleases.
Abdelaal AM, Sohal IS, Iyer SG, Sudarshan K, Orellana EA, Ozcan KE, Dos Santos AP, Low PS, Kasinski AL.   +8 more
europepmc   +2 more sources

A display of pH-sensitive fusogenic GALA peptide facilitates endosomal escape from a Bio-nanocapsule via an endocytic uptake pathway [PDF]

, 2014
BACKGROUND: An affibody-displaying bio-nanocapsule (Z(HER2)-BNC) with a hepatocyte specificity derived from hepatitis B virus (HBV) was converted into an affibody, Z(HER2), that recognizes HER2 receptors.
Akihiko Kondo, Chiaki Ogino, Jun Ishii, Koichi Takeda, Ryosuke Ezawa, Yuya Nishimura   +5 more
core   +1 more source

Engineering lipid nanoparticles with improved endosomal escape for cytoplasmic delivery of RNA drugs [PDF]

Biofunctional Materials
RNA therapy, with its capabilities in regulating physiological processes directly by affecting the central dogma, holds great potential in the prevention and treatment of various diseases.
Ziqing Yan, Guangchao Qing, Xingjie Liang   +2 more
doaj   +1 more source

Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA [PDF]

, 2019
Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by various extra-
De Backer, Lynn, De Smedt, Stefaan, Echaide, Mercedes, Guagliardo, Roberta, Merckx, Pieterjan, Pérez-Gil, Jesus, Raemdonck, Koen, Zamborlin, Agata   +7 more
core   +1 more source

Solid-phase-assisted synthesis of targeting peptide-PEG-oligo(ethane amino)amides for receptor-mediated gene delivery. [PDF]

, 2012
In the forthcoming era of cancer gene therapy, efforts will be devoted to the development of new efficient and non-toxic gene delivery vectors. In this regard, the use of Fmoc/Boc-protected oligo(ethane amino)acids as building blocks for solid-phase ...
Akinc, Aumailley, Behr, Blessing, Boussif, Breunig, Carlos Mas-Moruno, Chollet, Christian Dohmen, Christina Troiber, Cotten, Cox, David Schaffert, Davis, Davis, Dechantsreiter, Desgrosellier, Drake, Edinger, Ellman, Erbacher, Ernest Giralt, Ernst Wagner, Felding-Habermann, Felgner, Fella, Grandinetti, Harbottle, Hartmann, Hartmann, Haubner, Horst Kessler, Irene Martin, J., Kantlehner, Kichler, Kim, Kursa, Li, Lin, Luthman, Madder, Mas-Moruno, McKenzie, Meritxell Teixidó, Merkel, Meyer, Meyer, Michael Günther, Moghimi, Mosca, Nie, Oba, Oupicky, Pack, Petra Kos, Pfaff, Plank, Reis, Ruoslahti, Russ, Russ, Schaffert, Schaffert, Schaffert, Schiffelers, Sonawane, Trubetskoy, Ulrich Lächelt, Varkouhi, Wagner, Wagner, Wagner, Wagner, Walker, Wu, Xia, Xu, Zintchenko   +78 more
core   +3 more sources