Results 41 to 50 of about 399,723 (294)
Novel endosomolytic compounds enable highly potent delivery of antisense oligonucleotides
Communications Biology, 2022 Two new endosomolytic small compounds increase delivery of splice-switching oligonucleotides by interfering with their trafficking to the LAMP1-positive endosomal compartments, inducing endosomal membrane rupture and concurrent oligonucleotide escape ...
Jeremy P. Bost +20 more
doaj +1 more source
mBio, 2023 Rapid phagosomal escape mediated by listeriolysin O (LLO) is a prerequisite for Listeria monocytogenes intracellular replication and pathogenesis. Escape takes place within minutes after internalization from vacuoles that are negative to the early ...
Robert J. Cain +3 more
doaj +1 more source
Design rules for efficient endosomal escape
, 2023 Abstract The inefficient translocation of proteins across biological membranes limits their application as therapeutic compounds and research tools. In most cases, translocation involves two steps: uptake into the endocytic pathway and endosomal escape.
Madeline Zoltek +5 more
openaire +2 more sources
Probing Endosomal Escape Using pHlexi Nanoparticles [PDF]
Macromolecular Bioscience, 2016 The effective escape of nanocarriers from endosomal compartments of the cell remains a major hurdle in nanomedicine. The endosomal escape of pH‐responsive, self‐assembled, dual component particles based on poly[2‐(diethylamino)ethyl methacrylate)(PDEAEMA) and poly(ethylene glycol)‐b‐poly[2‐(diethylamino)ethyl methacrylate) (PEG‐b‐PDEAEMA) has been ...
Kongkatigumjorn, N +6 more
openaire +3 more sources
Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles
Bioengineering & Translational Medicine, 2021 Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nano‐delivery system for therapeutic nucleic acids. The great effort put in the development of ionizable lipids with increased in vivo potency brought LNPs from the laboratory benches ...
Michele Schlich +6 more
doaj +1 more source
Poly(2-propylacrylic acid)/poly(lactic-co-glycolic acid) blend microparticles as a targeted antigen delivery system to direct either CD4+ or CD8+ T cell activation. [PDF]
, 2017 Poly(lactic-co-glycolic acid) (PLGA) based microparticles (MPs) are widely investigated for their ability to load a range of molecules with high efficiency, including antigenic proteins, and release them in a controlled manner.
Bracho-Sanchez, Evelyn +6 more
core +1 more source
Nanomaterials, 2021 The ability to predict the behaviour of polymeric nanomedicines can often be obfuscated by subtle modifications to the corona structure, such as incorporation of fluorophores or other entities.
Joshua D. Simpson +7 more
doaj +1 more source
In vivo delivery of transcription factors with multifunctional oligonucleotides. [PDF]
, 2015 Therapeutics based on transcription factors have the potential to revolutionize medicine but have had limited clinical success as a consequence of delivery problems. The delivery of transcription factors is challenging because it requires the development
Aran, Kiana +9 more
core +6 more sources
An Endosomal Escape Trojan Horse Platform to Improve Cytosolic Delivery of Nucleic Acids. [PDF]
ACS NanoEndocytosis is a major bottleneck toward cytosolic delivery of nucleic acids, as the vast majority of nucleic acid drugs remain trapped within endosomes.
Narum S +5 more
europepmc +2 more sources
The thermodynamics of endosomal escape and DNA release from lipoplexes [PDF]
Physical Chemistry Chemical Physics, 2016 In this work we identify and characterize the entropic driving forces governing the process of transfection by lipid–DNA complexes.
Avital, Yotam Y. +2 more
openaire +3 more sources