Results 131 to 140 of about 138,036 (346)

A phorbol ester-binding protein is required downstream of Rab5 in endosome fusion [PDF]

, 1998
Previous observations indicate that a zinc and phorbol ester binding factor is necessary for endosome fusion. To further characterize the role of this factor in the process, we used an in vitro endosome fusion assay supplemented with recombinant Rab5 ...
Mayorga, Luis S, Luis S Mayorga, Colombo, Marı́a I, Arenas, Graciela N, Marı́a I Colombo, Barbieri, M.Alejandro, Philip D Stahl, M.Alejandro Barbieri, Aballay, Alejandro, Stahl, Philip D, Alejandro Aballay, Graciela N Arenas   +11 more
core   +1 more source

The late endosome and its lipid BMP act as gateways for the efficient cytosolic access of the delivery agent dfTAT and its macromolecular cargos

Cell Chemical Biology, 2016
Endosomal entrapment is a severely limiting bottleneck in the delivery of biologics into cells. The compound dfTAT was recently found to circumvent this problem by mediating endosomal leakage efficiently and without toxicity.
Alfredo Erazo-Oliveras, Kristina Najjar, Dat P. Truong, Ting-Yi Wang, Dakota J. Brock, A. Prater, J. Pellois   +6 more
semanticscholar   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

ESCRT proteins, endosome organization and mitogenic receptor down-regulation [PDF]

, 2009
Mitogenic tyrosine kinase receptors such as the EGFR (epidermal growth factor receptor) are endocytosed once they are activated at the cell surface.
Woodman, Philip; id_orcid
core   +1 more source

EHD3-Dependent Endosome Pathway Regulates Cardiac Membrane Excitability and Physiology

Circulation Research, 2014
Rationale: Cardiac function is dependent on the coordinate activities of membrane ion channels, transporters, pumps, and hormone receptors to tune the membrane electrochemical gradient dynamically in response to acute and chronic stress.
J. Curran, Michael A. Makara, Sean C. Little, Hassan Musa, Bin Liu, Xiangqiong Wu, I. Polina, J. Alecusan, Patrick J. Wright, Jingdong Li, G. Billman, Penelope A. Boyden, S. Gyorke, Hamid Band, T. Hund, Peter J. Mohler   +15 more
semanticscholar   +1 more source

Rapid Endosomal Recycling

, 2018
Peripheral membrane proteins are endocytosed by constitutive processes of membrane invaginations, followed by internalization driven by diverse endocytic machinery available at the cell surface. It is believed that after endocytic uptake, cargo proteins proceed either through the endosomal recycling circuit of the cell or travel toward late endosomes ...
Mahmutefendić, Hana, Blagojević Zagorac, Gordana, Maćešić, Senka, Lučin, Pero   +3 more
openaire   +3 more sources

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

Phospholipid, cholesterol, polypeptide and glycoprotein composition of hepatic endosome subfractions [PDF]

, 1985
The composition of hepatic endosome subfractions was compared directly with that of plasma membranes and Golgi-apparatus fractions. The neutral lipid and phospholipid composition of two endosome subfractions separated on Nycodenz gradients from a parent ...
Evans, William Howard, Hardison, W. G.
core  

Mathematical model for low density lipoprotein (LDL) endocytosis by hepatocytes [PDF]

, 2008
Individuals with elevated levels of plasma low density lipoprotein (LDL) cholesterol (LDL-C) are considered to be at risk of developing coronary heart disease.
B. O’Malley, J. A. D. Wattis, Panovska, J., Byrne, H.M., Jackson, K.G., H. Blackburn, Wattis, JA, H. M. Byrne, L. Pickersgill, O'Malley, B, Panovska, J, Wattis, J.A.D., Pickersgill, L, Pickersgill, L., Blackburn, H, Byrne, HM, Byrne, Helen, K. G. Jackson, Wattis, JAD, O'Malley, B., Blackburn, H., Jackson, KG, J. Panovska   +22 more
core   +1 more source

ALG-2-interacting Tubby-like protein superfamily member PLSCR3 is secreted by an exosomal pathway and taken up by recipient cultured cells

Bioscience Reports, 2013
PLSCRs (phospholipid scramblases) are palmitoylated membrane-associating proteins. Regardless of the given names, their physiological functions are not clear and thought to be unrelated to phospholipid scrambling activities observed in vitro ...
Tatsutoshi Inuzuka, Akira Inokawa, Cen Chen, Kumiko Kizu, Hiroshi Narita, Hideki Shibata, Masatoshi Maki   +6 more
doaj   +1 more source