Results 111 to 120 of about 138,036 (346)
Investigation of Endosome and Lysosome Biology by Ultra pH-Sensitive Nanoprobes
Advanced Drug Delivery Reviews, 2016 &NA; Endosomes and lysosomes play a critical role in various aspects of cell physiology such as nutrient sensing, receptor recycling, protein/lipid catabolism, and cell death.
Chensu Wang +5 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.The nanostructure, size, and function of mRNA‐loaded lipid nanoparticles are evaluated before drying, within polymer microneedles, and after rehydration. The results reveal the polymer and LNP loadings required to recover nanostructure and preserve the delivery performance in dry‐state formulations.
Brendan P. Dyett +19 more
wiley +1 more source
A cycling cis-Golgi protein mediates endosome-to-Golgi traffic. [PDF]
, 2018 Toxins can invade cells by using a direct endosome-to-Golgi endocytic pathway that bypasses late endosomes/prelysosomes. This is also a route used by endogenous proteins, including GPP130, which is an integral membrane protein retrieved via the bypass ...
Adam Linstedt (3889318) +1 more
core +1 more source
Post-Golgi Trafficking and Transport of Cell Wall Components
Frontiers in Plant Science, 2018 The cell wall, a complex macromolecular composite structure surrounding and protecting plant cells, is essential for development, signal transduction, and disease resistance. This structure is also integral to cell expansion, as its tensile resistance is
Rosalie Sinclair +2 more
doaj +1 more source
Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery
Advanced Functional Materials, EarlyView.A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon +5 more
wiley +1 more source
Visualization of Ras-PI3K interaction in the endosome using BiFC [PDF]
, 2009 Recent studies indicate the importance of spatiotemporal regulation in the diversity and specificity of intracellular signaling. Here, we show that Ras-PI3K signaling plays an important role in the local regulation of phosphatidylinositol metabolism in ...
Ohba, Yusuke +4 more
core +1 more source
Mechanisms by which SNX-BAR subfamily controls the fate of SNXs’ cargo
Frontiers in PhysiologyThe SNX-BAR subfamily is a component of the sorting nexins (SNXs) superfamily. Distinct from other SNXs, which feature a PX domain for phosphoinositide binding, the SNX-BAR subfamily includes a BAR domain that induces membrane curvature.
Yaolin Long +6 more
doaj +1 more source
ATG12-ATG3 Interacts with Alix to Promote Basal Autophagic Flux and Late Endosome Function
Nature Cell Biology, 2015 The ubiquitin-like molecule ATG12 is required for the early steps of autophagy. Recently, we identified ATG3, the E2-like enzyme required for LC3 lipidation during autophagy, as an ATG12 conjugation target.
Lyndsay M. Murrow +2 more
semanticscholar +1 more source
Advanced Materials, EarlyView.Bioorthogonal chemistry was applied to intracellularly photoactivate Doxorubicin (Dox) using gold nanostars (AuNSt) and near‐infrared (NIR) light. Two prodrugs were used: one photoactivatable, masked with 2‐nitrobenzyl carbamate (proDox1) and another photolabile, masked with 2‐nitrobenzyl diol (proDox2), which was attached to the AuNSt surface.
Juan José Esteve‐Moreno +15 more
wiley +1 more source
Negative regulation of phosphatidylinositol 3-phosphate levels in early-to-late endosome conversion
Journal of Cell Biology, 2016 C. elegans SORF-1 and SORF-2 and their mammalian homologs WDR91 and WDR81 maintain appropriate PtdIns3P levels in early-to-late endosome conversion by forming a complex with the Beclin1 subunit of the PI3K complex.
Kai Liu +12 more
semanticscholar +1 more source