Results 141 to 150 of about 138,036 (346)
Advanced Science, EarlyView.This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong +6 more
wiley +1 more source
The kinetics of endosome processing [PDF]
, 1995 The present thesis looks at the behaviour of internalised cell surface-derived membrane marker in comparison with the behaviour of endocytosed HRP (horse-radish peroxidase) as a fluid-phase contents marker.
Legalatladi, Seetsela
core +1 more source
RhoD, Src, and hDia2C in Endosome Motility [PDF]
, 2003 The positioning of early endosomes is a dynamic process requiring coordinated activity of both actin and microtubules with their associated motors. A recent report from Marino Zerial and colleagues examining RhoD identifies mDia2C, a novel splice variant
Randazzo, Paul A
core +1 more source
Molecular Biology of the Cell, 2016 The endocytic recycling compartment maintains segregation of cargo after sorting in peripheral endosomes, and cargo is recycled by distinct pathways to the plasma membrane.
Shuwei Xie +5 more
semanticscholar +1 more source
A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates
Advanced Science, EarlyView.Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao +7 more
wiley +1 more source
HookA is a novel dynein-early endosome linker critical for cargo movement in vivo [PDF]
, 2014 18 p.-9 fig.Cytoplasmic dynein transports membranous cargoes along microtubules, but the mechanism of dynein-cargo interaction is unclear. From a genetic screen, we identified a homologue of human Hook proteins, HookA, as a factor required for dynein ...
Jun Zhang +9 more
core +1 more source
ER contact sites define the position and timing of endosome fission
Cell, 2014 Summary Endocytic cargo and Rab GTPases are segregated to distinct domains of an endosome. These domains maintain their identity until they undergo fission to traffic cargo.
Ashley A. Rowland +3 more
semanticscholar +1 more source
Oligopeptides/DNA Coacervate Droplets as Macromolecular Delivery Microcarriers
Advanced Science, EarlyView.Oligopeptide–DNA coacervates formed via liquid–liquid phase separation serve as programmable carriers for macromolecular cargos, entering cells through lipid raft–associated pathways and subsequently undergoing enzyme triggered intracellular disassembly driven by DNA degradation processes, thereby enabling efficient, controlled, and spatially defined ...
Linyi Zhang +5 more
wiley +1 more source
Cholesterol Level Regulates Endosome Motility via Rab Proteins [PDF]
, 2008 The role of cholesterol in the regulation of endosome motility was investigated by monitoring the intracellular trafficking of endocytosed folate receptors (FRs) labeled with fluorescent folate conjugates.
Chen, Hongtao +7 more
core +1 more source
Advanced Science, EarlyView.A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang +10 more
wiley +1 more source