Results 171 to 180 of about 144,544 (285)

NoxO1 promotes endosome formation and reduces intracellular vesicle processing. [PDF]

Redox Biol
Hebchen M, Herwig F, Schader T, Spaeth M, Müller N, Schröder K.   +5 more
europepmc   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Vesicle-coupled mRNA transport and translation govern intracellular organelle networking. [PDF]

EMBO Rep
Vázquez-Carrada M, Shanmugasundaram S, Smits SHJ, van Wijlick L, Feldbrügge M.   +4 more
europepmc   +1 more source

Molecular crosstalk via exosomes in lung cancer progression

Interdisciplinary Medicine, EarlyView.
“Molecular and theranostics roles of exosomes in Lung Cancer.” Abstract Exosomes play a critical role in lung cancer metastasis, facilitating tumor progression through intercellular communication between cancer cells and the tumor microenvironment. These nanosized extracellular vesicles carry bioactive molecules such as proteins, nucleic acids, and ...
Rajib Dhar, Vinoth Kumarasamy, Brian G. Oliver, Vetriselvan Subramaniyan   +3 more
wiley   +1 more source

Endosome maturation during ER stress relies on the ubiquitin-binding domain of histone deacetylase 6. [PDF]

Mol Biol Cell
Piscopo KM, Larson B, Christiansen AM, Perry JM, Hollien J.   +4 more
europepmc   +1 more source

Poly(2‐Oxazoline)‐Based Polyphotoacids: Synthesis, Solution Behavior, and Cellular Uptake of Multi‐Responsive Intracellular Transporters

Macromolecular Rapid Communications, EarlyView.
The ability of photoacids to increase their acidity in response to light irradiation (excited state proton transfer, ESPT) makes them attractive building blocks for the design of stimuli‐responsive copolymers. In this contribution, we present highly biocompatible polyphotoacids based on poly(2‐oxazoline)s bearing 1‐hydroxypyrene units. Low cytotoxicity,
Leonid I. Kaberov, Amod Godbole, Laura Klement, Sreevalsan Achikkulathu, Avinash Chettri, Benjamin Dietzek‐Ivanšić, Carsten Hoffmann, Felix H. Schacher   +7 more
wiley   +1 more source

Endosomal Escape of Lipid Nanoparticles: A Perspective on the Literature Data. [PDF]

ACS Nano
Pei D.
europepmc   +1 more source

Bioinspired, Guanidinium, and Indole Modified Poly(glycidyl ether)s as Highly Efficient Vectors for Polyplex‐Mediated Gene Delivery

Macromolecular Rapid Communications, EarlyView.
Guanidinium‐ and indole‐functionalized poly(glycidyl ether)s were developed as non‐viral gene delivery vectors with tunable hydrophilic–hydrophobic balance. All polymers formed stable DNA polyplexes, while moderate indole content yielded the highest transfection efficiency at low N/P ratios.
Markus Kötzsche, Andreas Dzierza, Lennert Sölter, Jan Egger, Kjell Cornelis, Andreas Stihl, Felix H. Schacher, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

Efficient cellular transformation via protein delivery through the protrusion-derived extracellular vesicles. [PDF]

Nat Commun
Fujioka T, Nishimura T, Kawana H, Hirosawa KM, Yamakawa R, Sapili H, Oono-Yakura K, Nakagawa R, Inoue T, Nureki O, Suzuki KGN, Suetsugu S.   +11 more
europepmc   +1 more source

Non‐Histone Lactylation: A New Frontier in Cerebral Ischemia‐Reperfusion Injury

Med Research, EarlyView.
ABSTRACT Reperfusion therapy is the mainstay of treatment for ischemic stroke (IS) but frequently exacerbates secondary injury. Following cerebral ischemia and hypoxia, lactate accumulates markedly. Traditionally regarded as a metabolic byproduct, lactate has gained new significance with the discovery of protein lactylation. In addition to experimental
Minghui Tang, Yuying Mo, Zhishan Ling, Yuting Zeng, Qi Zhang, Shuqi Zheng, Shuyang Wen, Yupeng Xiao, Siying Long, Tingting Yang, Qianru Li, Wenjie Shi, Guozhi Huang, Qing Zeng   +13 more
wiley   +1 more source