Results 181 to 190 of about 143,380 (285)

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Intracellular Localization of PD-L1 in Rab10-positive Open Tubular Endosome System of Cancer Cells. [PDF]

Acta Histochem Cytochem
Yamada R, Sakamoto R, Kawai K, Egami Y, Araki N.   +4 more
europepmc   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

A luminescent reporter assay to quantify SORL1 ectodomain shedding and retromer-dependent endosome recycling activity. [PDF]

J Biol Chem
Fazeli E, Jan A, Huber AK, Jensen AMG, Fazeli E, Klein J, Merchant K, Andersen OM.   +7 more
europepmc   +1 more source

Earliest endosomes [PDF]

Nature Reviews Molecular Cell Biology, 2009
openaire   +1 more source

Molecular dynamics simulations of oleuropein diffusion in chitosan‐based nanoparticles

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND This study explores the diffusion mechanisms of oleuropein (OLE), a promising polyphenolic compound, within chitosan‐based nanoparticles using molecular dynamics simulations. Chitosan nanoparticles serve as drug delivery carriers, leveraging biocompatibility and tunable release properties influenced by environmental factors such as ...
Bernardino Tirri, Andrea Lorenzoni, Francesco Mercuri, Pietro Calandra   +3 more
wiley   +1 more source

Poration by alpha-toxin and streptolysin O [PDF]

, 1989
Ahnert-Hilger, Gudrun, Föhr, Karl Josef, Gratzl, Manfred, Mach, Wolfgang   +3 more
core   +1 more source

miR‐9 Restricts Insulin Secretion by Targeting Rab34, Which Mediates Lysosomal Degradation of Proinsulin

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Insulin secretion is a complex, vesicular transport process. Rab34 is a key regulator of intracellular vesicle transport; however, its role in insulin secretion has not yet been reported. miRNA‐9 is vital for the development and progression of the diagnosis and treatment of type 2 diabetes. This study aimed to investigate whether miR‐9 targets
Zhen‐Zhen Guo, Ao‐Ying Li, Ting‐Ting Xiang, Zu‐Hao Zhang, Ao Deng, Yang Han   +5 more
wiley   +1 more source

Poly(2‐Oxazoline)‐Based Polyphotoacids: Synthesis, Solution Behavior, and Cellular Uptake of Multi‐Responsive Intracellular Transporters

Macromolecular Rapid Communications, EarlyView.
The ability of photoacids to increase their acidity in response to light irradiation (excited state proton transfer, ESPT) makes them attractive building blocks for the design of stimuli‐responsive copolymers. In this contribution, we present highly biocompatible polyphotoacids based on poly(2‐oxazoline)s bearing 1‐hydroxypyrene units. Low cytotoxicity,
Leonid I. Kaberov, Amod Godbole, Laura Klement, Sreevalsan Achikkulathu, Avinash Chettri, Benjamin Dietzek‐Ivanšić, Carsten Hoffmann, Felix H. Schacher   +7 more
wiley   +1 more source

When two worlds collide: actin dynamics on endomembranes regulates membrane trafficking. [PDF]

Curr Opin Cell Biol
Marchan MF, Bear JE.
europepmc   +1 more source