Results 211 to 220 of about 143,380 (285)

Efficient cellular transformation via protein delivery through the protrusion-derived extracellular vesicles. [PDF]

Nat Commun
Fujioka T, Nishimura T, Kawana H, Hirosawa KM, Yamakawa R, Sapili H, Oono-Yakura K, Nakagawa R, Inoue T, Nureki O, Suzuki KGN, Suetsugu S.   +11 more
europepmc   +1 more source

Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells [PDF]

, 2008
Delputte, Peter, Misinzo, Gerald, Nauwynck, Hans   +2 more
core  

Gold@MnFe‐Prussian Blue Analog Yolk@Shell Nanoparticles for Light‐Triggered and pH‐Sensitive Drug Release

Small, EarlyView.
ABSTRACT Yolk@shell nanostructures have emerged as promising platforms for biomedical applications due to their unique architecture, which combines the high surface area and loading capacity of hollow nanoparticles with the structural stability and functional versatility of core@shell systems. In this work, we report the synthesis of multifunctional Au@
Shoaib Azeem, Javier Alda‐Gómez, Roger Sanchis‐Gual, Marc Coronado‐Puchau, Eugenio Coronado Miralles   +4 more
wiley   +1 more source

Cholesterol Deficiency Directs Autophagy-Dependent Secretion of Extracellular Vesicles. [PDF]

J Extracell Vesicles
Yaeger JDW, Sengupta S, Walz AL, Morita M, Morgan TK, Vermeer PD, Francis KR.   +6 more
europepmc   +1 more source

Photo‐induced proton release of spiropyran‐derived nanomaterials for mRNA delivery in hard‐to‐transfect cells

Smart Molecules, EarlyView.
Light‐induced proton release from spiropyran can disrupt the stability of both nanoparticles and endosomal membranes, thereby promoting endosomal escape and ultimately enhancing transfection performance. Abstract Messenger RNA (mRNA) therapy has been explored as a treatment for various genetic disorders. Significant progress has been made in developing
Caiwei Lu, Zhiwei Zhou, Leilei Li, Zhu Yu, Feiyu Chen, Yi Xiao, Xinfu Zhang   +6 more
wiley   +1 more source

Nanobody–chlorin e6 conjugate for Nectin‐4‐mediated tumor targeting and enhanced photodynamic therapy

VIEW, EarlyView.
Nectin‐4 is frequently overexpressed in solid tumors, yet many PDT photosensitizers show poor water solubility and nonspecific uptake. A Nectin‐4‐targeted nanobody–chlorin e6 conjugate (NPC) improves aqueous solubility and selectively accumulates in Nectin‐4‐positive tumor cells.
Haodian Wan, Tao Ye, Yawei Bi, Jiayu Zhang, Wei Wu, Aochi Liu, Li Sun, Jie Lin, Ningli Chai, Manjie Zhang, Jian Ma   +10 more
wiley   +1 more source

PCM1 coordinates centrosome asymmetry with polarized endosome dynamics to regulate daughter cell fate. [PDF]

Nat Commun
Zhao X, Mouilleau V, Wang Y, Solak AC, Garcia JQ, Chen X, Shi X, Wilkinson CJ, Royer LA, Dong Z, Guo S.   +10 more
europepmc   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

LPC-engineered liposomes activate transcytosis for paclitaxel brain delivery and potentiation of TTFields/TMZ via TALECT regimen in glioblastoma. [PDF]

Theranostics
Zhan Q, Yi K, Yang S, Hong B, Su D, Zhao J, Wang Q, Cui X, Huang Y, Ding Y, Cheng C, Ju J, Kang C.   +12 more
europepmc   +1 more source

miRNA Profiling of Cholesteatoma‐Derived Exosomes Reveals Exosomal miR‐223‐3p and miR‐142‐5p as Potential Biomarkers for Acquired Middle Ear Cholesteatoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives Acquired cholesteatoma is an abnormal and invasive growth of keratinized squamous epithelial cells in the middle ear. The study aims to explore the role of exosomal miRNAs in the pathogenesis of acquired cholesteatoma and their potential in clinical application.
Qi Tang, Meng‐Yao Xie, Shu Wang, Zhi‐Yuan Wu, Zhi‐Jin Han, Chen Li, Shu‐Yi Wang, Yuan Cao, Yu‐Run Chen, Bin Wang, Ying‐Ying Shang, Xiao‐Wu Huang, Hua Yang   +12 more
wiley   +1 more source