Results 241 to 250 of about 143,380 (285)

PEGylated Chitosan Nanoparticles: Engineering Multifunctional Platforms for Targeted Cervical and Lung Cancer Treatment

Cancer Science, EarlyView.
Graphical representation of formation of self‐assembled PEGylated Chitosan Nanoparticles and their mechanism in tumor localization. ABSTRACT Polymer‐based nanocarriers have emerged as transformative platforms in cancer nanomedicine, enabling controlled and site‐specific delivery of therapeutic agents.
Prashant Kesharwani, Nazim Nasir, Shadma Wahab, Garima Gupta, Khang Wen Goh, Amirhossein Sahebkar   +5 more
wiley   +1 more source

CNTF specifically slows down the axonal transport of signalling endosomes

Rhymes ER, Sleigh JN, Schiavo G, Tosolini AP.   +3 more
europepmc   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Rare variants in <i>NRSN2</i> cause non-syndromic orofacial cleft through dysregulation of TGF-β signaling. [PDF]

Genes Dis
Zheng X, Liang X, Wu X, He Q, Yin C, Jiao Y, Wang Y, Hou Y, Ding Y, Zhao H.   +9 more
europepmc   +1 more source

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Effect of pH on small-molecule inhibitor binding to influenza virus hemagglutinin. [PDF]

J Biol Chem
Anirudhan V, Gaisina I, Shimon A, Lee H, Alqarni S, Manicassamy B, Moore TW, Xu K, Caffrey M, Rong L.   +9 more
europepmc   +1 more source

Cullin 3 substrate-adaptor protein 1 (MtCSP1) modulates nodulation through interaction with the GTPase ARFA1. [PDF]

Sci Rep
Rípodas C, Cretton M, Eylenstein A, Rivero C, Zanetti ME, Blanco F.   +5 more
europepmc   +1 more source

Beyond the membrane: rethinking EGFR signaling in physiology and cancer. [PDF]

Cell Mol Life Sci
Jendrisek G, Mesa D, Conte A, Malabarba MG, Sigismund S.   +4 more
europepmc   +1 more source

Correction: Intracellular virion traffic to the endosome driven by cell type specific sialic acid receptors determines parvovirus tropism. [PDF]

Front Microbiol
Calvo-López T, Grueso E, Sánchez-Martínez C, Almendral JM.   +3 more
europepmc   +1 more source