Results 241 to 250 of about 144,544 (285)

GPNMB, LRRK2, and lysosome exocytosis in Parkinson's. [PDF]

Sci Adv
Pfeffer SR.
europepmc   +1 more source

Clinical trajectories and medication response in TBC1D24‐related epilepsies

Epilepsia, EarlyView.
Abstract Objective Biallelic variants in TBC1D24 represent a rare cause of epilepsy and neurodevelopmental disorders, including severe developmental and epileptic encephalopathies. Here, we present the first attempt to delineate the longitudinal disease histories and effectiveness of antiseizure medications (ASMs) in TBC1D24‐related disorders.
Ealing Mondragon, Jan H. Magielski, Bintou Bane, JoeyLynn Nolan, Sarah M. Ruggiero, Dallas Armstrong, Susan Arnold, Deepa Sirsi, Ingo Helbig, Jillian L. McKee   +9 more
wiley   +1 more source

Editor's Note to: Barley endosomal MONENSIN SENSITIVITY1 is a target of the powdery mildew effector CSEP0162 and plays a role in plant immunity. [PDF]

J Exp Bot
europepmc   +1 more source

SUMOylation-dependent degradation of nucleocapsid is responsible for <i>Pestivirus</i> uncoating. [PDF]

J Virol
Zou L-K, Bai J-s, Sun R-c, Yang H-f, Wan M-y, Zhao B-q, Sun B-t, Chen J-x, Chen J, Cheng Y, Zhou B.   +10 more
europepmc   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Probing spatiotemporally organized GPCR signaling using genetically encoded molecular tools. [PDF]

Exp Mol Med
Kwon Y, Mehta S, Zhang J.
europepmc   +1 more source

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

The FEBS Journal, EarlyView.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza, Romain Vergé, Raoul Mazars, Laurence Berry, Céline Cougoule   +4 more
wiley   +1 more source

Multispectral live-cell imaging with uncompromised spatiotemporal resolution. [PDF]

Nat Photonics
Kumar A, McNally KE, Zhang Y, Haslett-Saunders A, Wang X, Guillem-Marti J, Lee D, Huang B, Stallinga S, Kay RR, Baker D, Derivery E, Manton JD.   +12 more
europepmc   +1 more source

Adaptor protein complex 1 gamma 1 subunit is an important host factor involved in both Zika virus and dengue virus infections. [PDF]

Virol Sin
Yang J, Huang C, Feng Y, He J, Liu Y, Zhang P, Liu C.   +6 more
europepmc   +1 more source

Differential roles for CLA-1L and UNC-10 in endosomal maturation and peptide release at <i>C. elegans</i> synapses impacting lifespan. [PDF]

Front Mol Biosci
Krout M, Miciulis E, Lai PQ, Richmond JE.   +3 more
europepmc   +1 more source