Results 211 to 220 of about 187,332 (400)

Nanoparticle‐Based Tolerogenic Vaccines: Next‐Generation Strategies for Autoimmune and Allergic Disease Therapies

Angewandte Chemie, EarlyView.
Nanoparticle‐based tolerogenic vaccines harness controlled antigen delivery and immunomodulation to establish tolerance in autoimmunity and allergy. This review outlines how nanoparticle design (size, shape, composition, administration route) influences biodistribution and immune‐cell targeting.
Benjamin E. Nachod, Ajay S. Thatte, Rohan Palanki, Michael J. Mitchell   +3 more
wiley   +2 more sources

Fluorescent biosensors illuminate calcium levels within defined beta-cell endosome subpopulations

, 2015
Tobias Albrecht, Yongxin Zhao, Trang Nguyen, Robert E. Campbell, James D. Johnson   +4 more
openalex   +1 more source

Versatile DNA Hydrogel‐Mediated Delivery of Ginsenoside‐Encapsulated Small Extracellular Vesicles to Boost Diabetic Wound Repair

Advanced Science, EarlyView.
This study presents a DNA hydrogel‐mediated delivery system, in which ginsenoside (GS) molecules are incorporated into small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSCs) and the formed complexes are then anchored in DNA hydrogels via aptamer‐CD63 affinity as “GS/sEV@DNAgels”, to improve diabetic wound repair.
Jianming Xing, Shuangyang Li, Yuning Wang, Xushuang Jia, Ruiting Lin, Xintong Liu, Dongxu Wang, Ning Cui, Peng Ji, Jiaqi Chen, Shengnian Wang, Guangzhe Li, Ye Teng, Da Liu, Ye Jin   +14 more
wiley   +1 more source

Correction: Corrigendum: Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB [PDF]

, 2016
Tong Wang, Sally Martin, Tam Nguyen, Callista B. Harper, Rachel S. Gormal, Ramón Martínez‐Mármol, Shanker Karunanithi, Elizabeth J. Coulson, Nick R. Glass, Justin J. Cooper‐White, Bruno van Swinderen, Frédéric A. Meunier   +11 more
openalex   +1 more source

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

Nature Biotechnology, 2015
Anders Wittrup, Angela Ai, Xing Liu, P. Hamar, R. Trifonova, K. Charissé, M. Manoharan, T. Kirchhausen, J. Lieberman   +8 more
semanticscholar   +1 more source

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

Balancing Cationic and Hydrophobic Content of PEGylated siRNA Polyplexes Enhances Endosome Escape, Stability, Blood Circulation Time, and Bioactivity in Vivo

, 2013
Christopher E. Nelson, James R. Kintzing, Ann Hanna, Joshua M. Shannon, Mukesh Kumar Gupta, Craig L. Duvall   +5 more
openalex   +1 more source

Supplementary Fig 6 from Neuropilin-2 Regulates Endosome Maturation and EGFR Trafficking to Support Cancer Cell Pathobiology

, 2023
Samikshan Dutta, Sohini Roy, Navatha S. Polavaram, Marissa J. Stanton, Heyu Zhang, Tanvi Bhola, Pia Hönscheid, Terrence M. Donohue, Hamid Band, Surinder K. Batra, Michael H. Muders, Kaustubh Datta   +11 more
openalex   +1 more source

Infantile‐Onset Ascending Hereditary Spastic Paraplegia due to a Homozygous ALS2 Exons 24–25 Deletion: Expanding the Genotypic Spectrum

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We describe a novel homozygous intragenic deletion in the ALS2 gene in an 8‐year‐old boy with Infantile‐onset Ascending Hereditary Spastic Paraplegia (IAHSP) and oculomotor apraxia, thereby contributing to the expanding genetic landscape of ALS2‐related disorders.
Vito Luigi Colona, Maria Gnazzo, Silvia Genovese, Gessica Vasco, Lorena Travaglini, Maurizio Sabbadini, Marina Macchiaiolo, Francesco Nicita, Jacopo Sartorelli, Carmelo Piscopo, Enrico Castelli, Enrico Bertini, Andrea Bartuli, Antonio Novelli, Gessica Della Bella, Davide Vecchio   +15 more
wiley   +1 more source

Truncated tau disrupts autophagy and endolysosomal systems

Autophagy Reports
Saskia J. Pollack, Diane P. Hanger, Wendy Noble, Maria Jimenez-Sanchez   +3 more
doaj   +1 more source