Results 251 to 260 of about 155,580 (293)

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Ionic Mechanisms of Two-Pore Channel Regulation of Vesicle Trafficking. [PDF]

Cells
Zhang H, Zhu MX.
europepmc   +1 more source

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Subcellular Cartography of the Phosphoinositide Multiverse. [PDF]

Biochim Biophys Acta Mol Cell Biol Lipids
Ricci MMC, Weckerly CC, Hammond GRV.
europepmc   +1 more source

Variability in intracellular localization of D‐amino acid oxidase in choroid plexus epithelial cells

The FEBS Journal, EarlyView.
D‐amino acid oxidase (DAO) in choroid plexus epithelial cells (CPECs) shows vesicle‐like localization by histological and super‐resolution analyses. DAO colocalizes with peroxisomal, Golgi, endosomal, lysosomal, autophagosomal, and exosomal markers, indicating diverse subcellular distribution. This suggests DAO is transported within CPECs to metabolize
Koji Ono, Yuji Shishido, Toshiyuki Yamagishi, Kiyoshi Fukui   +3 more
wiley   +1 more source

Beyond the membrane: Internalization and compartmentalization of insulin‑like growth factor 1 receptor signaling in cancer pathogenesis and treatment (Review). [PDF]

Int J Oncol
Zhang T, Li L, Du C.
europepmc   +1 more source

Mitophagy and Bip-PERK-eIF2α-ATF4 Axis-Mediated ER Stress Mediate Miriplatin-Loaded Liposome's Anti-Colorectal Cancer Action. [PDF]

Cell Prolif
Zhao C, Qiu Y, Wang X, Wang M, Liu L, Zhao X, Gao Z, Shao R, Xia G, Zhao W.   +9 more
europepmc   +1 more source

Alterations in bone malformation in the absence of the endosomal SNAREs Vti1a and Vti1b. [PDF]

PLoS One
Schmücker S, Schöning S, Wiegand C, Höfling SM, Bollmann C, Koliwer J, Fischer von Mollard G.   +6 more
europepmc   +1 more source

Functional miRNA Transfer in Models of Serous Ovarian Carcinoma. [PDF]

Cancers (Basel)
Muralidhar GG, Main HG, Xie J, Suarez JS, Barbolina MV.   +4 more
europepmc   +1 more source

Therapeutic and preventive strategies based on the maladaptive plasticity hypothesis for Alzheimer's disease. [PDF]

Front Aging Neurosci
Kawabata S.
europepmc   +1 more source